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Molecular Biology
Italy
2025

D-Index & Metrics

Genetics

D-Index
88
Citations
34527
World Ranking
1154
National Ranking
13

Molecular Biology

D-Index
88
Citations
34527
World Ranking
776
National Ranking
11

Research.com Recognitions

  • 2025 - Research.com Molecular Biology in Italy Leader Award
  • 2010 - Fellow, The World Academy of Sciences

Overview

Francisco E. Baralle is affiliated with the International Centre for Genetic Engineering and Biotechnology in Italy. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a particular emphasis on Molecular Biology.

Their work covers several specialized subfields including Molecular Biology, Surgery, Neurology, Transplantation, and Biochemistry. Research themes are centered on RNA Research and Splicing, RNA modifications and cancer, Organ Transplantation Techniques and Outcomes, Renal Transplantation Outcomes and Treatments, Transplantation: Methods and Outcomes, Nuclear Structure and Function, and Lipid metabolism and biosynthesis.

Frequent coauthors collaborating with Francisco E. Baralle include:

  • Marco Baralle
  • Laura De Conti
  • Pablo J. Giraudi
  • Gabriel Gondolesi
  • Claudio Tiribelli

Publications by Francisco E. Baralle have appeared in various scientific venues. They have published multiple papers in the following journals:

  • Annals of Hepatology
  • Experimental & Molecular Medicine
  • Disease Models & Mechanisms
  • Neurobiology of Disease
  • Molecular Medicine

Some recent notable papers include:

  • Alternative splicing and liver disease, 2021, Annals of Hepatology
  • Physiological tissue-specific and age-related reduction of mouse TDP-43 levels is regulated by epigenetic modifications, 2022, Disease Models & Mechanisms
  • Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance, 2021, Neurobiology of Disease
  • Tailored antisense oligonucleotides designed to correct aberrant splicing reveal actionable groups of mutations for rare genetic disorders, 2024, Experimental & Molecular Medicine
  • OTC intron 4 variations mediate pathogenic splicing patterns caused by the c.386G>A mutation in humans and spfash mice, and govern susceptibility to RNA-based therapies, 2021, Molecular Medicine

Francisco E. Baralle was awarded the title of Fellow of The World Academy of Sciences in 2010.

Best Publications

  • TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

    Jemeen Sreedharan;Ian P. Blair;Vineeta B. Tripathi;Xun Hu

  • The structure and evolution of the human β-globin gene family

    Argiris Efstratiadis;James W. Posakony;Tom Maniatis;Richard M. Lawn

  • Alternative splicing as a regulator of development and tissue identity

    Francisco E. Baralle;Jimena Giudice

  • Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.

    A.R. Kornblihtt;K. Umezawa;K. Vibe-Pedersen;F.E. Baralle

  • Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

    Masato Hasegawa;Tetsuaki Arai;Takashi Nonaka;Fuyuki Kametani

  • Characterization and functional implications of the RNA binding properties of nuclear factor TDP-43, a novel splicing regulator of CFTR exon 9.

    Emanuele Buratti;Francisco E. Baralle

  • Nuclear factor TDP‐43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

    Emanuele Buratti;Thilo Dörk;Elisabetta Zuccato;Franco Pagani

  • Structural determinants of the cellular localization and shuttling of TDP-43

    Youhna M. Ayala;Paola Zago;Andrea D'Ambrogio;Ya Fei Xu

  • Genomic variants in exons and introns: identifying the splicing spoilers

    Franco Pagani;Francisco E Baralle

  • Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity

    Yong Jie Zhang;Ya Fei Xu;Casey Cook;Tania F. Gendron

  • TDP-43 regulates its mRNA levels through a negative feedback loop

    Youhna M Ayala;Laura De Conti;S Eréndira Avendaño-Vázquez;Ashish Dhir

  • TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

    Emanuele Buratti;Antonia Brindisi;Maurizio Giombi;Sergio G. Tisminetzky

  • Multiple roles of TDP-43 in gene expression, splicing regulation, and human disease

    Emanuele Buratti;Francisco E Baralle

  • Influence of RNA Secondary Structure on the Pre-mRNA Splicing Process

    Emanuele Buratti;Francisco E. Baralle

  • Functional association between promoter structure and transcript alternative splicing

    Cramer P;Pesce Cg;Baralle Fe;Kornblihtt Ar

  • Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon.

    L. Zardi;B. Carnemolla;A. Siri;T. E. Petersen

  • Progranulin Mediates Caspase-Dependent Cleavage of TAR DNA Binding Protein-43

    Yong Jie Zhang;Ya Fei Xu;Chad A. Dickey;Emanuele Buratti

  • Human, Drosophila, and C.elegans TDP43: nucleic acid binding properties and splicing regulatory function.

    Youhna M. Ayala;Sergio Pantano;Andrea D'Ambrogio;Emanuele Buratti

  • Coupling of Transcription with Alternative Splicing: RNA Pol II Promoters Modulate SF2/ASF and 9G8 Effects on an Exonic Splicing Enhancer

    Paula Cramer;Javier F Cáceres;Demián Cazalla;Sebastián Kadener

  • Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan

    Andrés F. Muro;Anil K. Chauhan;Srecko Gajovic;Alessandra Iaconcig

Frequent Co-Authors

Emanuele Buratti
Emanuele Buratti International Centre for Genetic Engineering and Biotechnology
Alberto R. Kornblihtt
Alberto R. Kornblihtt University of Buenos Aires
Giorgio Casari
Giorgio Casari Vita-Salute San Raffaele University
Renu Tuteja
Renu Tuteja International Centre for Genetic Engineering and Biotechnology
Antonio Pizzuti
Antonio Pizzuti Sapienza University of Rome
Masato Hasegawa
Masato Hasegawa Tokyo Metropolitan Institute of Medical Science
Takashi Nonaka
Takashi Nonaka Tokyo Metropolitan Institute of Medical Science
Giuseppe Borsani
Giuseppe Borsani University of Brescia
Elizabeth M. C. Fisher
Elizabeth M. C. Fisher University College London
Vincent Plagnol
Vincent Plagnol University College London

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