Extracellular matrix, Proteoglycan, Pathology, Cell biology and Versican are his primary areas of study. His research in Extracellular matrix intersects with topics in Wound healing, Immunology, Restenosis, Anatomy and Coronary arteries. His Proteoglycan study is concerned with Biochemistry in general.
He has researched Pathology in several fields, including Artery and Neointima. His biological study spans a wide range of topics, including Cell culture, Angiogenesis, Cell growth, Cell adhesion and Cell type. His Versican study combines topics from a wide range of disciplines, such as ADAMTS4 Protein, Biglycan, Decorin and Chondroitin sulfate proteoglycan.
Thomas N. Wight focuses on Extracellular matrix, Cell biology, Versican, Proteoglycan and Biochemistry. His Extracellular matrix study incorporates themes from Hyaluronic acid, Immunology, Pathology, Internal medicine and Cell adhesion. His Cell biology research incorporates elements of Cell, Cell migration, CD44, Cell growth and Vascular smooth muscle.
His studies deal with areas such as Elastin, Biglycan, Inflammation, Platelet-derived growth factor receptor and Molecular biology as well as Versican. His study looks at the relationship between Proteoglycan and fields such as Glycosaminoglycan, as well as how they intersect with chemical problems. His work on Chondroitin sulfate, Dermatan sulfate, Heparan sulfate and Chondroitin is typically connected to Chondroitin ABC lyase as part of general Biochemistry study, connecting several disciplines of science.
Extracellular matrix, Versican, Cell biology, Immunology and Internal medicine are his primary areas of study. He interconnects Human lung, Hyaluronic acid, Inflammation, Cell adhesion and Fibroblast in the investigation of issues within Extracellular matrix. Proteoglycan covers Thomas N. Wight research in Versican.
The various areas that Thomas N. Wight examines in his Cell biology study include ADAMTS, Biochemistry, Cell growth and Proteases. His work carried out in the field of Immunology brings together such families of science as Molecular biology, Lung and Hyaluronan synthase. His Internal medicine study combines topics in areas such as Andrology and Endocrinology.
His primary areas of investigation include Extracellular matrix, Immunology, Cell biology, Versican and Inflammation. Thomas N. Wight is interested in Fibronectin, which is a branch of Extracellular matrix. His biological study spans a wide range of topics, including Clotting factor, Cell adhesion, Cell growth and Hyaluronic acid.
The Cell growth study combines topics in areas such as Proteoglycan, Receptor, Regulation of gene expression and Cell migration. In his research on the topic of Hyaluronic acid, Myofibroblast is strongly related with Biochemistry. His study in Versican is interdisciplinary in nature, drawing from both ADAMTS, HAS1, Molecular biology, Innate immune system and Macrophage.
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Human tissue-engineered blood vessels for adult arterial revascularization
Nicolas L'Heureux;Nathalie Dusserre;Gerhardt Konig;Braden Victor.
Nature Medicine (2007)
The extracellular matrix: an active or passive player in fibrosis?
Thomas N. Wight;Susan Potter-Perigo.
American Journal of Physiology-gastrointestinal and Liver Physiology (2011)
Versican: a versatile extracellular matrix proteoglycan in cell biology
Thomas N Wight.
Current Opinion in Cell Biology (2002)
Hyaluronan-cell interactions in cancer and vascular disease.
Bryan P. Toole;Thomas N. Wight;Markku I. Tammi.
Journal of Biological Chemistry (2002)
Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells
Stephen P. Evanko;John C. Angello;Thomas N. Wight.
Arteriosclerosis, Thrombosis, and Vascular Biology (1999)
Cell biology of arterial proteoglycans.
T N Wight.
Arteriosclerosis, Thrombosis, and Vascular Biology (1989)
Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy
Hannu Järveläinen;Annele Sainio;Markku Koulu;Thomas N. Wight.
Pharmacological Reviews (2009)
Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site that is cleaved by recombinant ADAMTS-1 and ADAMTS-4.
John D. Sandy;Jennifer Westling;Richard D. Kenagy;M. Luisa Iruela-Arispe.
Journal of Biological Chemistry (2001)
Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme.
Igor Halpert;Ulrike I. Sires;Jill D. Roby;Susan Potter-Perigo.
Proceedings of the National Academy of Sciences of the United States of America (1996)
The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.
A. D. Snow;H. Mar;D. Nochlin;K. Kimata.
American Journal of Pathology (1988)
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