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Neill R. Graff-Radford

Neill R. Graff-Radford

D-Index & Metrics

Medicine

D-Index
144
Citations
93657
World Ranking
1425
National Ranking
832

Overview

Neill R. Graff-Radford is affiliated with the Mayo Clinic in the United States and has contributed extensively to medical research, particularly in the field of neurology. Their work spans multiple areas, including Alzheimer's disease, dementia, and related neurodegenerative disorders. Over the course of their career, they have published numerous research articles and collaborated frequently with other experts in the field.

The primary fields of study associated with Graff-Radford's research include Medicine, with notable subfields such as Neurology, Physiology, Psychiatry and Mental Health, Molecular Biology, and Cognitive Neuroscience. Their research has primarily focused on complex neurological conditions and the biological mechanisms underlying these diseases.

Key topics addressed in their work are:

  • Alzheimer's disease research and treatments
  • Dementia and Cognitive Impairment Research
  • Parkinson's Disease Mechanisms and Treatments
  • Amyotrophic Lateral Sclerosis Research
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • Cerebrospinal fluid and hydrocephalus

Graff-Radford has co-authored extensively with several frequent collaborators, including Bradley F. Boeve, Gregory S. Day, Dennis W. Dickson, David S. Knopman, and David T. Jones. These collaborations reflect a strong network within the neurology research community, facilitating multidisciplinary approaches to studying neurodegenerative diseases.

Their research has been published in prominent scientific venues, including:

  • Alzheimer s & Dementia
  • Neurology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • Annals of Neurology

Several of their recent papers demonstrate the scope and impact of their research:

  • A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease (2020, Nature Medicine)
  • TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A (2022, Nature)
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020, Nature Communications)
  • APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids (2020, Nature Communications)
  • Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium (2020, Alzheimer s & Dementia)

Best Publications

  • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

    Mariely DeJesus-Hernandez;Ian R. Mackenzie;Bradley F. Boeve;Adam L. Boxer

  • Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium

    Ian G. McKeith;Bradley F. Boeve;Dennis W. DIckson;Glenda Halliday

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Genome-wide analysis of genetic loci associated with Alzheimer disease.

    Sudha Seshadri;Annette L. Fitzpatrick;M Arfan Ikram;Anita L. DeStefano

  • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

    Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging

    J. Eric Ahlskog;Yonas E. Geda;Neill R. Graff-Radford;Ronald C. Petersen

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study.

    Melissa E Murray;Neill R Graff-Radford;Owen A Ross;Ronald C Petersen

  • The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers.

    John C. Morris;Sandra Weintraub;Helena C. Chui;Jeffrey Cummings

  • The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery.

    Sandra Weintraub;David Salmon;Nathaniel Mercaldo;Steven Ferris

  • Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank.

    Warren W. Barker;Cheryl A. Luis;Alice Kashuba;Mercy Luis

  • TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease

    Catalina Amador-Ortiz;Wen Lang Lin;Zeshan Ahmed;David Personett

  • Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

    Oliver Preische;Oliver Preische;Stephanie A. Schultz;Anja Apel;Anja Apel;Jens Kuhle

  • Detecting Dementia With the Mini-Mental State Examination in Highly Educated Individuals

    Sid E. O'Bryant;Joy D. Humphreys;Glenn E. Smith;Robert J. Ivnik

  • Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy

    D. F. Tang-Wai;N. R. Graff-Radford;B. F. Boeve;D. W. Dickson

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

    Jennifer Gass;Ashley Cannon;Ian R. Mackenzie;Bradley Boeve

  • Association of Low Plasma Aβ42/Aβ40 Ratios With Increased Imminent Risk for Mild Cognitive Impairment and Alzheimer Disease

    Neill R. Graff-Radford;Julia E. Crook;John Lucas;Bradley F. Boeve

Frequent Co-Authors

Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Bradley F. Boeve
Bradley F. Boeve Mayo Clinic
David S. Knopman
David S. Knopman Mayo Clinic
Rosa Rademakers
Rosa Rademakers University of Antwerp

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