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Biology and Biochemistry

D-Index
79
Citations
20785
World Ranking
4353
National Ranking
2123

Overview

Suneel S. Apte is affiliated with Case Western Reserve University in the United States. Their research spans multiple disciplines within biomedical science, with a particular focus on molecular mechanisms underlying disease processes.

Their primary fields of study include Medicine and Biochemistry, Genetics and Molecular Biology. Within these broad fields, they have concentrated on subfields such as Molecular Biology, Cell Biology, Genetics, Oncology, and Cancer Research.

The main topics addressed in their work encompass:

  • Proteoglycans and glycosaminoglycans research
  • Protease and Inhibitor Mechanisms
  • Cell Adhesion Molecules Research
  • Connective tissue disorders research
  • Peptidase Inhibition and Analysis
  • Cardiac Fibrosis and Remodeling
  • Congenital heart defects research

Suneel S. Apte has published extensively in scientific venues, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Matrix Biology
  • Osteoarthritis and Cartilage
  • Scientific Reports
  • Journal of Biological Chemistry

Examples of recent publications include:

  • "ADAMTSL5 is an epigenetically activated gene underlying tumorigenesis and drug resistance in hepatocellular carcinoma," 2020, Journal of Hepatology
  • "Aggrecan in Cardiovascular Development and Disease," 2020, Journal of Histochemistry & Cytochemistry
  • "The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche," 2020, Nature Communications
  • "The extracellular matrix glycoprotein ADAMTSL2 is increased in heart failure and inhibits TGFβ signalling in cardiac fibroblasts," 2021, Scientific Reports
  • "Identification of novel ADAMTS1, ADAMTS4 and ADAMTS5 cleavage sites in versican using a label-free quantitative proteomics approach," 2021, Journal of Proteomics

Collaborative efforts are evident in the frequent coauthorship with other researchers including:

  • Daniel R. Martin
  • Sumit Bhutada
  • Timothy J. Mead
  • Karin Tran-Lundmark
  • Christopher D. Koch

Best Publications

  • LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

    Y. Q. Gong;R. B. Slee;N. Fukai;G. Rawadi

  • Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

    Zhongjun Zhou;Suneel S. Apte;Raija Soininen;Renhai Cao

  • A Disintegrin-like and Metalloprotease (Reprolysin-type) with Thrombospondin Type 1 Motif (ADAMTS) Superfamily: Functions and Mechanisms

    Suneel S. Apte

  • Matrix metalloproteinases: old dogs with new tricks.

    Robert P T Somerville;Samantha A. Oblander;Suneel S Apte

  • The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family.

    Suneel S. Apte;Bjorn R. Olsen;Gillian Murphy

  • Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.

    Robert P.T. Somerville;Jean-Michel Longpre;Katherine A. Jungers;J. Michael Engle

  • Inhibition of Angiogenesis by Tissue Inhibitor of Metalloproteinase-3

    Bela Anand-Apte;Michael S. Pepper;Emile Voest;Roberta Montesano

  • A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.

    Suneel S. Apte

  • A type X collagen mutation causes schmid metaphyseal chondrodysplasia

    Matthew L. Warman;Margaret Abbott;Suneel S. Apte;Tim Hefferon

  • Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22

    Suneel S. Apte;Marie Genevieve Mattei;Bjorn R. Olsen

  • Identification and Characterization of a Novel Human Matrix Metalloproteinase with Unique Structural Characteristics, Chromosomal Location, and Tissue Distribution

    Alberto M. Pendás;Vera Knäuper;Xose S. Puente;Elena Llano

  • Procollagen II Amino Propeptide Processing by ADAMTS-3 INSIGHTS ON DERMATOSPARAXIS

    Russell J. Fernandes;Satoshi Hirohata;J. Michael Engle;Alain Colige

  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression

    Daniel R. McCulloch;Courtney M. Nelson;Laura J. Dixon;Debra L. Silver

  • Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues

    Kevin J. Leco;Suneel S. Apte;Gary T. Taniguchi;Susan P. Hawkes

  • ADAMTS proteins in human disorders.

    Timothy J. Mead;Suneel S. Apte

  • Loss of MMP-2 disrupts skeletal and craniofacial development and results in decreased bone mineralization, joint erosion and defects in osteoblast and osteoclast growth

    Rebecca A. Mosig;Oonagh Dowling;Analisa DiFeo;Maria Celeste M. Ramirez

  • ADAM-TS5, ADAM-TS6, and ADAM-TS7, Novel Members of a New Family of Zinc Metalloproteases GENERAL FEATURES AND GENOMIC DISTRIBUTION OF THE ADAM-TS FAMILY ,

    Tiina L. Hurskainen;Satoshi Hirohata;Michael F. Seldin;Suneel S. Apte

  • ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation.

    Carine Le Goff;Fanny Morice-Picard;Nathalie Dagoneau;Lauren W Wang

  • Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium.

    Tara L. Haas;David Stitelman;Sandra J. Davis;Suneel S. Apte

  • Mutations in the TGFβ Binding-Protein-Like Domain 5 of FBN1 Are Responsible for Acromicric and Geleophysic Dysplasias

    Carine Le Goff;Clémentine Mahaut;Lauren W Wang;Slimane Allali

Frequent Co-Authors

Björn Olsen
Björn Olsen Harvard University
Dieter P. Reinhardt
Dieter P. Reinhardt McGill University
Robert S. Haltiwanger
Robert S. Haltiwanger University of Georgia
Michael F. Seldin
Michael F. Seldin University of California, Davis
Richard Leduc
Richard Leduc Université de Sherbrooke
Belinda Willard
Belinda Willard Cleveland Clinic
Bruce Caterson
Bruce Caterson Cardiff University
David E. Birk
David E. Birk University of South Florida
Robert P. Mecham
Robert P. Mecham Washington University in St. Louis
Lynn Y. Sakai
Lynn Y. Sakai Oregon Health & Science University

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