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2025
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Medicine
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2023

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Best Scientists

D-Index
281
Citations
321263
World Ranking
23
National Ranking
17

Neuroscience

D-Index
289
Citations
344118
World Ranking
1
National Ranking
1

Medicine

D-Index
289
Citations
344567
World Ranking
11
National Ranking
10

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2022 - Research.com Neuroscience in United States Leader Award
  • 2014 - J. Allyn Taylor International Prize in Medicine, Robarts Research Institute
  • 2012 - Fellow, National Academy of Inventors
  • 2012 - Robert J. and Claire Pasarow Foundation Medical Research Award
  • 2002 - Member of the National Academy of Medicine (NAM)
  • 1998 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 1998 - Sedgwick Memorial Medal, American Public Health Association
  • 1996 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

John Q. Trojanowski was affiliated with the University of Pennsylvania in the United States. Their research primarily focused on medicine, with significant contributions in subfields including neurology, physiology, psychiatry and mental health, molecular biology, and radiology, nuclear medicine, and imaging.

Their work covered several main topics, such as Alzheimer's disease research and treatments, Parkinson's disease mechanisms and treatments, dementia and cognitive impairment research, advanced neuroimaging techniques and applications, functional brain connectivity studies, amyotrophic lateral sclerosis research, and neuroinflammation and neurodegeneration mechanisms.

Trojanowski published extensively, with frequent co-authors including David J. Irwin, Murray Grossman, Edward B. Lee, David A. Wolk, and Virginia M.-Y. Lee.

The scientist's recent papers included:

  • Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation (2020, Nature Medicine)
  • Protein transmission in neurodegenerative disease (2020, Nature Reviews Neurology)
  • Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease (2020, Journal of Clinical Investigation)
  • Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study (2020, Nature Communications)
  • Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture (2021, Nature Genetics)

The most frequent publication venues for Trojanowski's work were:

  • Alzheimer s & Dementia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Reviews in the Neurosciences
  • Acta Neuropathologica
  • Acta Neuropathologica Communications

Throughout their career, Trojanowski received various awards including the J. Allyn Taylor International Prize in Medicine from Robarts Research Institute in 2014, election as a Fellow of the National Academy of Inventors in 2012, the Robert J. and Claire Pasarow Foundation Medical Research Award in 2012, membership in the National Academy of Medicine since 2002, the Sedgwick Memorial Medal from the American Public Health Association in 1998, the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases from the American Academy of Neurology in 1998, and the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1996. Trojanowski was also a member of the Association of American Physicians.

Best Publications

  • Alpha-synuclein in Lewy bodies.

    Maria Grazia Spillantini;Marie Luise Schmidt;Virginia M.-Y. Lee;John Q. Trojanowski

  • Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

    Manuela Neumann;Deepak M. Sampathu;Linda K. Kwong;Adam C. Truax

  • Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium

    I. G. McKeith;I. G. McKeith;D. W. Dickson;J. Lowe;M. Emre

  • Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

    Clifford R Jack;David S Knopman;William J Jagust;Leslie M Shaw

  • Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.

    Clifford R Jack;David S Knopman;William J Jagust;Ronald C Petersen

  • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

    M. Hutton;C. L. Lendon;P. Rizzu;M. Baker

  • Diagnosis and management of dementia with Lewy bodies Fourth consensus report of the DLB Consortium

    Ian G. McKeith;Bradley F. Boeve;Dennis W. DIckson;Glenda Halliday

  • Second consensus statement on the diagnosis of multiple system atrophy

    S. Gilman;G. K. Wenning;P. A. Low;D. J. Brooks

  • National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

    Bradley T. Hyman;Creighton H. Phelps;Thomas G. Beach;Eileen H. Bigio

  • Transplantation of embryonic dopamine neurons for severe Parkinson's disease.

    Curt R. Freed;Paul E. Greene;Robert E. Breeze;Wei-Yann Tsai

  • National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

    Thomas J. Montine;Creighton H. Phelps;Thomas G. Beach;Eileen H. Bigio

  • Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

    Kelvin C. Luk;Victoria Kehm;Jenna Carroll;Bin Zhang

  • Tau-mediated neurodegeneration in Alzheimer's disease and related disorders.

    Carlo Ballatore;Virginia M.-Y. Lee;John Q. Trojanowski

  • Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

    Yasumasa Yoshiyama;Makoto Higuchi;Bin Zhang;Shu-Ming Huang

  • Editorial on Consensus Recommendations for the Postmortem Diagnosis of Alzheimer Disease from the National Institute on Aging and the Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer Disease

    Bradley T. Hyman;John Q. Trojanowski

  • Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects.

    Leslie M. Shaw;Hugo Vanderstichele;Malgorzata Knapik-Czajka;Christopher M. Clark

  • Alzheimer's Disease Neuroimaging Initiative (ADNI): clinical characterization.

    R. C. Petersen;P. S. Aisen;Laurel A Beckett;M. C. Donohue

  • Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

    Peter T Nelson;Irina Alafuzoff;Eileen H Bigio;Constantin Bouras

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Alzheimer's Disease Neuroimaging Initiative

    Susanne G. Mueller;Michael W. Weiner;Leon J. Thal;Ronald C. Petersen

  • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

    M. Baba;S. Nakajo;P.-H. Tu;T. Tomita

Frequent Co-Authors

Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Leslie M. Shaw
Leslie M. Shaw University of Pennsylvania
Murray Grossman
Murray Grossman University of Pennsylvania
Vivianna M. Van Deerlin
Vivianna M. Van Deerlin University of Pennsylvania
Michael W. Weiner
Michael W. Weiner University of California, San Francisco
David J. Irwin
David J. Irwin University of Pennsylvania
Steven E. Arnold
Steven E. Arnold Harvard University
Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Jon B. Toledo
Jon B. Toledo Houston Methodist
Sharon X. Xie
Sharon X. Xie University of Pennsylvania

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Best Scientists Citing John Q. Trojanowski