His primary areas of investigation include Fibrillin, Fibrillin Microfibrils, Fibrillin-2, Fibrillins and Marfan syndrome. His research in Fibrillin tackles topics such as Molecular biology which are related to areas like Fibulin. His Fibrillin Microfibrils study is within the categories of Cell biology and Biochemistry.
He has included themes like Elastin, Biophysics, Elastic fiber assembly and Anatomy in his Fibrillin-2 study. Fibrillins is a subfield of Extracellular matrix that Lynn Y. Sakai investigates. His research in Marfan syndrome intersects with topics in Mutation, Missense mutation and Mutant.
His primary scientific interests are in Fibrillin, Cell biology, Fibrillin Microfibrils, Fibrillins and Biochemistry. His Fibrillin-2 study in the realm of Fibrillin interacts with subjects such as Microfibril. His Cell biology research includes elements of Growth factor and Bone morphogenetic protein.
His Fibrillin Microfibrils study also includes fields such as
Lynn Y. Sakai mostly deals with Fibrillin, Marfan syndrome, Pathology, Cell biology and Internal medicine. His Fibrillin Microfibrils and Fibrillins study in the realm of Fibrillin connects with subjects such as Microfibril. His study in Marfan syndrome is interdisciplinary in nature, drawing from both Aneurysm, Aortic aneurysm, Aorta, Pregnancy and Phenotype.
His research in the fields of Connective tissue overlaps with other disciplines such as Tobacco smoke exposure, Fragment and In patient. The Cell biology study combines topics in areas such as Vesicle and Secretion. His Internal medicine research incorporates themes from Endocrinology and Cardiology.
His main research concerns Fibrillin, Marfan syndrome, Cell biology, COPII and Microfibril. Lynn Y. Sakai works on Fibrillin which deals in particular with Elastic fiber assembly. The various areas that Lynn Y. Sakai examines in his Marfan syndrome study include Fibrosis, Pathology and Aortic aneurysm.
His Pathology research incorporates elements of Ex vivo, In vivo, Cardiomyopathy and Anatomy. His Microfibril research overlaps with other disciplines such as Arachnodactyly, Genetics, Weill–Marchesani syndrome, Ectopia lentis and Fibrillin Microfibrils. The study incorporates disciplines such as Mechanotransduction, Fibrillins, Growth factor and Scaffold in addition to Arachnodactyly.
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Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene.
Harry C. Dietz;Carry R. Cutting;Reed E. Pyeritz;Cheryl L. Maslen.
Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome
Enid R. Neptune;Pamela A. Frischmeyer;Dan E. Arking;Loretha Myers.
Nature Genetics (2003)
Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.
Lynn Y. Sakai;Douglas R. Keene;Eva Engvall.
Journal of Cell Biology (1986)
Type VII collagen is a major structural component of anchoring fibrils.
L Y Sakai;D R Keene;N P Morris;R E Burgeson.
Journal of Cell Biology (1986)
Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein
Zenzo Isogai;Robert N. Ono;Shin Ushiro;Douglas R. Keene.
Journal of Biological Chemistry (2003)
Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1
Lygia Pereira;Sui Ying Lee;Barbara Gayraud;Kostantinos Andrikopoulos.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Type VII collagen forms an extended network of anchoring fibrils.
D R Keene;L Y Sakai;G P Lunstrum;N P Morris.
Journal of Cell Biology (1987)
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome
Daniel P. Judge;Nancy J. Biery;Douglas R. Keene;Jessica Geubtner.
Journal of Clinical Investigation (2004)
Immunohistologic abnormalities of the microfibrillar-fiber system in the Marfan syndrome.
David W. Hollister;Maurice Godfrey;Lynn Y. Sakai;Reed E. Pyeritz.
The New England Journal of Medicine (1990)
Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome.
Lygia Pereira;Konstantinos Andrikopoulos;Konstantinos Andrikopoulos;Jenny Tian;Sui Ying Lee.
Nature Genetics (1997)
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