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D-Index & Metrics

Biology and Biochemistry

D-Index
90
Citations
32253
World Ranking
2425
National Ranking
1286

Research.com Recognitions

  • 2009 - Fellow of the Mineralogical Society of America
  • 1998 - Distinguished Scientist Award, Mineralogical Society of America

Overview

Avril V. Somlyo is affiliated with the University of Virginia in the United States. Their research spans several fields primarily within biochemistry, genetics, molecular biology, and medicine, with specific focus on molecular biology, physiology, cell biology, immunology, and cardiology and cardiovascular medicine.

Their work frequently addresses topics such as protein kinase regulation and GTPase signaling, muscle physiology and disorders, cardiomyopathy and myosin studies, mitochondrial function and pathology, connexins and lens biology, calpain protease function and regulation, and biomarkers in disease mechanisms.

Somlyo has published in multiple scientific venues, with notable recurring publications in Circulation and UNC Libraries, alongside contributions to bioRxiv (Cold Spring Harbor Laboratory), Science Signaling, and Frontiers in Physiology.

  • Pannexin-3 stabilizes the transcription factor Bcl6 in a channel-independent manner to protect against vascular oxidative stress, 2024, Science Signaling
  • p90RSK2, a new MLCK mediates contractility in myosin light chain kinase null smooth muscle, 2023, Frontiers in Physiology
  • Smooth and Cardiac Muscle-selective Knock-out of Krüppel-like Factor 4 Causes Postnatal Death and Growth Retardation, 2020, UNC Libraries
  • Abstract 14369: Smooth Muscle Specific Deletion of RSK2 Suppresses Vasoconstriction of Resistance Arteries, 2021, Circulation
  • Abstract P333: Influence Of RSK2 On Blood Pressure In Aging, 2022, Hypertension

Collaborations with other researchers have been significant in Somlyo's work. Frequent co-authors include Ramon J. Ayon, Swapnil K. Sonkusare, Jaspreet Kalra, Yves T. Wang, and Thu H. Le.

Throughout their career, Somlyo has been recognized by the Mineralogical Society of America, receiving the Distinguished Scientist Award in 1998 and being named a Fellow in 2009.

Best Publications

  • Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase

    Andrew P. Somlyo;Avril V. Somlyo

  • Signal transduction and regulation in smooth muscle

    Andrew P. Somlyo;Avril V. Somlyo

  • Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

    Andrew P. Somlyo;Avril V. Somlyo

  • SARCOPLASMIC RETICULUM AND EXCITATION-CONTRACTION COUPLING IN MAMMALIAN SMOOTH MUSCLES

    Carrick E. Devine;Avril V. Somlyo;Andrew P. Somlyo

  • ELECTROMECHANICAL AND PHARMACOMECHANICAL COUPLING IN VASCULAR SMOOTH MUSCLE

    Avril V. Somlyo;Andrew P. Somlyo

  • Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+.

    T Kitazawa;S Kobayashi;K Horiuti;A V Somlyo

  • Calcium release and ionic changes in the sarcoplasmic reticulum of tetanized muscle: an electron-probe study.

    A V Somlyo;H G Gonzalez-Serratos;H Shuman;G McClellan

  • Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization.

    Christopher P. Mack;Avril V. Somlyo;Martina Hautmann;Andrew P. Somlyo

  • Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle

    Avril V. Somlyo;Meredith Bond;Andrew P. Somlyo;Antonio Scarpa

  • Quantitative electron probe microanalysis of biological thin sections: methods and validity.

    Henry Shuman;Avril V. Somlyo;Andrew P. Somlyo

  • Cytosolic heparin inhibits muscarinic and alpha-adrenergic Ca2+ release in smooth muscle. Physiological role of inositol 1,4,5-trisphosphate in pharmacomechanical coupling.

    S Kobayashi;T Kitazawa;A V Somlyo;A P Somlyo

  • Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo

    A. P. Somlyo;Meredith Bond;Avril V. Somlyo

  • Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner.

    Diem H.D. Nguyen;Andrew D. Catling;Donna J. Webb;Mauricio Sankovic

  • Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate.

    J. W. Walker;A. V. Somlyo;Y. E. Goldman;A. P. Somlyo

  • Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells.

    Avril V. Somlyo;Dawn Bradshaw;Susan Ramos;Cheryl Murphy

  • Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle

    M C Gong;K Iizuka;G Nixon;J P Browne

  • Elemental distribution in striated muscle and the effects of hypertonicity. Electron probe analysis of cryo sections.

    AV Somlyo;H Shuman;AP Somlyo

  • Electron probe analysis of vascular smooth muscle. Composition of mitochondria, nuclei, and cytoplasm.

    A P Somlyo;A V Somlyo;H Shuman

  • Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium

    Ming Cui Gong;A. Fuglsang;D. Alessi;S. Kobayashi

  • Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle

    Ming Cui Gong;Hideyoshi Fujihara;Avril V. Somlyo;Andrew P. Somlyo

Frequent Co-Authors

Zygmunt S. Derewenda
Zygmunt S. Derewenda University of Virginia
Gary K. Owens
Gary K. Owens University of Virginia
Timothy A. J. Haystead
Timothy A. J. Haystead Duke University
David R. Trentham
David R. Trentham King's College London
Zhifeng Shao
Zhifeng Shao Shanghai Jiao Tong University
Brant E. Isakson
Brant E. Isakson University of Virginia
Yale E. Goldman
Yale E. Goldman University of Pennsylvania
Steven L. Gonias
Steven L. Gonias University of California, San Diego
Clara Franzini-Armstrong
Clara Franzini-Armstrong University of Pennsylvania

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