Mike Hutton mostly deals with Genetics, Alzheimer's disease, Tau protein, Mutation and Pathology. His Alzheimer's disease research is multidisciplinary, incorporating elements of Cell biology and Degenerative disease. His Tau protein research incorporates elements of Progressive supranuclear palsy, Chromosome 17 and Tauopathy.
His Tauopathy research includes elements of Neurofibrillary tangle and Hippocampus, Neuroscience. Mike Hutton combines subjects such as Frontotemporal lobar degeneration and Exon with his study of Mutation. His work deals with themes such as Endocrinology and Senile plaques, which intersect with Presenilin.
His main research concerns Genetics, Pathology, Tau protein, Frontotemporal dementia and Alzheimer's disease. The Tau protein study combines topics in areas such as Neurodegeneration, Tauopathy, Molecular biology, Cell biology and Neuroscience. The study incorporates disciplines such as Neurofibrillary tangle and Transgene in addition to Tauopathy.
His research investigates the connection with Frontotemporal dementia and areas like Parkinsonism which intersect with concerns in Mutation. His Alzheimer's disease study combines topics in areas such as Apolipoprotein E and Age of onset. His Presenilin research integrates issues from Pathogenesis and Senile plaques.
Neuroscience, Genetics, Alzheimer's disease, Cell biology and Pathology are his primary areas of study. The concepts of his Genetics study are interwoven with issues in Dystonia and Parkinsonism. Mike Hutton has included themes like Gene, Dementia, Immunology and Age of onset in his Alzheimer's disease study.
His Cell biology research includes themes of Caspase, Cleavage, Tau protein and Successful aging. His studies deal with areas such as Neuronal protein, Kinase and Tauopathy as well as Tau protein. His research integrates issues of Internal medicine and Genetically modified mouse in his study of Pathology.
The scientist’s investigation covers issues in Alzheimer's disease, Frontotemporal lobar degeneration, Mutation, Molecular biology and Frontotemporal dementia. Mike Hutton studies Tau protein which is a part of Alzheimer's disease. His Frontotemporal lobar degeneration research is within the category of Pathology.
Mutation is the subject of his research, which falls under Genetics. He focuses mostly in the field of Molecular biology, narrowing it down to topics relating to TARDBP and, in certain cases, Exon, TAR DNA-Binding Protein 43, Neurodegeneration, Amyotrophic lateral sclerosis and Missense mutation. His research investigates the connection between Frontotemporal dementia and topics such as Parkinsonism that intersect with issues in Primary progressive aphasia, Atrophy, Chromosome 17 and Tauopathy.
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Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
D. Scheuner;C. Eckman;C. Eckman;M. Jensen;X. Song.
Nature Medicine (1996)
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
M. Hutton;C. L. Lendon;P. Rizzu;M. Baker.
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
K. SantaCruz;J. Lewis;T. Spires;J. Paulson.
Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
Matt Baker;Ian R. Mackenzie;Stuart M. Pickering-Brown;Jennifer Gass.
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Karen Duff;Karen Duff;Chris Eckman;Cindy Zehr;Cindy Zehr;Xin Yu.
Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP.
Jada Lewis;Dennis W. Dickson;Wen-Lang Lin;Louise Chisholm.
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein.
Jada Lewis;Eileen McGowan;Julia Rockwood;Heather Melrose.
Nature Genetics (2000)
Tauopathy in Drosophila: Neurodegeneration Without Neurofibrillary Tangles
Curtis W. Wittmann;Matthew F. Wszolek;Joshua M. Shulman;Paul M. Salvaterra.
Association of an extended haplotype in the tau gene with progressive supranuclear palsy.
Matt Baker;Irene Litvan;Henry Houlden;Jennifer Adamson.
Human Molecular Genetics (1999)
TDP‐43 immunoreactivity in hippocampal sclerosis and Alzheimer's disease
Catalina Amador-Ortiz;Wen Lang Lin;Zeshan Ahmed;David Personett.
Annals of Neurology (2007)
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