World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Medicine
UK
2026

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Best Scientists

D-Index
217
Citations
263535
World Ranking
147
National Ranking
20

Molecular Biology

D-Index
209
Citations
227953
World Ranking
15
National Ranking
1

Medicine

D-Index
220
Citations
272816
World Ranking
85
National Ranking
13

Research.com Recognitions

  • 2026 - Research.com Medicine in United Kingdom Leader Award
  • 2026 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United Kingdom Leader Award
  • 2025 - Research.com Molecular Biology in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2023 - Research.com Medicine in United Kingdom Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2018 - Member of Academia Europaea
  • 1993 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 1984 - Fellow of the American Association for the Advancement of Science (AAAS)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

John Hardy is affiliated with University College London in the United Kingdom. Their research focuses primarily on diverse fields within medicine and biology, including neurology, molecular biology, and genetics. The main topics covered in their work include Alzheimer's disease research and treatments, Parkinson's disease mechanisms and treatments, neuroinflammation and neurodegeneration mechanisms, neurological diseases and metabolism, genetic associations and epidemiology, nuclear receptors and signaling, and bioinformatics and genomic networks.

Frequent publication venues for John Hardy include bioRxiv (Cold Spring Harbor Laboratory) with 77 publications, Alzheimer's & Dementia with 23, Brain with 15, Brain Communications with 9, and npj Parkinson's Disease with 9.

They have coauthored extensively with several researchers, including Mina Ryten (83 papers), Henry Houlden (56 papers), Huw R. Morris (53 papers), Cornelis Blauwendraat (45 papers), and Regina H. Reynolds (45 papers).

Some of their recent papers include:

  • The Amyloid-β Pathway in Alzheimer's Disease, 2021, Molecular Psychiatry
  • The β-Secretase BACE1 in Alzheimer's Disease, 2020, Biological Psychiatry
  • Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology, 2021, Nature Genetics
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study, 2020, Nature Communications
  • Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel, 2020, JAMA Neurology

John Hardy's work spans multiple interconnected subfields such as neurology, molecular biology, physiology, genetics, and cellular and molecular neuroscience. Their contributions have been recognized with several awards, including the Member of Academia Europaea in 2018, the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases awarded by the American Academy of Neurology in 1993, Fellow of the American Association for the Advancement of Science (AAAS) in 1984, and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

    John Hardy;Dennis J. Selkoe

  • Alzheimer's disease: the amyloid cascade hypothesis

    John A. Hardy;Gerald A. Higgins

  • The amyloid hypothesis of Alzheimer's disease at 25 years

    Dennis J Selkoe;John Hardy

  • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

    Alison Goate;Marie-Christine Chartier-Harlin;Mike Mullan;Jeremy Brown

  • Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.

    B. Winblad;K. Palmer;Miia Kivipelto;V. Jelic

  • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium

    I. G. McKeith;I. G. McKeith;D. W. Dickson;J. Lowe;M. Emre

  • α-Synuclein Locus Triplication Causes Parkinson's Disease

    A. B. Singleton;M. Farrer;J. Johnson;A. Singleton

  • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

    Alan E. Renton;Elisa Majounie;Adrian James Waite;Javier Simón-Sánchez;Javier Simón-Sánchez

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

    M. Hutton;C. L. Lendon;P. Rizzu;M. Baker

  • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

    D. Scheuner;C. Eckman;C. Eckman;M. Jensen;X. Song

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Amyloid deposition as the central event in the aetiology of Alzheimer's disease

    John Hardy;David Allsop

  • TREM2 Variants in Alzheimer's Disease

    Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Genome-wide association study reveals genetic risk underlying Parkinson's disease

    Javier Simón-Sánchez;Claudia Schulte;Jose M Bras;Jose M Bras;Manu Sharma

  • A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease.

    Dave Morgan;David M. Diamond;Paul E. Gottschall;Kenneth E. Ugen

  • Amyloid, the presenilins and Alzheimer's disease

    John Hardy

  • SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE

    A Goate;Mc Chartierharlin;M Mullan;J Brown

Frequent Co-Authors

Andrew B. Singleton
Andrew B. Singleton National Institutes of Health
Rita Guerreiro
Rita Guerreiro Van Andel Institute
Henry Houlden
Henry Houlden University College London
Dena G. Hernandez
Dena G. Hernandez National Institutes of Health
Jose Bras
Jose Bras Van Andel Institute
Alison Goate
Alison Goate Icahn School of Medicine at Mount Sinai
Nicholas W. Wood
Nicholas W. Wood University College London
Mina Ryten
Mina Ryten University College London
Amanda J. Myers
Amanda J. Myers University of Miami
Andrew J. Lees
Andrew J. Lees University College London

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