His scientific interests lie mostly in Pathology, Dementia, Frontotemporal lobar degeneration, Amyotrophic lateral sclerosis and Disease. His Pathology study frequently links to related topics such as White matter. His work in Dementia covers topics such as Alzheimer's disease which are related to areas like Dementia with Lewy bodies and Biomarker.
David J. Irwin has included themes like Progressive supranuclear palsy and Frontal lobe in his Frontotemporal lobar degeneration study. The concepts of his Amyotrophic lateral sclerosis study are interwoven with issues in C9orf72 Protein, C9orf72, Anatomy and Atrophy. His Disease study integrates concerns from other disciplines, such as Neuroscience and Oncology.
David J. Irwin focuses on Pathology, Frontotemporal lobar degeneration, Frontotemporal dementia, Disease and Dementia. His work on White matter expands to the thematically related Pathology. His study in Frontotemporal lobar degeneration is interdisciplinary in nature, drawing from both Primary progressive aphasia, C9orf72, Progressive supranuclear palsy and Oncology.
His Frontotemporal dementia research is multidisciplinary, relying on both Tau protein, Neuropsychology, Psychiatry, Asymptomatic and Neuroscience. David J. Irwin interconnects Differential diagnosis and Autopsy in the investigation of issues within Disease. His Dementia research is multidisciplinary, incorporating perspectives in Alzheimer's disease, Cognition and Parkinson's disease.
David J. Irwin spends much of his time researching Pathology, Frontotemporal dementia, Frontotemporal lobar degeneration, Disease and Atrophy. The concepts of his Pathology study are interwoven with issues in Temporal lobe and In vivo. In general Frontotemporal dementia, his work in C9orf72 is often linked to Grossman linking many areas of study.
His Frontotemporal lobar degeneration research is multidisciplinary, relying on both Primary progressive aphasia, Clinical Dementia Rating, Corticobasal degeneration and Cerebrospinal fluid. David J. Irwin works in the field of Disease, namely Progressive supranuclear palsy. His research investigates the link between Alzheimer's disease and topics such as Dementia that cross with problems in Positron emission tomography and Oncology.
Frontotemporal dementia, Frontotemporal lobar degeneration, Atrophy, Disease and Neuropathology are his primary areas of study. In the subject of general Frontotemporal dementia, his work in C9orf72 is often linked to Grossman, thereby combining diverse domains of study. His research in Frontotemporal lobar degeneration intersects with topics in TAR DNA-BINDING PROTEIN, Unknown Significance, Audiology, Clinical Dementia Rating and Primary progressive aphasia.
His Disease research is within the category of Pathology. His Pathology research incorporates themes from Biochemical biomarkers and Appropriate Use Criteria. His Neuropathology study incorporates themes from Dementia with Lewy bodies, Dementia, Cohort and Autopsy.
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Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria
Günter U Höglinger;Gesine Respondek;Maria Stamelou;Carolin Kurz.
Movement Disorders (2017)
Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
Johannes Brettschneider;Kelly Del Tredici;Jon B. Toledo;John L. Robinson.
Annals of Neurology (2013)
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
David J. Irwin;Virginia M.-Y. Lee;John Q. Trojanowski.
Nature Reviews Neuroscience (2013)
Neuropathologic substrates of Parkinson disease dementia.
David J. Irwin;Matthew T. White;Jon B. Toledo;Sharon X. Xie.
Annals of Neurology (2012)
Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease
Ju-Hee Kang;Ju-Hee Kang;David J. Irwin;Alice S. Chen-Plotkin;Andrew Siderowf.
JAMA Neurology (2013)
APOE ε4 increases risk for dementia in pure synucleinopathies.
Debby Tsuang;James B. Leverenz;Oscar L. Lopez;Ronald L. Hamilton.
JAMA Neurology (2013)
Neuropathological and Genetic Correlates of Survival and Dementia Onset in Synucleinopathies: A Retrospective Analysis
David J Irwin;Murray Grossman;Daniel Weintraub;Daniel Weintraub;Howard I Hurtig.
Lancet Neurology (2017)
Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)
Johannes Brettschneider;Johannes Brettschneider;Kelly Del Tredici;David J. Irwin;Murray Grossman.
Acta Neuropathologica (2014)
Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated
John L Robinson;Edward B Lee;Sharon X Xie;Lior Rennert.
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion
Johannes Brettschneider;Johannes Brettschneider;Vivianna M. Van Deerlin;John L. Robinson;Linda Kwong.
Acta Neuropathologica (2012)
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