World's Best Scientists 2026 revealed!
Vincent C. Hascall

Vincent C. Hascall

D-Index & Metrics

Chemistry

D-Index
91
Citations
25180
World Ranking
2005
National Ranking
731

Biology and Biochemistry

D-Index
97
Citations
29203
World Ranking
1775
National Ranking
981

Overview

Vincent C. Hascall is affiliated with the Cleveland Clinic in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans various subfields including cell biology, molecular biology, neurology, cancer research, and oncology. A significant portion of their research focuses on proteoglycans and glycosaminoglycans, as well as neurovascular disturbances related to traumatic brain injury.

The scientist's recent work includes several publications across reputable journals. Notable papers include:

  • Sirtuin 1 reduces hyaluronan synthase 2 expression by inhibiting nuclear translocation of NF-κB and expression of the long-noncoding RNA HAS2-AS1 (2020, Journal of Biological Chemistry)
  • Extracellular Superoxide Dismutase Regulates Early Vascular Hyaluronan Remodeling in Hypoxic Pulmonary Hypertension (2020, Scientific Reports)
  • Heparin inhibits proinflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress (2020, Journal of Biological Chemistry)
  • Chemotherapy induces feedback up-regulation of CD44v6 in colorectal cancer initiating cells through β-catenin/MDR1 signaling to sustain chemoresistance (2022, Frontiers in Oncology)
  • FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells (2021, International Journal of Molecular Sciences)

Several frequent co-authors have collaborated with Vincent C. Hascall, including Aimin Wang, Sudan Puri, Vivien J. Coulson-Thomas, Shibnath Ghatak, and Roger R. Markwald.

The scientist's publications are predominantly found in the Journal of Biological Chemistry, with eight articles, followed by the American Journal Of Pathology and Research Square, each hosting four of their works. Additional publications appear in Frontiers in Oncology and Scientific Reports.

Research topics covered by their work include:

  • Proteoglycans and glycosaminoglycans research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Fibroblast Growth Factor Research
  • Advanced Glycation End Products research
  • Wnt/β-catenin signaling in development and cancer
  • Cancer Cells and Metastasis
  • Osteoarthritis Treatment and Mechanisms

Best Publications

  • Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

    Suniti Misra;Vincent C. Hascall;Roger R. Markwald;Shibnath Ghatak

  • Aggregation of Cartilage Proteoglycans I. THE ROLE OF HYALURONIC ACID

    Vincent C. Hascall;Dick Heinegård

  • Aggregation of Cartilage Proteoglycans: III. CHARACTERISTICS OF THE PROTEINS ISOLATED FROM TRYPSIN DIGESTS OF AGGREGATES

    Dick Heinegård;Vincent C. Hascall

  • HYALURONAN BINDING BY CELL SURFACE CD44

    Jayne Lesley;Vincent C. Hascall;Markku Tammi;Robert Hyman

  • Hyaluronan–CD44 interactions as potential targets for cancer therapy

    Suniti Misra;Paraskevi Heldin;Vincent C. Hascall;Nikos K. Karamanos

  • Proteoglycan core protein families.

    John R. Hassell;James H. Kimura;Vincent C. Hascall

  • Aggregation of cartilage proteoglycans. II. Oligosaccharide competitors of the proteoglycan-hyaluronic acid interaction.

    Vincent C. Hascall;Dick Heinegård

  • Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice

    Csaba Fülöp;Sándor Szántó;Durba Mukhopadhyay;Tamás Bárdos

  • Mononuclear Leukocytes Bind to Specific Hyaluronan Structures on Colon Mucosal Smooth Muscle Cells Treated with Polyinosinic Acid:Polycytidylic Acid : Inter-α-Trypsin Inhibitor Is Crucial to Structure and Function

    Carol A. de la Motte;Vincent C. Hascall;Judith Drazba;Sudip K. Bandyopadhyay

  • Proteoglycans of developing bone.

    L W Fisher;J D Termine;S W Dejter;S W Whitson

  • Insulin-like growth factors maintain steady-state metabolism of proteoglycans in bovine articular cartilage explants

    Frank P. Luyten;Vincent C. Hascall;S.Peter Nissley;Teresa I. Morales

  • Intracellular hyaluronan: a new frontier for inflammation?

    Vincent C Hascall;Alana K Majors;Carol A De La Motte;Stephen P Evanko

  • Synthesis and accumulation of hyaluronic acid and proteoglycans in the mouse cumulus cell-oocyte complex during follicle-stimulating hormone-induced mucification.

    A Salustri;M Yanagishita;V C Hascall

  • Hyaluronan Enters Keratinocytes by a Novel Endocytic Route for Catabolism

    Raija H. Tammi;Raija H. Tammi;Kirsi Rilla;Juha-Pekka Pienimäki;Donald K. MacCallum

  • Physical Properties and Polydispersity of Proteoglycan from Bovine Nasal Cartilage

    Unknown

  • Inter-α-trypsin Inhibitor, a Covalent Protein-Glycosaminoglycan-Protein Complex *

    Lisheng Zhuo;Vincent C. Hascall;Koji Kimata

  • Partial characterization of newly synthesized proteoglycans isolated from the glomerular basement membrane.

    Y S Kanwar;V C Hascall;M G Farquhar

  • Microanalysis of enzyme digests of hyaluronan and chondroitin/dermatan sulfate by fluorophore-assisted carbohydrate electrophoresis (FACE).

    Anthony Calabro;Maria Benavides;Markku Tammi;Vincent C Hascall

  • Cell-surface heparan sulfate proteoglycan mediates HIV-1 infection of T-cell lines.

    Unknown

  • Biosynthesis of proteoglycans and their assembly into aggregates in cultures of chondrocytes from the Swarm rat chondrosarcoma.

    J H Kimura;T E Hardingham;V C Hascall;M Solursh

  • Mononuclear Leukocytes Preferentially Bind via CD44 to Hyaluronan on Human Intestinal Mucosal Smooth Muscle Cells after Virus Infection or Treatment with Poly(I·C)

    Carol A. de la Motte;Vincent C. Hascall;Anthony Calabro;Belinda Yen-Lieberman

  • Hyaluronan Synthases*

    Unknown

  • Chapter 25 – The Hyaluronan Synthases

    Paul H. Weigel

Frequent Co-Authors

Carol A. de la Motte
Carol A. de la Motte Cleveland Clinic
Markku Tammi
Markku Tammi University of Eastern Finland
Roger R. Markwald
Roger R. Markwald Medical University of South Carolina
Raija Tammi
Raija Tammi University of Eastern Finland
Alberto Passi
Alberto Passi University of Insubria
Masaki Yanagishita
Masaki Yanagishita Tokyo Medical and Dental University
Anna Plaas
Anna Plaas Rush University Medical Center
Anthony J. Day
Anthony J. Day University of Manchester
Nikos K. Karamanos
Nikos K. Karamanos University of Patras
Serpil C. Erzurum
Serpil C. Erzurum Cleveland Clinic Lerner College of Medicine

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