Douglas R. Keene spends much of his time researching Cell biology, Fibrillin, Biochemistry, Molecular biology and Basement membrane. The concepts of his Cell biology study are interwoven with issues in Base pair, Connective tissue, Cellular differentiation and Anatomy. His research on Fibrillin focuses in particular on Fibrillin Microfibrils.
Epitope, Anchoring fibrils, Binding site and Ligand is closely connected to Biophysics in his research, which is encompassed under the umbrella topic of Biochemistry. His research integrates issues of Extracellular matrix, Integrin, Polyclonal antibodies and Immunoelectron microscopy in his study of Molecular biology. His Basement membrane research incorporates themes from Dermoepidermal junction, Collagen, type I, alpha 1 and Laminin, Type IV collagen, Lamina lucida.
The scientist’s investigation covers issues in Cell biology, Molecular biology, Extracellular matrix, Pathology and Biochemistry. His biological study spans a wide range of topics, including Tendon and Anatomy. Douglas R. Keene has researched Molecular biology in several fields, including Collagen, type I, alpha 1, Type I collagen, Basement membrane, Immunoelectron microscopy and Genetically modified mouse.
His Extracellular matrix study integrates concerns from other disciplines, such as Extracellular, Transforming growth factor beta, Matrix and Cartilage. Douglas R. Keene has included themes like Epitope and Biophysics in his Biochemistry study. In general Fibrillin study, his work on Fibrillin-2 often relates to the realm of Microfibril, thereby connecting several areas of interest.
Douglas R. Keene mainly investigates Cell biology, Tendon, Recessive dystrophic epidermolysis bullosa, Pathology and Tendon cell. His Mesenchymal stem cell and Extracellular matrix investigations are all subjects of Cell biology research. His study in Tendon is interdisciplinary in nature, drawing from both Type I collagen, Progenitor cell, Connective tissue, Function and Electron microscope.
His work carried out in the field of Recessive dystrophic epidermolysis bullosa brings together such families of science as Molecular biology and Revertant. His studies deal with areas such as Type VII collagen, Human skin and Equivalent as well as Molecular biology. His Pathology research incorporates elements of Nonsense mutation, Protein replacement therapy and Methylprednisolone.
Douglas R. Keene mainly focuses on Cell biology, Cellular differentiation, Gene, Receptor and Cell fate determination. The study incorporates disciplines such as Bacterial adhesin, Peptide sequence and Binding site in addition to Cell biology. His Cellular differentiation research includes elements of Process, Cell culture, Bone tissue and Calcification.
His study in Fibrillin Microfibrils, Fibrillins, Fibrillin and Exon falls within the category of Gene. His Receptor research is multidisciplinary, incorporating elements of Progenitor, Tendon cell, Beta, Transforming growth factor and Scleraxis. His Cell fate determination research is multidisciplinary, incorporating perspectives in TGF beta signaling pathway and Developmental biology.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.
Lynn Y. Sakai;Douglas R. Keene;Eva Engvall.
Journal of Cell Biology (1986)
Type 2 alveolar cells are stem cells in adult lung
Christina E. Barkauskas;Michael J. Cronce;Craig R. Rackley;Emily J. Bowie.
Journal of Clinical Investigation (2013)
Type VII collagen is a major structural component of anchoring fibrils.
L Y Sakai;D R Keene;N P Morris;R E Burgeson.
Journal of Cell Biology (1986)
Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.
Thorleif Møller;Thomas Franch;Peter Højrup;Douglas R Keene.
Molecular Cell (2002)
Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons
Nicholas D. Murchison;Brian A. Price;David A. Conner;Douglas R. Keene.
Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein
Zenzo Isogai;Robert N. Ono;Shin Ushiro;Douglas R. Keene.
Journal of Biological Chemistry (2003)
Type VII collagen forms an extended network of anchoring fibrils.
D R Keene;L Y Sakai;G P Lunstrum;N P Morris.
Journal of Cell Biology (1987)
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome
Daniel P. Judge;Nancy J. Biery;Douglas R. Keene;Jessica Geubtner.
Journal of Clinical Investigation (2004)
Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome.
Lygia Pereira;Lygia Pereira;Konstantinos Andrikopoulos;Konstantinos Andrikopoulos;Jenny Tian;Sui Ying Lee.
Nature Genetics (1997)
Type VI Collagen Anchors Endothelial Basement Membranes by Interacting with Type IV Collagen
Huey Ju Kuo;Cheryl L. Maslen;Douglas R. Keene;Robert W. Glanville.
Journal of Biological Chemistry (1997)
Profile was last updated on December 6th, 2021.
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