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Medicine

D-Index
115
Citations
67657
World Ranking
4453
National Ranking
173

Overview

Ian R. Mackenzie is affiliated with the University of British Columbia in Canada. Their research primarily spans the field of medicine, with a focus on neurology, physiology, psychiatry and mental health, molecular biology, and genetics.

The scientist has contributed extensively to topics including:

  • Amyotrophic Lateral Sclerosis Research
  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Dementia and Cognitive Impairment Research
  • Neurological diseases and metabolism
  • Prion Diseases and Protein Misfolding
  • Neurogenetic and Muscular Disorders Research

Mackenzie has been published frequently in several scientific venues, notably:

  • Alzheimer s & Dementia (52 publications)
  • Acta Neuropathologica (10 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (8 publications)
  • Neurology (4 publications)
  • Acta Neuropathologica Communications (4 publications)

Selected recent papers authored or co-authored by Mackenzie include:

  • "LATE-NC staging in routine neuropathologic diagnosis: an update," 2022, Acta Neuropathologica
  • "Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium," 2020, Alzheimer s & Dementia
  • "Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases," 2022, Cell
  • "Temporal order of clinical and biomarker changes in familial frontotemporal dementia," 2022, Nature Medicine
  • "Frontotemporal Lobar Degeneration TDP-43-Immunoreactive Pathological Subtypes: Clinical and Mechanistic Significance," 2021, Advances in experimental medicine and biology

The scientist has frequently collaborated with several researchers, including:

  • Ging-Yuek Robin Hsiung (74 collaborations)
  • Bradley F. Boeve (49 collaborations)
  • Hilary W. Heuer (46 collaborations)
  • Adam L. Boxer (45 collaborations)
  • Leah K. Forsberg (44 collaborations)

Best Publications

  • Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

    Manuela Neumann;Deepak M. Sampathu;Linda K. Kwong;Adam C. Truax

  • Inflammation and Alzheimer's disease.

    H Akiyama;S Barger;S Barnum;B Bradt

  • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

    Mariely DeJesus-Hernandez;Ian R. Mackenzie;Bradley F. Boeve;Adam L. Boxer

  • Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

    Matt Baker;Ian R. Mackenzie;Stuart M. Pickering-Brown;Jennifer Gass

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Primary age-related tauopathy (PART): a common pathology associated with human aging

    John F. Crary;John Q. Trojanowski;Julie A. Schneider;Jose F. Abisambra

  • Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration

    Nigel J. Cairns;Eileen H. Bigio;Ian R A Mackenzie;Manuela Neumann

  • Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

    Ian R.A. Mackenzie;Eileen H. Bigio;Paul G. Ince;Felix Geser

  • Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update

    Ian R. A. Mackenzie;Manuela Neumann;Eileen H. Bigio;Nigel J. Cairns

  • A harmonized classification system for FTLD-TDP pathology

    Ian R. A. Mackenzie;Manuela Neumann;Atik Baborie;Deepak M. Sampathu

  • TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

    Ian R.A. Mackenzie;Rosa Rademakers;Manuela Neumann

  • ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import

    Dorothee Dormann;Dorothee Dormann;Ramona Rodde;Ramona Rodde;Dieter Edbauer;Eva Bentmann;Eva Bentmann

  • A new subtype of frontotemporal lobar degeneration with FUS pathology.

    Manuela Neumann;Rosa Rademakers;Sigrun Roeber;Matt Baker

  • Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation.

    Hansen Lui;Jiasheng Zhang;Stefanie R. Makinson;Michelle K. Cahill

  • Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration.

    Elisabeth H. Thijssen;Elisabeth H. Thijssen;Renaud La Joie;Amy Wolf;Amelia Strom

  • Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

    Jennifer Gass;Ashley Cannon;Ian R. Mackenzie;Bradley Boeve

  • Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

    Vivianna M. Van Deerlin;Patrick M A Sleiman;Maria Martinez-Lage;Maria Martinez-Lage;Alice Chen-Plotkin

  • TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

    Ian R. Mackenzie;Alexandra M. Nicholson;Mohona Sarkar;James Messing

  • TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions.

    Nigel J. Cairns;Manuela Neumann;Manuela Neumann;Eileen H. Bigio;Ida E. Holm

  • A harmonized classification system for FTLD-TDP pathology Ian R. A. MackenzieManuela NeumannAtik BaborieDeepak M. Sampathu • Daniel Du PlessisEvelyn JarosRobert H. PerryJohn Q. Trojanowski • David M. A. MannVirginia M. Y. Lee

    I. R. A. Mackenzie;M. Neumann;A. Baborie;D. Du Plessis

Frequent Co-Authors

Rosa Rademakers
Rosa Rademakers University of Antwerp
Howard Feldman
Howard Feldman University of California, San Diego
Manuela Neumann
Manuela Neumann University of Tübingen
Bruce L. Miller
Bruce L. Miller University of California, San Francisco
Bradley F. Boeve
Bradley F. Boeve Mayo Clinic
Murray Grossman
Murray Grossman University of Pennsylvania
David S. Knopman
David S. Knopman Mayo Clinic
John Q. Trojanowski
John Q. Trojanowski University of Pennsylvania

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