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D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
12983
World Ranking
7577
National Ranking
3442

Overview

Kathleen M. Trybus is affiliated with the University of Vermont in the United States and has a research focus spanning biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Their work covers a range of subfields including cell biology, molecular biology, cardiology and cardiovascular medicine, epidemiology, as well as public health, environmental and occupational health.

Their research topics encompass diverse areas, with notable emphasis on microtubule and mitosis dynamics, cardiomyopathy and myosin studies, Trypanosoma species research and implications, and mechanisms of cellular transport and secretion. Additional topics include cellular mechanics and interactions, malaria research and control, and investigations into nuclear structure and function.

Kathleen M. Trybus has published in various academic venues, with frequent contributions to:

  • Biophysical Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • Nature Communications
  • eLife

Selected recent papers illustrating their ongoing research interests include:

  • "The actomyosin interface contains an evolutionary conserved core and an ancillary interface involved in specificity," 2021, Nature Communications
  • "Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets," 2020, eLife
  • "Coil-to-α-helix transition at the Nup358-BicD2 interface activates BicD2 for dynein recruitment," 2022, eLife
  • "Coiled-coil registry shifts in the F684I mutant of Bicaudal D result in cargo-independent activation of dynein motility," 2020, Traffic
  • "Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription," 2020, Cell Reports

Frequent co-authors in their collaborative research include Patricia M. Fagnant, M. Yusuf Ali, Sozanne R. Solmaz, Julien Robert-Paganin, and Daniel Auguin, with multiple joint publications reflecting recurring partnerships in the scientific investigations.

Best Publications

  • Crystal structure of a vertebrate smooth muscle myosin motor domain and its complex with the essential light chain: visualization of the pre-power stroke state.

    Roberto Dominguez;Yelena Freyzon;Kathleen M Trybus;Carolyn Cohen

  • A bent monomeric conformation of myosin from smooth muscle.

    Kathleen M. Trybus;Ted W. Huiatt;Susan Lowey

  • Three-dimensional image reconstruction of dephosphorylated smooth muscle heavy meromyosin reveals asymmetry in the interaction between myosin heads and placement of subfragment 2.

    Thomas Wendt;Dianne Taylor;Kathleen M. Trybus;Kenneth Taylor

  • Smooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro.

    David M. Warshaw;Janet M. Desrosiers;Steven S. Work;Kathleen M. Trybus

  • Myosin V: regulation by calcium, calmodulin, and the tail domain

    Dimitry N. Krementsov;Elena B. Krementsova;Kathleen M. Trybus

  • Three-dimensional structure of the myosin V inhibited state by cryoelectron tomography.

    Jun Liu;Dianne W. Taylor;Elena B. Krementsova;Kathleen M. Trybus

  • Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections

    Dianna M Milewicz;Kathleen M. Trybus;Dongchuan Guo;Lee L. Sweeney

  • Myosin V from head to tail.

    Kathleen M. Trybus

  • Two heads of myosin are better than one for generating force and motion

    M. J. Tyska;D. E. Dupuis;W. H. Guilford;J. B. Patlak

  • Differential Labeling of Myosin V Heads with Quantum Dots Allows Direct Visualization of Hand-Over-Hand Processivity

    David M. Warshaw;Guy G. Kennedy;Steven S. Work;Elena B. Krementsova

  • Spare the rod, spoil the regulation: Necessity for a myosin rod

    Kathleen M. Trybus;Yelena Freyzon;Lynn Z. Faust;H. Lee Sweeney

  • Myosin Va maneuvers through actin intersections and diffuses along microtubules.

    M. Yusuf Ali;Elena B. Krementsova;Guy G. Kennedy;Rachel Mahaffy

  • Evidence for cleft closure in actomyosin upon ADP release

    Niels Volkmann;Dorit Hanein;Greta Ouyang;Kathleen M. Trybus

  • Crystal Structures of Expressed Non-polymerizable Monomeric Actin in the ADP and ATP States *

    Mark A. Rould;Qun Wan;Peteranne B. Joel;Susan Lowey

  • Myosin V processivity: Multiple kinetic pathways for head-to-head coordination

    Josh E. Baker;Elena B. Krementsova;Guy G. Kennedy;Amy Armstrong

  • Myosin V and Kinesin act as tethers to enhance each others' processivity

    M. Yusuf Ali;Hailong Lu;Carol S. Bookwalter;David M. Warshaw

  • Alpha-cardiac actin mutations produce atrial septal defects

    Hans Matsson;Jacqueline Eason;Carol S. Bookwalter;Joakim Klar

  • The essential light chain is required for full force production by skeletal muscle myosin.

    Peter Vanburen;Guillermina S. Waller;David E. Harris;Kathleen M. Trybus

  • Crystal structure of apo-calmodulin bound to the first two IQ motifs of myosin V reveals essential recognition features

    Anne Houdusse;Jean-François Gaucher;Elena Krementsova;Suet Mui

  • Charge replacement near the phosphorylatable serine of the myosin regulatory light chain mimics aspects of phosphorylation.

    H. L. Sweeney;Zhaohui Yang;Gang Zhi;J. T. Stull

Frequent Co-Authors

David M. Warshaw
David M. Warshaw University of Vermont
Anne Houdusse
Anne Houdusse Université Paris Cité
Trina A. Schroer
Trina A. Schroer Johns Hopkins University
Jake Baum
Jake Baum University of New South Wales
H. Lee Sweeney
H. Lee Sweeney University of Florida
Yi Lu
Yi Lu University of Illinois at Urbana-Champaign
Dianna M. Milewicz
Dianna M. Milewicz The University of Texas Health Science Center at Houston
David J. DeRosier
David J. DeRosier Brandeis University
Jeffrey Robbins
Jeffrey Robbins Cincinnati Children's Hospital Medical Center
Jun Liu
Jun Liu Yale University

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