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Biology and Biochemistry

D-Index
116
Citations
41012
World Ranking
769
National Ranking
484

Overview

Thomas N. Wight is affiliated with Virginia Mason Medical Center in the United States and focuses on research in biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work spans multiple subfields including cell biology, molecular biology, surgery, immunology, and pulmonary and respiratory medicine.

The scientist's primary research topics include proteoglycans and glycosaminoglycans research, glycosylation and glycoproteins research, fibroblast growth factor research, pancreatic function and diabetes, respiratory viral infections research, connective tissue disorders research, and protease and inhibitor mechanisms.

Thomas N. Wight has published extensively, with notable recent papers including:

  • Versican-A Critical Extracellular Matrix Regulator of Immunity and Inflammation, 2020, Frontiers in Immunology
  • Exuberant fibroblast activity compromises lung function via ADAMTS4, 2020, Nature
  • Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity, 2020, Cell Reports
  • Hypothalamic perineuronal net assembly is required for sustained diabetes remission induced by fibroblast growth factor 1 in rats, 2020, Nature Metabolism
  • Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination, 2022, Nature Communications

Frequent co-authors collaborating with Thomas N. Wight include:

  • Nadine Nagy
  • Paul L. Bollyky
  • Gernot Kaber
  • Christina K. Chan
  • Inkyung Kang

Key publication venues with multiple works by Thomas N. Wight are:

  • Journal of Histochemistry & Cytochemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • JCI Insight
  • Matrix Biology
  • Frontiers in Immunology

Best Publications

  • Human tissue-engineered blood vessels for adult arterial revascularization

    Nicolas L'Heureux;Nathalie Dusserre;Gerhardt Konig;Braden Victor

  • The extracellular matrix: an active or passive player in fibrosis?

    Thomas N. Wight;Susan Potter-Perigo

  • Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy

    Hannu Järveläinen;Annele Sainio;Markku Koulu;Thomas N. Wight

  • Versican: a versatile extracellular matrix proteoglycan in cell biology

    Thomas N Wight

  • Hyaluronan-cell interactions in cancer and vascular disease.

    Bryan P. Toole;Thomas N. Wight;Markku I. Tammi

  • Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells

    Stephen P. Evanko;John C. Angello;Thomas N. Wight

  • Cell biology of arterial proteoglycans.

    T N Wight

  • Early human atherosclerosis : Accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration

    Yutaka Nakashima;Hiroshi Fujii;Shinji Sumiyoshi;Thomas N. Wight

  • Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.

    John D. Sandy;Jennifer Westling;Richard D. Kenagy;M. Luisa Iruela-Arispe

  • The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

    A. D. Snow;H. Mar;D. Nochlin;K. Kimata

  • Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.

    Igor Halpert;Ulrike I. Sires;Jill D. Roby;Susan Potter-Perigo

  • The role of proteoglycans in cell adhesion, migration and proliferation.

    Thomas N. Wight;Michael G. Kinsella;Eva E. Qwarnström

  • Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.

    E Schönherr;H T Järveläinen;L J Sandell;T N Wight

  • Proteoglycans in Atherosclerosis and Restenosis: Key Roles for Versican

    Thomas N. Wight;Mervyn J. Merrilees

  • Human atherosclerosis. I. Cell constitution and characteristics of advanced lesions of the superficial femoral artery.

    R. Ross;T. N. Wight;E. Strandness;B. Thiele

  • Cardiovascular Pathology in Hutchinson-Gilford Progeria: Correlation With the Vascular Pathology of Aging

    Michelle Olive;Ingrid Harten;Richard Mitchell;Jeanette K. Beers

  • Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding.

    J Borén;K Olin;I Lee;A Chait

  • Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

    Robert P.T. Somerville;Jean-Michel Longpre;Katherine A. Jungers;J. Michael Engle

  • Perlecan Binds to the β‐Amyloid Proteins (Aβ) of Alzheimer's Disease, Accelerates Aβ Fibril Formation, and Maintains Aβ Fibril Stability

    Gerardo M. Castillo;Catherine Ngo;Joel Cummings;Thomas N. Wight

  • Early atherosclerosis in humans: Role of diffuse intimal thickening and extracellular matrix proteoglycans

    Yutaka Nakashima;Thomas N. Wight;Thomas N. Wight;Katsuo Sueishi

Frequent Co-Authors

Alan Chait
Alan Chait University of Washington
Alexander W. Clowes
Alexander W. Clowes University of Washington
Peter J. Little
Peter J. Little University of the Sunshine Coast
Charles W. Frevert
Charles W. Frevert University of Washington
Kevin D. O'Brien
Kevin D. O'Brien University of Washington
Steven F. Ziegler
Steven F. Ziegler Virginia Mason Medical Center
Koji Kimata
Koji Kimata Aichi Medical University
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University
Ulf Hedin
Ulf Hedin Karolinska Institute
William A. Banks
William A. Banks University of Washington

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