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Biology and Biochemistry

D-Index
106
Citations
34832
World Ranking
1162
National Ranking
689

Overview

Douglas R. Keene is affiliated with Shriners Hospitals for Children - Portland in the United States. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with significant focus on connective tissue disorders and related cellular biology.

The scientist has contributed extensively to the fields of genetics, cell biology, surgery, orthopedics and sports medicine, and immunology and allergy. Their core research topics include connective tissue disorders, cell adhesion molecules, tendon structure and treatment, skin and cellular biology, shoulder injury and treatment, protease and inhibitor mechanisms, and autoimmune bullous skin diseases.

Among recent publications authored or co-authored by Douglas R. Keene are the following:

  • In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial, 2022, Nature Medicine
  • Tgfβ signaling is critical for maintenance of the tendon cell fate, 2020, eLife
  • QR-313, an Antisense Oligonucleotide, Shows Therapeutic Efficacy for Treatment of Dominant and Recessive Dystrophic Epidermolysis Bullosa: A Preclinical Study, 2020, Journal of Investigative Dermatology
  • Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER, 2021, Journal of Biological Chemistry
  • Reticulocalbin 3 is involved in postnatal tendon development by regulating collagen fibrillogenesis and cellular maturation, 2021, Scientific Reports

Douglas R. Keene has collaborated frequently with several researchers, including Sara F. Tufa (31 publications), Ronen Schweitzer (7 publications), David M. Hudson (5 publications), Brian A. Pryce (4 publications), and Gerhard Sengle (4 publications).

The scientist's work appears most often in the following publication venues:

  • Journal of Investigative Dermatology (5 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Microscopy and Microanalysis (4 publications)
  • Journal of Biological Chemistry (3 publications)
  • Matrix Biology (3 publications)

Best Publications

  • Type 2 alveolar cells are stem cells in adult lung

    Christina E. Barkauskas;Michael J. Cronce;Craig R. Rackley;Emily J. Bowie

  • Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.

    Lynn Y. Sakai;Douglas R. Keene;Eva Engvall

  • Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments.

    P Rousselle;G P Lunstrum;D R Keene;R E Burgeson

  • Type VII collagen is a major structural component of anchoring fibrils.

    L Y Sakai;D R Keene;N P Morris;R E Burgeson

  • Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons

    Nicholas D. Murchison;Brian A. Price;David A. Conner;Douglas R. Keene

  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.

    Thorleif Møller;Thomas Franch;Peter Højrup;Douglas R Keene

  • Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

    Zenzo Isogai;Robert N. Ono;Shin Ushiro;Douglas R. Keene

  • Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

    Daniel P. Judge;Nancy J. Biery;Douglas R. Keene;Jessica Geubtner

  • Type VII collagen forms an extended network of anchoring fibrils.

    D R Keene;L Y Sakai;G P Lunstrum;N P Morris

  • LACK OF COLLAGEN XVIII/ENDOSTATIN RESULTS IN EYE ABNORMALITIES

    Naomi Fukai;Lauri Eklund;Alexander G. Marneros;Suk Paul Oh

  • Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome.

    Lygia Pereira;Konstantinos Andrikopoulos;Konstantinos Andrikopoulos;Jenny Tian;Sui Ying Lee

  • Type VI Collagen Anchors Endothelial Basement Membranes by Interacting with Type IV Collagen

    Huey Ju Kuo;Cheryl L. Maslen;Douglas R. Keene;Robert W. Glanville

  • Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa

    John E Wagner;Akemi Ishida-Yamamoto;John A McGrath;Maria Hordinsky

  • Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals

    Toru Maeda;Tomoya Sakabe;Ataru Sunaga;Keiko Sakai

  • Type III collagen can be present on banded collagen fibrils regardless of fibril diameter.

    D R Keene;L Y Sakai;H P Bächinger;R E Burgeson

  • Cellular origin of the dermal-epidermal basement membrane

    M P Marinkovich;D R Keene;C S Rimberg;R E Burgeson

  • Type IIA Procollagen Containing the Cysteine-rich Amino Propeptide Is Deposited in the Extracellular Matrix of Prechondrogenic Tissue and Binds to TGF-β1 and BMP-2

    Yong Zhu;Anush Oganesian;Douglas R. Keene;Linda J. Sandell

  • Stable nonviral genetic correction of inherited human skin disease

    Susana Ortiz-Urda;Bhaskar Thyagarajan;Douglas R. Keene;Qun Lin

  • Laminin 5 Binds the NC-1 Domain of Type VII Collagen

    Patricia Rousselle;Douglas R. Keene;Florence Ruggiero;Marie-France Champliaud

  • Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment.

    Marie-France Champliaud;Gregory P. Lunstrum;Patricia Rousselle;Toshio Nishiyama

Frequent Co-Authors

Lynn Y. Sakai
Lynn Y. Sakai Oregon Health & Science University
Hans Peter Bächinger
Hans Peter Bächinger Oregon Health & Science University
David T. Woodley
David T. Woodley University of Southern California
Mei Chen
Mei Chen University of Southern California
M. Peter Marinkovich
M. Peter Marinkovich Stanford University
Jakub Tolar
Jakub Tolar University of Minnesota
Robert E. Burgeson
Robert E. Burgeson Harvard University
William A. Horton
William A. Horton Shriners Hospitals for Children - Erie
John A. McGrath
John A. McGrath King's College London
John E. Wagner
John E. Wagner University of Minnesota

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