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Biology and Biochemistry

D-Index
64
Citations
20172
World Ranking
9486
National Ranking
4184

Overview

Paul J. Orchard is affiliated with the University of Minnesota in the United States and has an extensive publication record across the fields of medicine and biochemistry, genetics, and molecular biology. Their work includes contributions to both broad and specialized subfields such as molecular biology, physiology, genetics, hematology, and clinical biochemistry.

The main research topics covered by Orchard include peroxisome proliferator-activated receptors, lysosomal storage disorders research, metabolism and genetic disorders, hematopoietic stem cell transplantation, acute lymphoblastic leukemia research, neuroinflammation and neurodegeneration mechanisms, as well as glycogen storage diseases and myoclonus.

Orchard's frequent publication venues reflect a strong focus on genetic and metabolic disorders as well as transplantation biology. These venues include Molecular Genetics and Metabolism, Transplantation and Cellular Therapy, Biology of Blood and Marrow Transplantation, Blood, and Journal of Inherited Metabolic Disease.

The scientist has collaborated with various co-authors notable in their fields, including Troy C. Lund, Ashish O. Gupta, Julie B. Eisengart, Nishitha R. Pillai, and David Nascene. These collaborations cover a significant number of joint publications, indicating ongoing research partnerships.

Recent papers authored or co-authored by Paul J. Orchard include:

  • Indications for Hematopoietic Cell Transplantation and Immune Effector Cell Therapy: Guidelines from the American Society for Transplantation and Cellular Therapy, 2020, Biology of Blood and Marrow Transplantation
  • International Recommendations for the Diagnosis and Management of Patients With Adrenoleukodystrophy, 2022, Neurology
  • Mucopolysaccharidosis Type I: A Review of the Natural History and Molecular Pathology, 2020, Cells
  • Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy, 2024, New England Journal of Medicine
  • Mucopolysaccharidosis Type I: Current Treatments, Limitations, and Prospects for Improvement, 2021, Biomolecules

Best Publications

  • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta

    Edwin M. Horwitz;Darwin J. Prockop;Lorraine A. Fitzpatrick;Winston W. K. Koo

  • Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.

    Jeffrey S. Miller;Yvette Soignier;Angela Panoskaltsis-Mortari;Sarah A. McNearney

  • Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survival.

    John E. Wagner;Juliet N. Barker;Todd E. DeFor;K. Scott Baker

  • Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis.

    Annalisa Frattini;Paul J. Orchard;Cristina Sobacchi;Silvia Giliani

  • Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta

    Edwin M. Horwitz;Darwin J. Prockop;Patricia L. Gordon;Winston W. K. Koo

  • Mechanisms of disease osteopetrosis

    Jakub Tolar;Steven L. Teitelbaum;Paul J. Orchard

  • Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy

    Florian Eichler;Christine Duncan;Patricia L. Musolino;Paul J. Orchard

  • Indications for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation

    Navneet S. Majhail;Stephanie H. Farnia;Paul A. Carpenter;Richard E. Champlin

  • Cerebral X-linked adrenoleukodystrophy: the international hematopoietic cell transplantation experience from 1982 to 1999.

    Charles Peters;Lawrence R. Charnas;Ye Tan;Richard S. Ziegler

  • Long-term outcome of Hurler syndrome patients after hematopoietic cell transplantation : an international multicenter study

    Mieke Aldenhoven;Robert F. Wynn;Paul J. Orchard;Anne O'Meara

  • Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

    Matteo M. Guerrini;Cristina Sobacchi;Barbara Cassani;Mario Abinun

  • Outcomes after allogeneic hematopoietic cell transplantation for childhood cerebral adrenoleukodystrophy: the largest single-institution cohort report.

    Weston P. Miller;Steven M. Rothman;David Nascene;Teresa Kivisto

  • Chloride Channel ClCN7 Mutations Are Responsible for Severe Recessive, Dominant, and Intermediate Osteopetrosis

    Annalisa Frattini;Alessandra Pangrazio;Lucia Susani;Cristina Sobacchi

  • The mutational spectrum of human malignant autosomal recessive osteopetrosis

    Cristina Sobacchi;Annalisa Frattini;Paul J Orchard;Oscar Porras

  • Long-Term Results of Autologous Stem Cell Transplantation for Primary Refractory or Relapsed Hodgkin’s Lymphoma

    Navneet S. Majhail;Daniel J. Weisdorf;Todd E. Defor;Jeffrey S. Miller

  • Treatment of haemangioendotheliomas with alpha interferon.

    Paul J Orchard;Clark M. Smith;William G. Woods;Deborah L. Day

  • Diagnosis and Management of Osteopetrosis: Consensus Guidelines From the Osteopetrosis Working Group.

    Calvin C Wu;Michael J Econs;Linda A DiMeglio;Karl L Insogna

  • Outcomes of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning

    Jaap Jan Boelens;Mieke Aldenhoven;Duncan Purtill;Annalisa Ruggeri

  • Indications for Hematopoietic Cell Transplantation and Immune Effector Cell Therapy: Guidelines from the American Society for Transplantation and Cellular Therapy.

    Abraham S. Kanate;Navneet S. Majhail;Bipin N. Savani;Christopher Bredeson

  • Disease-specific hematopoietic cell transplantation: nonmyeloablative conditioning regimen for dyskeratosis congenita

    A. C. Dietz;Paul J Orchard;K. S. Baker;R. H. Giller

Frequent Co-Authors

Jakub Tolar
Jakub Tolar University of Minnesota
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
John E. Wagner
John E. Wagner University of Minnesota
Todd E. DeFor
Todd E. DeFor University of Minnesota
Daniel J. Weisdorf
Daniel J. Weisdorf University of Minnesota
Joanne Kurtzberg
Joanne Kurtzberg Duke University
Jeffrey S. Miller
Jeffrey S. Miller University of Minnesota
Stella M. Davies
Stella M. Davies Cincinnati Children's Hospital Medical Center
Paul Veys
Paul Veys Great Ormond Street Hospital
R. Scott McIvor
R. Scott McIvor University of Minnesota

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