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Biology and Biochemistry
Japan
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
32448
World Ranking
1023
National Ranking
54

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2025 - Research.com Biology and Biochemistry in Japan Leader Award
  • 2023 - Research.com Biology and Biochemistry in Japan Leader Award

Overview

Koji Kimata is affiliated with Aichi Medical University in Japan and has an academic focus primarily on the fields of Biochemistry, Genetics and Molecular Biology, along with Medicine. Their research engages with subfields such as Molecular Biology, Cell Biology, Rheumatology, Organic Chemistry, and Cancer Research.

The scientist's publication record includes work in several frequent venues, demonstrating a sustained contribution to journals like the Journal of Orthopaedic Research®, Glycobiology, Journal of Biological Chemistry, International Journal of Molecular Sciences, and Molecular Pain.

Research topics explored by Koji Kimata encompass:

  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and Glycoproteins Research
  • Fibroblast Growth Factor Research
  • Carbohydrate Chemistry and Synthesis
  • Protease and Inhibitor Mechanisms
  • Phytochemical compounds biological activities
  • Peptidase Inhibition and Analysis

Collaborations and frequent co-authorship involve multiple researchers, including Lisheng Zhuo, Hiroshi Koike, Yoshihiro Nishida, Takahiro Ushida, and Hideo Mochizuki.

Recent papers include:

  • A quantitative method to detect non-antithrombin-binding 3-O-sulfated units in heparan sulfate, 2020, Journal of Biological Chemistry
  • Possible Repositioning of an Oral Anti-Osteoporotic Drug, Ipriflavone, for Treatment of Inflammatory Arthritis via Inhibitory Activity of KIAA1199, a Novel Potent Hyaluronidase, 2022, International Journal of Molecular Sciences
  • Forced expression of KIAA1199, a novel hyaluronidase, inhibits tumorigenicity of low-grade chondrosarcoma, 2020, Journal of Orthopaedic Research®
  • Knockout of the intellectual disability-linked gene Hs6st2 in mice decreases heparan sulfate 6-O-sulfation, impairs dendritic spines of hippocampal neurons, and affects memory, 2023, Glycobiology
  • Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head, 2022, Journal of Orthopaedic Research®

Best Publications

  • Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties

    Naoki Itano;Takahiro Sawai;Mamoru Yoshida;Petros Lenas

  • Proteoglycans and Sulfated Glycosaminoglycans

    Jeffrey D Esko;Koji Kimata;Ulf Lindahl

  • A chondrogenic cell line derived from a differentiating culture of AT805 teratocarcinoma cells.

    Tadao Atsumi;Yoji Ikawa;Yoko Miwa;Koji Kimata

  • Mammalian hyaluronan synthases.

    Naoki Itano;Koji Kimata

  • The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

    A. D. Snow;H. Mar;D. Nochlin;K. Kimata

  • Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments.

    K M Yamada;D W Kennedy;K Kimata;R M Pratt

  • An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

    Alan D. Snow;Raymond Sekiguchi;David Nochlin;Paul Fraser

  • Roles of Aggrecan, a Large Chondroitin Sulfate Proteoglycan, in Cartilage Structure and Function

    Hideto Watanabe;Yoshihiko Yamada;Koji Kimata

  • Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.

    Naoki Itano;Fukiko Atsumi;Takahiro Sawai;Yoichi Yamada

  • Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library.

    Satoko Ashikari-Hada;Hiroko Habuchi;Yutaka Kariya;Nobuyuki Itoh

  • Structural analysis of chick-embryo cartilage proteoglycan by selective degradation with chondroitin lyases (chondroitinases) and endo-beta-D-galactosidase (keratanase).

    Y Oike;K Kimata;T Shinomura;K Nakazawa

  • Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome.

    A D Snow;H Mar;D Nochlin;R T Sekiguchi

  • A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone.

    Ikuko Kakizaki;Kaoru Kojima;Keiichi Takagaki;Masahiko Endo

  • The Occurrence of Three Isoforms of Heparan Sulfate 6-O-Sulfotransferase Having Different Specificities for Hexuronic Acid Adjacent to the TargetedN-Sulfoglucosamine

    Hiroko Habuchi;Masayuki Tanaka;Osami Habuchi;Keiichi Yoshida

  • Inter-α-trypsin Inhibitor, a Covalent Protein-Glycosaminoglycan-Protein Complex *

    Lisheng Zhuo;Vincent C. Hascall;Koji Kimata

  • Defect in SHAP-Hyaluronan Complex Causes Severe Female Infertility: A STUDY BY INACTIVATION OF THE BIKUNIN GENE IN MICE *

    Lisheng Zhuo;Masahiko Yoneda;Ming Zhao;Wannarat Yingsung

  • Regulation of cell-substrate adhesion by proteoglycans immobilized on extracellular substrates.

    M Yamagata;S Suzuki;S K Akiyama;K M Yamada

  • Mouse cartilage matrix deficiency ( cmd ) caused by a 7 bp deletion in the aggrecan gene

    Hideto Watanabe;Koji Kimata;Sergio Line;Dave Strong

  • Sulfation pattern in glycosaminoglycan: does it have a code?

    Hiroko Habuchi;Osami Habuchi;Koji Kimata

  • Relationship between Hyaluronan Production and Metastatic Potential of Mouse Mammary Carcinoma Cells

    Naoki Itano;Takahiro Sawai;Osamu Miyaishi;Koji Kimata

Frequent Co-Authors

Hisashi Narimatsu
Hisashi Narimatsu National Institute of Advanced Industrial Science and Technology
Naoki Ishiguro
Naoki Ishiguro Nagoya University
Takashi Kudo
Takashi Kudo University of Tsukuba
Jeffrey D. Esko
Jeffrey D. Esko University of California, San Diego
Ulf Lindahl
Ulf Lindahl Uppsala University
Hiroko Iwasaki
Hiroko Iwasaki Keio University
Shun'ichiro Taniguchi
Shun'ichiro Taniguchi Shinshu University
Yoshihiko Yamada
Yoshihiko Yamada National Institutes of Health
Thomas N. Wight
Thomas N. Wight Virginia Mason Medical Center
Yoichi M. A. Yamada
Yoichi M. A. Yamada Kyushu University

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