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Biology and Biochemistry

D-Index
73
Citations
19463
World Ranking
5923
National Ranking
2803

Overview

Jakub Tolar is affiliated with the University of Minnesota in the United States. Their work spans across biochemistry, genetics, molecular biology, and medicine, reflecting a broad interdisciplinary research approach.

Tolar's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader areas, their research focuses on several subfields such as:

  • Molecular Biology
  • Cell Biology
  • Genetics
  • Immunology
  • Pathology and Forensic Medicine

Their primary topics of research encompass:

  • Skin and Cellular Biology Research
  • CRISPR and Genetic Engineering
  • Autoimmune Bullous Skin Diseases
  • Virus-based gene therapy research
  • Hematopoietic Stem Cell Transplantation
  • Pluripotent Stem Cells Research
  • Cellular Mechanics and Interactions

Jakub Tolar has contributed to various scientific publications, frequently publishing in venues such as:

  • Blood
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • British Journal of Dermatology
  • Journal of Investigative Dermatology
  • Cytotherapy

Among recent papers associated with their work are:

  • Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial (2020, The Lancet)
  • Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity (2022, Nature Biotechnology)
  • Phage-assisted evolution and protein engineering yield compact, efficient prime editors (2023, Cell)
  • The Minnesota mobile extracorporeal cardiopulmonary resuscitation consortium for treatment of out-of-hospital refractory ventricular fibrillation: Program description, performance, and outcomes (2020, EClinicalMedicine)
  • Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing (2024, Nature Biomedical Engineering)

Their frequent collaborators include Cindy Eide, Megan Riddle, Christen L. Ebens, Mark J. Osborn, and Bruce R. Blazar, with multiple co-authored publications demonstrating ongoing collaborative research efforts.

Best Publications

  • Sarcoma derived from cultured mesenchymal stem cells

    Jakub Tolar;Alma J. Nauta;Mark J. Osborn;Angela Panoskaltsis Mortari

  • Advanced reperfusion strategies for patients with out-of-hospital cardiac arrest and refractory ventricular fibrillation (ARREST): a phase 2, single centre, open-label, randomised controlled trial.

    Demetris Yannopoulos;Jason Bartos;Ganesh Raveendran;Emily Walser

  • Mechanisms of disease osteopetrosis

    Jakub Tolar;Steven L. Teitelbaum;Paul J. Orchard

  • Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.

    Steven L. Highfill;Paulo C. Rodriguez;Qing Zhou;Christine A. Goetz

  • Concise review: hitting the right spot with mesenchymal stromal cells.

    Jakub Tolar;Katarina Le Blanc;Armand Keating;Bruce R. Blazar

  • Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa

    John E Wagner;Akemi Ishida-Yamamoto;John A McGrath;Maria Hordinsky

  • The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro

    Jesse H. Arbuckle;Maria M. Medveczky;Janos Luka;Stephen H. Hadley

  • IL15 Trispecific Killer Engagers (TriKE) Make Natural Killer Cells Specific to CD33+ Targets While Also Inducing Persistence, In Vivo Expansion, and Enhanced Function

    Daniel A. Vallera;Martin Felices;Ron McElmurry;Valarie McCullar

  • Marked increased risk of Epstein-Barr virus-related complications with the addition of antithymocyte globulin to a nonmyeloablative conditioning prior to unrelated umbilical cord blood transplantation

    Claudio G. Brunstein;Daniel J. Weisdorf;Todd DeFor;Juliet N. Barker

  • Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft.

    John E Wagner;Claudio G Brunstein;Anthony E. Boitano;Todd E. DeFor

  • Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation : an international multicenter study

    Mieke Aldenhoven;Robert F. Wynn;Paul J. Orchard;Anne O'Meara

  • Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

    Qing Zhou;Meghan E. Munger;Steven L. Highfill;Jakub Tolar

  • TALEN-based Gene Correction for Epidermolysis Bullosa

    Mark J Osborn;Colby G Starker;Amber N McElroy;Beau R Webber

  • Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report.

    Weston P. Miller;Steven M. Rothman;David Nascene;Teresa Kivisto

  • Germline Mutations in BRCA2: Shared Genetic Susceptibility to Breast Cancer, Early Onset Leukemia and Fanconi Anemia

    John E. Wagner;Jakub Tolar;Orna Levran;Thomas Scholl

  • Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

    Martin Felices;Alexander J. Lenvik;Ron McElmurry;Sami Chu

  • Incorporation of Immune Checkpoint Blockade into Chimeric Antigen Receptor T Cells (CAR-Ts): Combination or Built-In CAR-T

    Dok Hyun H Yoon;Mark J Osborn;Jakub Tolar;Chong Jai Kim

  • Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

    Mark J. Osborn;Beau R. Webber;Friederike Knipping;Cara Lin Lonetree

  • 3D Printed Functional and Biological Materials on Moving Freeform Surfaces.

    Zhijie Zhu;Shuang Zhuang Guo;Tessa Hirdler;Cindy Eide

  • Optimization of conditioning for marrow transplantation from unrelated donors for patients with aplastic anemia after failure of immunosuppressive therapy

    H. Joachim Deeg;Margaret O'Donnell;Jakub Tolar;Rajni Agarwal

Frequent Co-Authors

Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Paul J. Orchard
Paul J. Orchard University of Minnesota
John E. Wagner
John E. Wagner University of Minnesota
Angela Panoskaltsis-Mortari
Angela Panoskaltsis-Mortari University of Minnesota
John A. McGrath
John A. McGrath King's College London
Todd E. DeFor
Todd E. DeFor University of Minnesota
Douglas R. Keene
Douglas R. Keene Shriners Hospitals for Children - Portland
Jeffrey S. Miller
Jeffrey S. Miller University of Minnesota
R. Scott McIvor
R. Scott McIvor University of Minnesota

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