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Biology and Biochemistry

D-Index
72
Citations
18202
World Ranking
6315
National Ranking
2959

Research.com Recognitions

  • 2017 - Member of the National Academy of Sciences
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Yale E. Goldman is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions in the subfields of Molecular Biology, Cardiology and Cardiovascular Medicine, Biomedical Engineering, Biophysics, and Cell Biology.

The main topics covered by their research include:

  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Cardiomyopathy and Myosin Studies
  • Cardiovascular Effects of Exercise
  • Muscle Physiology and Disorders
  • Advanced Fluorescence Microscopy Techniques

Yale E. Goldman has published extensively in notable scientific venues, including:

  • Biophysical Journal (24 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (9 publications)
  • Proceedings of the National Academy of Sciences (2 publications)
  • Nature Communications (2 publications)
  • Journal of Biological Chemistry (2 publications)

Among their recent papers are:

  • "Sexually dimorphic RNA helicases DDX3X and DDX3Y differentially regulate RNA metabolism through phase separation" (2022, Molecular Cell)
  • "Ataluren and aminoglycosides stimulate read-through of nonsense codons by orthogonal mechanisms" (2021, Proceedings of the National Academy of Sciences)
  • "Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil" (2021, eLife)
  • "Ataluren binds to multiple protein synthesis apparatus sites and competitively inhibits release factor-dependent termination" (2022, Nature Communications)
  • "Straightening Out the Elasticity of Myosin Cross-Bridges" (2020, Biophysical Journal)

The frequent collaborators of Yale E. Goldman include:

  • Barry S. Cooperman (14 joint publications)
  • E. Michael Ostap (14 joint publications)
  • Donald A. Winkelmann (11 joint publications)
  • A.A. Bhattacharya (11 joint publications)
  • Him Shweta (11 joint publications)

Yale E. Goldman has been recognized with several awards, such as becoming a Member of the National Academy of Sciences in 2017 and a Fellow of the American Association for the Advancement of Science (AAAS) in 2007.

Best Publications

  • Myosin V Walks Hand-Over-Hand: Single Fluorophore Imaging with 1.5-nm Localization

    Ahmet Yildiz;Joseph N. Forkey;Sean A. McKinney;Taekjip Ha;Taekjip Ha

  • Differential regulation of dynein and kinesin motor proteins by tau.

    Ram Dixit;Jennifer L. Ross;Yale E. Goldman;Erika L. F. Holzbaur

  • Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization

    Joseph N. Forkey;Margot E. Quinlan;M. Alexander Shaw;John E. T. Corrie

  • Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate.

    J. W. Walker;A. V. Somlyo;Y. E. Goldman;A. P. Somlyo

  • Phosphate release and force generation in skeletal muscle fibers

    Mark G. Hibberd;Jody A. Dantzig;David R. Trentham;Yale E. Goldman

  • Excitation-contraction coupling in heart muscle: Membrane control of development of tension

    M. Morad;Y. Goldman

  • A small-molecule inhibitor of skeletal muscle myosin II.

    A Cheung;J A Dantzig;S Hollingworth;S M Baylor

  • Processive bidirectional motion of dynein-dynactin complexes in vitro.

    Jennifer L. Ross;Karen Wallace;Henry Shuman;Yale E. Goldman

  • Relaxation of rabbit psoas muscle fibres from rigor by photochemical generation of adenosine-5'-triphosphate.

    Y E Goldman;M G Hibberd;D R Trentham

  • Compliance of thin filaments in skinned fibers of rabbit skeletal muscle.

    H. Higuchi;T. Yanagida;Y.E. Goldman

  • Kinetics of the actomyosin ATPase in muscle fibers.

    Yale E. Goldman

  • Dynamic measurement of myosin light-chain-domain tilt and twist in muscle contraction

    J. E. T. Corrie;B. D. Brandmeier;R. E. Ferguson;D. R. Trentham

  • Tilting of the light-chain region of myosin during step length changes and active force generation in skeletal muscle

    M. Irving;T. St Claire Allen;C. Sabido-David;J. S. Craik

  • Microtubule plus-end tracking by CLIP-170 requires EB1

    Ram Dixit;Brian Barnett;Jacob E. Lazarus;Mariko Tokito

  • Force Generation in Single Conventional Actomyosin Complexes under High Dynamic Load

    Yasuharu Takagi;Earl E. Homsher;Yale E. Goldman;Henry Shuman

  • Force measurements on cargoes in living cells reveal collective dynamics of microtubule motors

    Adam G. Hendricks;Erika L. F. Holzbaur;Yale E. Goldman

  • Wag the Tail: Structural Dynamics of Actomyosin

    Yale E Goldman

  • Trading force for speed: Why superfast crossbridge kinetics leads to superlow forces

    Lawrence C. Rome;Chris Cook;Douglas A. Syme;Martin A. Connaughton

  • Cross-bridge kinetics, cooperativity, and negatively strained cross-bridges in vertebrate smooth muscle. A laser-flash photolysis study.

    Avril V. Somlyo;Yale E. Goldman;Taro Fujimori;Meredith Bond

  • Rapid photochemical inactivation of Ca2+-antagonists shows that Ca2+ entry directly activates contraction in frog heart.

    M. Morad;Y. E. Goldman;D. R. Trentham

Frequent Co-Authors

Barry S. Cooperman
Barry S. Cooperman University of Pennsylvania
Erika L.F. Holzbaur
Erika L.F. Holzbaur University of Pennsylvania
Clara Franzini-Armstrong
Clara Franzini-Armstrong University of Pennsylvania
Michael J. Greenberg
Michael J. Greenberg Washington University in St. Louis
Russell J. Composto
Russell J. Composto University of Pennsylvania
David R. Trentham
David R. Trentham King's College London
Haim H. Bau
Haim H. Bau University of Pennsylvania
Mitsuo Ikebe
Mitsuo Ikebe University of Massachusetts Chan Medical School
Harry W. Schroeder
Harry W. Schroeder University of Alabama at Birmingham
Malcolm Irving
Malcolm Irving King's College London

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