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Zbigniew K. Wszolek

Zbigniew K. Wszolek

D-Index & Metrics

Medicine

D-Index
125
Citations
67128
World Ranking
3053
National Ranking
1686

Overview

Zbigniew K. Wszolek is a researcher affiliated with the Mayo Clinic in the United States. Their work spans several interconnected fields with significant contributions primarily in medicine, biochemistry, genetics, molecular biology, and neuroscience. Within these broader areas, their subfields of focus include neurology, molecular biology, physiology, cellular and molecular neuroscience, and genetics.

Their research topics cover a range of neurological and neurodegenerative conditions and mechanisms. Key themes include Parkinson's disease mechanisms and treatments, Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, amyotrophic lateral sclerosis research, neurological diseases and metabolism, RNA regulation and disease, and genetic neurodegenerative diseases.

Zbigniew K. Wszolek has published extensively in several prominent journals. Frequent venues for their publications include Parkinsonism & Related Disorders, Neurology, Neurologia i Neurochirurgia Polska, Alzheimer's & Dementia, and Movement Disorders.

Collaborative efforts feature regular coauthors such as Dennis W. Dickson, Owen A. Ross, Jarosław Dulski, Ryan J. Uitti, and Bradley F. Boeve, with coauthorship counts ranging from 44 to 82 joint publications.

Their recent papers illustrate active engagement in contemporary neurological research:

  • "APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids," 2020, Nature Communications
  • "Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome," 2021, Nature Communications
  • "Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium," 2020, Alzheimer's & Dementia
  • "Inhibition of colony stimulating factor-1 receptor (CSF-1R) as a potential therapeutic strategy for neurodegenerative diseases: opportunities and challenges," 2022, Cellular and Molecular Life Sciences
  • "Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial," 2021, The Lancet Neurology

Best Publications

  • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

    Mariely DeJesus-Hernandez;Ian R. Mackenzie;Bradley F. Boeve;Adam L. Boxer

  • Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

    Alexander Zimprich;Alexander Zimprich;Saskia Biskup;Petra Leitner;Peter Lichtner

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

    Daniel G Healy;Mario Falchi;Sean S O'Sullivan;Vincenzo Bonifati

  • Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

    Ming Hong;Victoria Zhukareva;Vanessa Vogelsberg-Ragaglia;Zbigniew Wszolek

  • Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria.

    Dennis W Dickson;Heiko Braak;John E Duda;Charles Duyckaerts

  • Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease

    B. F. Boeve;M. H. Silber;C. B. Saper;T. J. Ferman

  • VPS35 Mutations in Parkinson Disease

    Carles Vilariño-Güell;Christian Wider;Owen A. Ross;Justus C. Dachsel

  • Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications

    Matt Farrer;Jennifer Kachergus;Lysia Forno;Sarah Lincoln

  • DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers

    C. F. Lippa;J. E. Duda;M. Grossman;H. I. Hurtig

  • Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy

    Günter U. Höglinger;Nadine M. Melhem;Dennis W. Dickson;Patrick M A Sleiman

  • Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration

    Jennifer Gass;Ashley Cannon;Ian R. Mackenzie;Bradley Boeve

  • A susceptibility locus for Parkinson's disease maps to chromosome 2p13

    Thomas Gasser;Bertram Müller-Myhsok;Zbigniew K. Wszolek;Ralph Oehlmann

  • TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

    Ian R. Mackenzie;Alexandra M. Nicholson;Mohona Sarkar;James Messing

  • Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations

    Jennifer Kachergus;Ignacio F. Mata;Mary Hulihan;Julie P. Taylor

  • Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

    Lorraine N. Clark;Parvoneh Poorkaj;Zbigniew Wszolek;Daniel H. Geschwind

  • Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

    Oliver Cooper;Hyemyung Seo;Shaida Andrabi;Cristina Guardia-Laguarta

  • Mutations in the colony stimulating factor 1 receptor ( CSF1R ) gene cause hereditary diffuse leukoencephalopathy with spheroids

    Rosa Rademakers;Matt Baker;Alexandra M Nicholson;Nicola J Rutherford

  • Accumulation of Pathological Tau Species and Memory Loss in a Conditional Model of Tauopathy

    Zdenek Berger;Hanno Roder;Amanda Hanna;Aaron Carlson

  • Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis.

    Nicola J. Rutherford;Yong-Jie Zhang;Matt Baker;Jennifer M Gass

Frequent Co-Authors

Ryan J. Uitti
Ryan J. Uitti Mayo Clinic
Owen A. Ross
Owen A. Ross Mayo Clinic
Rosa Rademakers
Rosa Rademakers University of Antwerp
Matthew J. Farrer
Matthew J. Farrer University of Florida
Bradley F. Boeve
Bradley F. Boeve Mayo Clinic
David S. Knopman
David S. Knopman Mayo Clinic
Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Kejal Kantarci
Kejal Kantarci Mayo Clinic

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