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Biology and Biochemistry

D-Index
84
Citations
26130
World Ranking
3304
National Ranking
1672

Overview

Lynn Y. Sakai is affiliated with Oregon Health & Science University in the United States. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with an emphasis on subfields such as Pulmonary and Respiratory Medicine, Genetics, and Surgery. Their work also extends into areas including Cancer Research and Ophthalmology.

The main topics covered in Sakai's research include connective tissue disorders, aortic aneurysm repair treatments, and aortic disease and treatment approaches. Additional subjects investigated involve protease and inhibitor mechanisms, bone and dental protein studies, infectious aortic and vascular conditions, as well as glaucoma and retinal disorders.

Recent publications by Sakai and their collaborators reveal a focus on cardiovascular and connective tissue pathologies. Notable papers include:

  • "EMILIN1 deficiency causes arterial tortuosity with osteopenia and connects impaired elastogenesis with defective collagen fibrillogenesis" (2022, The American Journal of Human Genetics)
  • "Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models" (2023, Matrix Biology)
  • "An Appealing Story of Sex Differences in Marfan Syndrome" (2023, Canadian Journal of Cardiology)
  • "Novel Aortic Dissection Model Links Endothelial Dysfunction and Immune Infiltration" (2025, Circulation Research)
  • "A Novel Model of Tobacco Smoke-Mediated Aortic Injury" (2021, Vascular and Endovascular Surgery)

Frequent coauthors collaborating with Sakai include:

  • Eric J. Carlson
  • Laura Muiño Mosquera
  • Julie De Backer
  • Patrick Sips
  • Amir F. Azarbal

The scientist's work appears in a range of publication venues, with multiple articles published in the Journal of Vascular Surgery. Other journals where they have contributed include The American Journal of Human Genetics, Matrix Biology, Canadian Journal of Cardiology, and Circulation Research.

Best Publications

  • Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene.

    Harry C. Dietz;Carry R. Cutting;Reed E. Pyeritz;Cheryl L. Maslen

  • Dysregulation of TGF-β activation contributes to pathogenesis in Marfan syndrome

    Enid R. Neptune;Pamela A. Frischmeyer;Dan E. Arking;Loretha Myers

  • Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.

    Lynn Y. Sakai;Douglas R. Keene;Eva Engvall

  • Type VII collagen is a major structural component of anchoring fibrils.

    L Y Sakai;D R Keene;N P Morris;R E Burgeson

  • Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

    Zenzo Isogai;Robert N. Ono;Shin Ushiro;Douglas R. Keene

  • Pathogenetic sequence for aneurysm revealed in mice underexpressing fibrillin-1

    Lygia Pereira;Sui Ying Lee;Barbara Gayraud;Kostantinos Andrikopoulos

  • Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

    Daniel P. Judge;Nancy J. Biery;Douglas R. Keene;Jessica Geubtner

  • Type VII collagen forms an extended network of anchoring fibrils.

    D R Keene;L Y Sakai;G P Lunstrum;N P Morris

  • Immunohistologic abnormalities of the microfibrillar-fiber system in the Marfan syndrome.

    David W. Hollister;Maurice Godfrey;Lynn Y. Sakai;Reed E. Pyeritz

  • Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome.

    Lygia Pereira;Konstantinos Andrikopoulos;Konstantinos Andrikopoulos;Jenny Tian;Sui Ying Lee

  • Four novel FBN1 mutations: significance for mutant transcript level and EGF-like domain calcium binding in the pathogenesis of Marfan syndrome.

    Harry C. Dietz;Iain McIntosh;Lynn Y. Sakai;Lynn Y. Sakai;Glen M. Corson

  • Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils.

    L Y Sakai;D R Keene;R W Glanville;H P Bächinger

  • Fibrillin binds calcium and is coded by cdnas that reveal a multidomain structure and alternatively spliced exons at the 5′ end

    Glen M. Corson;Stephen C. Chalberg;Harry C. Dietz;Noe L. Charbonneau

  • Type III collagen can be present on banded collagen fibrils regardless of fibril diameter.

    D R Keene;L Y Sakai;H P Bächinger;R E Burgeson

  • Mutations in the fibrillin gene responsible for dominant ectopia lentis and neonatal Marfan syndrome

    Katariina Kainulainen;Leena Karttunen;Lea Puhakka;Lynn Sakai

  • Targeting of Bone Morphogenetic Protein Growth Factor Complexes to Fibrillin

    Gerhard Sengle;Noe L. Charbonneau;Robert N. Ono;Takako Sasaki

  • Mutations in Fibrillin-1 Cause Congenital Scleroderma: Stiff Skin Syndrome

    B. L. Loeys;B. L. Loeys;E. E. Gerber;D. Riegert-Johnson;S. Iqbal

  • FBN1: The disease-causing gene for Marfan syndrome and other genetic disorders.

    Lynn Y. Sakai;Douglas R. Keene;Marjolijn Renard;Julie De Backer

  • Role of Transforming Growth Factor-β1 and its Latent Form Binding Protein in Pseudoexfoliation Syndrome ☆

    Ursula Schlötzer-Schrehardt;Matthias Zenkel;Michael Küchle;Lynn Y. Sakai

  • Fibrillin-1: organization in microfibrils and structural properties.

    Dieter P. Reinhardt;Douglas R. Keene;Glen M. Corson;Ernst Pöschl

Frequent Co-Authors

Douglas R. Keene
Douglas R. Keene Shriners Hospitals for Children - Portland
Hans Peter Bächinger
Hans Peter Bächinger Oregon Health & Science University
Dieter P. Reinhardt
Dieter P. Reinhardt McGill University
Francesco Ramirez
Francesco Ramirez Icahn School of Medicine at Mount Sinai
Harry C. Dietz
Harry C. Dietz Johns Hopkins University School of Medicine
Robert E. Burgeson
Robert E. Burgeson Harvard University
Daniel B. Rifkin
Daniel B. Rifkin New York University
Takako Sasaki
Takako Sasaki Oita University
William A. Horton
William A. Horton Shriners Hospitals for Children - Erie
Reed E. Pyeritz
Reed E. Pyeritz University of Pennsylvania

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