D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 83 Citations 24,313 185 World Ranking 1493 National Ranking 878

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Biochemistry

Douglas R. Keene spends much of his time researching Cell biology, Fibrillin, Biochemistry, Molecular biology and Basement membrane. The concepts of his Cell biology study are interwoven with issues in Base pair, Connective tissue, Cellular differentiation and Anatomy. His research on Fibrillin focuses in particular on Fibrillin Microfibrils.

Epitope, Anchoring fibrils, Binding site and Ligand is closely connected to Biophysics in his research, which is encompassed under the umbrella topic of Biochemistry. His research integrates issues of Extracellular matrix, Integrin, Polyclonal antibodies and Immunoelectron microscopy in his study of Molecular biology. His Basement membrane research incorporates themes from Dermoepidermal junction, Collagen, type I, alpha 1 and Laminin, Type IV collagen, Lamina lucida.

His most cited work include:

  • Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. (934 citations)
  • Type 2 alveolar cells are stem cells in adult lung (770 citations)
  • Type VII collagen is a major structural component of anchoring fibrils. (471 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Cell biology, Molecular biology, Extracellular matrix, Pathology and Biochemistry. His biological study spans a wide range of topics, including Tendon and Anatomy. Douglas R. Keene has researched Molecular biology in several fields, including Collagen, type I, alpha 1, Type I collagen, Basement membrane, Immunoelectron microscopy and Genetically modified mouse.

His Extracellular matrix study integrates concerns from other disciplines, such as Extracellular, Transforming growth factor beta, Matrix and Cartilage. Douglas R. Keene has included themes like Epitope and Biophysics in his Biochemistry study. In general Fibrillin study, his work on Fibrillin-2 often relates to the realm of Microfibril, thereby connecting several areas of interest.

He most often published in these fields:

  • Cell biology (31.70%)
  • Molecular biology (26.42%)
  • Extracellular matrix (21.51%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cell biology (31.70%)
  • Tendon (10.94%)
  • Recessive dystrophic epidermolysis bullosa (6.79%)

In recent papers he was focusing on the following fields of study:

Douglas R. Keene mainly investigates Cell biology, Tendon, Recessive dystrophic epidermolysis bullosa, Pathology and Tendon cell. His Mesenchymal stem cell and Extracellular matrix investigations are all subjects of Cell biology research. His study in Tendon is interdisciplinary in nature, drawing from both Type I collagen, Progenitor cell, Connective tissue, Function and Electron microscope.

His work carried out in the field of Recessive dystrophic epidermolysis bullosa brings together such families of science as Molecular biology and Revertant. His studies deal with areas such as Type VII collagen, Human skin and Equivalent as well as Molecular biology. His Pathology research incorporates elements of Nonsense mutation, Protein replacement therapy and Methylprednisolone.

Between 2017 and 2021, his most popular works were:

  • Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization (35 citations)
  • Type III Collagen Affects Dermal and Vascular Collagen Fibrillogenesis and Tissue Integrity in a Mutant Col3a1 Transgenic Mouse Model (26 citations)
  • Phase 1/2a clinical trial of gene-corrected autologous cell therapy for recessive dystrophic epidermolysis bullosa (25 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Genetics

Douglas R. Keene mainly focuses on Cell biology, Cellular differentiation, Gene, Receptor and Cell fate determination. The study incorporates disciplines such as Bacterial adhesin, Peptide sequence and Binding site in addition to Cell biology. His Cellular differentiation research includes elements of Process, Cell culture, Bone tissue and Calcification.

His study in Fibrillin Microfibrils, Fibrillins, Fibrillin and Exon falls within the category of Gene. His Receptor research is multidisciplinary, incorporating elements of Progenitor, Tendon cell, Beta, Transforming growth factor and Scleraxis. His Cell fate determination research is multidisciplinary, incorporating perspectives in TGF beta signaling pathway and Developmental biology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils.

Lynn Y. Sakai;Douglas R. Keene;Eva Engvall.
Journal of Cell Biology (1986)

1489 Citations

Type 2 alveolar cells are stem cells in adult lung

Christina E. Barkauskas;Michael J. Cronce;Craig R. Rackley;Emily J. Bowie.
Journal of Clinical Investigation (2013)

910 Citations

Type VII collagen is a major structural component of anchoring fibrils.

L Y Sakai;D R Keene;N P Morris;R E Burgeson.
Journal of Cell Biology (1986)

725 Citations

Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction.

Thorleif Møller;Thomas Franch;Peter Højrup;Douglas R Keene.
Molecular Cell (2002)

692 Citations

Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons

Nicholas D. Murchison;Brian A. Price;David A. Conner;Douglas R. Keene.
Development (2007)

607 Citations

Latent Transforming Growth Factor β-binding Protein 1 Interacts with Fibrillin and Is a Microfibril-associated Protein

Zenzo Isogai;Robert N. Ono;Shin Ushiro;Douglas R. Keene.
Journal of Biological Chemistry (2003)

561 Citations

Type VII collagen forms an extended network of anchoring fibrils.

D R Keene;L Y Sakai;G P Lunstrum;N P Morris.
Journal of Cell Biology (1987)

505 Citations

Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome

Daniel P. Judge;Nancy J. Biery;Douglas R. Keene;Jessica Geubtner.
Journal of Clinical Investigation (2004)

472 Citations

Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome.

Lygia Pereira;Lygia Pereira;Konstantinos Andrikopoulos;Konstantinos Andrikopoulos;Jenny Tian;Sui Ying Lee.
Nature Genetics (1997)

440 Citations

Type VI Collagen Anchors Endothelial Basement Membranes by Interacting with Type IV Collagen

Huey Ju Kuo;Cheryl L. Maslen;Douglas R. Keene;Robert W. Glanville.
Journal of Biological Chemistry (1997)

371 Citations

Best Scientists Citing Douglas R. Keene

Harry C. Dietz

Harry C. Dietz

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Jouni Uitto

Jouni Uitto

Thomas Jefferson University

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Leena Bruckner-Tuderman

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Cay M. Kielty

Cay M. Kielty

Wellcome Centre for Cell-Matrix Research

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Lynn Y. Sakai

Lynn Y. Sakai

Oregon Health & Science University

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John A. McGrath

John A. McGrath

King's College London

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Detlef Zillikens

Detlef Zillikens

University of Lübeck

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Dieter P. Reinhardt

Dieter P. Reinhardt

McGill University

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Francesco Ramirez

Francesco Ramirez

Icahn School of Medicine at Mount Sinai

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M. Peter Marinkovich

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Stanford University

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Robert P. Mecham

Robert P. Mecham

Washington University in St. Louis

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Harvard University

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Manuel Koch

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David T. Woodley

David T. Woodley

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Hans Peter Bächinger

Hans Peter Bächinger

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David E. Birk

David E. Birk

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Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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