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Genetics
UK
2024

D-Index & Metrics

Genetics

D-Index
122
Citations
65139
World Ranking
346
National Ranking
63

Medicine

D-Index
122
Citations
66772
World Ranking
3428
National Ranking
341

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award

Overview

Henry Houlden is affiliated with University College London in the United Kingdom and contributes extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields including molecular biology, genetics, neurology, cellular and molecular neuroscience, and cell biology.

The scientist's work focuses primarily on topics such as genetic neurodegenerative diseases, genetics and neurodevelopmental disorders, mitochondrial function and pathology, genomics and rare diseases, Parkinson's disease mechanisms and treatments, RNA regulation and disease, and neurological diseases and metabolism.

Henry Houlden has published research in a range of noteworthy journals and venues. The most frequent publication venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • Movement Disorders
  • The American Journal of Human Genetics
  • Genetics in Medicine

Recent significant papers include:

  • Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors, 2020, Nature Genetics
  • The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions, 2023, Nature Genetics
  • Deep Intronic FGF14 GAA Repeat Expansion in Late-Onset Cerebellar Ataxia, 2022, New England Journal of Medicine
  • Cerebellar ataxia, neuropathy, vestibular areflexia syndrome due to RFC1 repeat expansion, 2020, Brain
  • Finding genetically-supported drug targets for Parkinson's disease using Mendelian randomization of the druggable genome, 2021, Nature Communications

In collaborative research, Henry Houlden frequently coauthors with other scientists including:

  • Reza Maroofian
  • Stéphanie Efthymiou
  • Maha S. Zaki
  • John Hardy
  • Andrea Cortese

The combination of their research interests and publication record shows a concentration on the genetic and molecular basis of neurological disorders and neurodegeneration, including rare diseases and movement disorders such as Parkinson's disease and cerebellar ataxias.

Best Publications

  • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

    M. Hutton;C. L. Lendon;P. Rizzu;M. Baker

  • Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies

    Mike A Nalls;Cornelis Blauwendraat;Costanza L Vallerga;Karl Heilbron

  • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.

    Mike Mullan;Fiona Crawford;Karin Axelman;Henry Houlden

  • Genome-wide association study reveals genetic risk underlying Parkinson's disease

    Javier Simón-Sánchez;Claudia Schulte;Jose M Bras;Jose M Bras;Manu Sharma

  • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

    Mike A Nalls;Nathan Pankratz;Christina M. Lill;Chuong B. Do

  • Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

    Marie Christine Chartier-Harlin;Fiona Crawford;Henry Houlden;Andrew Warren

  • Genetic mechanisms of critical illness in Covid-19.

    E. Pairo-Castineira;E. Pairo-Castineira;S. Clohisey;L. Klaric;A. D. Bretherick

  • Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

    Elisa Majounie;Alan E. Renton;Kin Mok;Elise G. P. Dopper;Elise G. P. Dopper

  • Association of an extended haplotype in the tau gene with progressive supranuclear palsy.

    Matt Baker;Irene Litvan;Henry Houlden;Jennifer Adamson

  • A common polymorphism in the brain‐derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS

    Binith Cheeran;Penelope Talelli;Francesco Mori;Francesco Mori;Giacomo Koch;Giacomo Koch

  • Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

    Juliane Neumann;Jose Bras;Jose Bras;Emma Deas;Sean S. O'Sullivan

  • A novel α-synuclein missense mutation in Parkinson disease

    C Proukakis;CG Dudzik;T Brier;DS MacKay

  • Characterization of PLA2G6 as a locus for dystonia-parkinsonism.

    Coro Paisan-Ruiz;Kailash P. Bhatia;Kailash P. Bhatia;Abi Li;Dena Hernandez

  • Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

    Michael J. Devine;Mina Ryten;Petr Vodicka;Alison J. Thomson

  • α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson's disease and multiple system atrophy?

    Aoife P. Kiely;Yasmine T. Asi;Eleanna Kara;Patricia Limousin;Patricia Limousin

  • Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype

    H. Houlden;M. Baker;H. R. Morris;N. MacDonald

  • A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1

    Richard Crook;Auli Verkkoniemi;Jordi Perez-Tur;Nitin Mehta

  • Biallelic expansion of an intronic repeat in RFC1 is a common cause of late-onset ataxia

    Andrea Cortese;Roberto Simone;Roisin Sullivan;Jana Vandrovcova

  • Large C9orf72 hexanucleotide repeat expansions are seen in multiple neurodegenerative syndromes and are more frequent than expected in the UK population.

    Jon Beck;Mark Poulter;Davina Hensman;Jonathan D. Rohrer

  • Early onset familial Alzheimer’s disease Mutation frequency in 31 families

    JC Janssen;JA Beck;TA Campbell;A Dickinson

Frequent Co-Authors

Nicholas W. Wood
Nicholas W. Wood University College London
John Hardy
John Hardy University College London
Mary M. Reilly
Mary M. Reilly University College London
Kailash P. Bhatia
Kailash P. Bhatia University College London
Janice L. Holton
Janice L. Holton University College London
Michael G. Hanna
Michael G. Hanna University College London
Andrew J. Lees
Andrew J. Lees University College London
Tamas Revesz
Tamas Revesz University College London
Andrew B. Singleton
Andrew B. Singleton National Institutes of Health
Alan Pittman
Alan Pittman St George's, University of London

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