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Biology and Biochemistry

D-Index
53
Citations
9702
World Ranking
16205
National Ranking
6714

Overview

Anna Plaas is affiliated with Rush University Medical Center in the United States and conducts research primarily in the fields of Medicine as well as Biochemistry, Genetics and Molecular Biology.

Their work spans several subfields, including Surgery, Rheumatology, Cell Biology, Immunology, and Genetics. The main research topics addressed include Proteoglycans and Glycosaminoglycans Research, Osteoarthritis Treatment and Mechanisms, Cell Adhesion Molecules Research, Immune Response and Inflammation, Dermatological and Skeletal Disorders, Inflammatory Myopathies and Dermatomyositis, and Heterotopic Ossification and Related Conditions.

Among recent publications, notable papers include:

  • "Calcinosis in Systemic Sclerosis: Updates in Pathophysiology, Evaluation, and Treatment" (2020), published in Current Rheumatology Reports
  • "Aggrecan and Hyaluronan: The Infamous Cartilage Polyelectrolytes - Then and Now" (2023), published in Advances in Experimental Medicine and Biology
  • "Addition of High Molecular Weight Hyaluronic Acid to Fibroblast-Like Stromal Cells Modulates Endogenous Hyaluronic Acid Metabolism and Enhances Proteolytic Processing and Secretion of Versican" (2020), published in Cells
  • "The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats" (2020), published in The FASEB Journal
  • "Contrast-enhanced micro-computed tomography of compartment and time-dependent changes in femoral cartilage and subchondral plate in a murine model of osteoarthritis" (2022), published in The Anatomical Record

Frequent co-authors in Anna Plaas's work include:

  • Jun Li
  • Meghan M. Moran
  • Deva D. Chan
  • Dale R. Sumner
  • Quan Shen

They have published multiple papers in venues such as bioRxiv (Cold Spring Harbor Laboratory), Current Rheumatology Reports, Advances in Experimental Medicine and Biology, Cells, and The FASEB Journal.

The research contributions focus on the biochemical and cellular mechanisms underlying connective tissue diseases and orthopedic conditions, with particular attention to extracellular matrix components like proteoglycans and glycosaminoglycans. Their investigations often intersect with immunological responses and inflammatory processes.

Best Publications

  • Biosynthetic response of cartilage explants to dynamic compression.

    R. L.-Y. Sah;Young-Jo Kim;J.-Y. H. Doong;A. J. Grodzinsky

  • Mechanical Regulation of Cartilage Biosynthetic Behavior: Physical Stimuli

    Young-Jo Kim;Robert L. Y. Sah;Alan J. Grodzinsky;Anna H. K. Plaas

  • Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

    Carla R Scanzello;Anna Plaas;Mary K Crow

  • Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44

    Hiroto Kawashima;Mayumi Hirose;Jun Hirose;Daisuke Nagakubo

  • Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy

    Laurel Ng;Alan J. Grodzinsky;Parth Patwari;John Sandy

  • ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated Proteinase to Chondroitin Sulfate and Heparan Sulfate on Syndecan-1 *

    Gui Gao;Anna H. Plaas;Vivian P. Thompson;Sue Jin

  • Effects of compression on the loss of newly synthesized proteoglycans and proteins from cartilage explants.

    Robert L-Y. Sah;Joe-Yuan H. Doong;Alan J. Grodzinsky;Anna H.K. Plaas

  • Glycosaminoglycan Sulfation in Human Osteoarthritis DISEASE-RELATED ALTERATIONS AT THE NON-REDUCING TERMINI OF CHONDROITIN AND DERMATAN SULFATE

    Anna H.K. Plaas;Leigh A. West;Shirley Wong-Palms;Fred R.T. Nelson

  • In Vivo and in Vitro Stimulation of Chondrocyte Biosynthetic Activity in Early Experimental Osteoarthritis

    John D. Sandy;Mark E. Adams;Michael E. J. Billingham;Anna Plaas

  • Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilage.

    Gabriella Cs-Szabó;Peter J. Roughley;Anna H. K. Plaas;Tibor T. Glant

  • Chemical and Immunological Assay of the Nonreducing Terminal Residues of Chondroitin Sulfate from Human Aggrecan

    Anna H K Plaas;Anna H K Plaas;Shirley Wong-Palms;Peter J. Roughley;Ronald Joseph Midura

  • Variations in matrix composition and GAG fine structure among scaffolds for cartilage tissue engineering

    J. K. Mouw;J. K. Mouw;N. D. Case;N. D. Case;R. E. Guldberg;R. E. Guldberg;A. H K Plaas

  • Proteoglycans of human rotator cuff tendons.

    Matthew C. Berenson;Field T. Blevins;Anna H. K. Plaas;Kathryn G. Vogel

  • Synovial fluid levels and serum pharmacokinetics in a large animal model following treatment with oral glucosamine at clinically relevant doses.

    Sheila Laverty;John D. Sandy;Christophe Celeste;Pascal Vachon

  • Identification of the keratan sulfate attachment sites on bovine fibromodulin.

    A. H. K. Plaas;P. J. Neame;C. M. Nivens;L. Reiss

  • Direct Measurement of Glycosaminoglycan Intermolecular Interactions via High-Resolution Force Spectroscopy

    J. Seog;D. Dean;A. H. K. Plaas;S. Wong-Palms

  • Fluorophore-assisted carbohydrate electrophoresis (FACE) of glycosaminoglycans

    A. Calabro;Ronald Joseph Midura;Ronald Joseph Midura;Aimin Wang;Aimin Wang;L. West;L. West

  • Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5-hyaluronan complexes in articular cartilages.

    A. Plaas;B. Osborn;Y. Yoshihara;Y. Yoshihara;Y. Bai

  • Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor α in immature bovine and adult human articular cartilage

    Yihong Sui;Jennifer H. Lee;Michael A. DiMicco;Eric J. Vanderploeg

  • The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis.

    Susanne X. Wang;Sheila Laverty;Mircea Dumitriu;Anna Plaas

Frequent Co-Authors

John D. Sandy
John D. Sandy Rush University Medical Center
Vincent C. Hascall
Vincent C. Hascall Cleveland Clinic
Jorge O. Galante
Jorge O. Galante Rush University Medical Center
Katalin Mikecz
Katalin Mikecz Rush University Medical Center
Brian J. Cole
Brian J. Cole Rush University Medical Center
Anthony J. Day
Anthony J. Day University of Manchester
Robert L. Sah
Robert L. Sah University of California, San Diego
Amanda J. Fosang
Amanda J. Fosang Royal Children's Hospital

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