D-Index & Metrics Best Publications
Research.com 2022 Best Scientist Award Badge
Genetics and Molecular Biology
UK
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 154 Citations 113,265 624 World Ranking 57 National Ranking 6
Medicine D-index 154 Citations 136,293 735 World Ranking 349 National Ranking 37
Best Scientists D-index 199 Citations 214,889 1,359 World Ranking 193 National Ranking 24

Research.com Recognitions

Awards & Achievements

2022 - Research.com Best Scientist Award

2022 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award

2018 - Member of Academia Europaea

1993 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

1984 - Fellow of the American Association for the Advancement of Science (AAAS)

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Genetics
  • Internal medicine

His primary areas of study are Genetics, Alzheimer's disease, Genome-wide association study, Disease and Single-nucleotide polymorphism. His biological study spans a wide range of topics, including Apolipoprotein E, Dementia and Degenerative disease. As a part of the same scientific study, he usually deals with the Genome-wide association study, concentrating on Quantitative trait locus and frequently concerns with Gene expression profiling and Transcriptome.

His research investigates the connection between Disease and topics such as Neuroscience that intersect with problems in Amyloid and Frontotemporal dementia. The concepts of his Single-nucleotide polymorphism study are interwoven with issues in Allele frequency and Bioinformatics. His study in Amyloid precursor protein is interdisciplinary in nature, drawing from both Transgene, Endocrinology and Presenilin.

His most cited work include:

  • The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics (10287 citations)
  • Alzheimer's disease: the amyloid cascade hypothesis (4421 citations)
  • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. (3929 citations)

What are the main themes of his work throughout his whole career to date?

John Hardy mainly investigates Genetics, Disease, Alzheimer's disease, Pathology and Gene. His Genetics study focuses mostly on Genome-wide association study, Locus, Allele, Single-nucleotide polymorphism and Haplotype. His research integrates issues of Genetic linkage and Linkage disequilibrium in his study of Locus.

The various areas that John Hardy examines in his Disease study include Neuroscience and Bioinformatics. His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Apolipoprotein E, Endocrinology and Age of onset. His Exon and Mutation study are his primary interests in Gene.

He most often published in these fields:

  • Genetics (47.32%)
  • Disease (30.58%)
  • Alzheimer's disease (18.05%)

What were the highlights of his more recent work (between 2016-2021)?

  • Disease (30.58%)
  • Genetics (47.32%)
  • Genome-wide association study (15.72%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Disease, Genetics, Genome-wide association study, Gene and Internal medicine. John Hardy has included themes like Allele and Cohort in his Disease study. His Genetics research incorporates themes from Alzheimer's disease and Frontotemporal dementia.

John Hardy interconnects Genetic variability, Expression quantitative trait loci, Genetic association and Locus in the investigation of issues within Genome-wide association study. His work in Gene covers topics such as Computational biology which are related to areas like Transcriptome and Candidate gene. His work carried out in the field of Internal medicine brings together such families of science as Polygenic risk score, Endocrinology and Oncology.

Between 2016 and 2021, his most popular works were:

  • Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. (588 citations)
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease (429 citations)
  • Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies (353 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Disease

His main research concerns Disease, Genetics, Genome-wide association study, Dementia and Internal medicine. His Disease study is mostly concerned with Apolipoprotein E, Alzheimer's disease, Amyloid precursor protein and Parkinson's disease. He focuses mostly in the field of Genetics, narrowing it down to matters related to Amyotrophic lateral sclerosis and, in some cases, Age of onset.

His Genome-wide association study research is multidisciplinary, incorporating elements of Minor allele frequency, Case-control study, Genetic association and Locus. His study in Dementia is interdisciplinary in nature, drawing from both HEK 293 cells, Computational biology and Amyloid. In his research on the topic of Internal medicine, Area under the curve and Meta-analysis is strongly related with Oncology.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

John Hardy;Dennis J. Selkoe.
Science (2002)

13593 Citations

Alzheimer's disease: the amyloid cascade hypothesis

John A. Hardy;Gerald A. Higgins.
Science (1992)

5909 Citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.

Alison Goate;Marie-Christine Chartier-Harlin;Mike Mullan;Jeremy Brown.
Nature (1991)

5417 Citations

Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium

I. G. McKeith;I. G. McKeith;D. W. Dickson;J. Lowe;M. Emre.
Neurology (2005)

4931 Citations

Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment.

B. Winblad;K. Palmer;Miia Kivipelto;V. Jelic.
Journal of Internal Medicine (2004)

4372 Citations

α-Synuclein Locus Triplication Causes Parkinson's Disease

A. B. Singleton;M. Farrer;J. Johnson;A. Singleton.
Science (2003)

4141 Citations

Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

D. Scheuner;C. Eckman;C. Eckman;M. Jensen;X. Song.
Nature Medicine (1996)

3937 Citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

M. Hutton;C. L. Lendon;P. Rizzu;M. Baker.
Nature (1998)

3532 Citations

A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

Alan E. Renton;Elisa Majounie;Adrian James Waite;Javier Simón-Sánchez;Javier Simón-Sánchez.
Neuron (2011)

3265 Citations

The amyloid hypothesis of Alzheimer's disease at 25 years

Dennis J Selkoe;John Hardy.
Embo Molecular Medicine (2016)

2625 Citations

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