David J. Irwin

Overview

Best Publications

• Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

  Günter U Höglinger;Gesine Respondek;Maria Stamelou;Carolin Kurz

  2243
  Citations

• Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

  Johannes Brettschneider;Kelly Del Tredici;Jon B. Toledo;John L. Robinson

  1111
  Citations

• Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

  David J. Irwin;Virginia M.-Y. Lee;John Q. Trojanowski

  978
  Citations

• Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

  John L Robinson;Edward B Lee;Sharon X Xie;Lior Rennert

  707
  Citations

• Neuropathologic substrates of Parkinson disease dementia.

  David J. Irwin;Matthew T. White;Jon B. Toledo;Sharon X. Xie

  597
  Citations

• Neuropathological and Genetic Correlates of Survival and Dementia Onset in Synucleinopathies: A Retrospective Analysis

  David J Irwin;Murray Grossman;Daniel Weintraub;Daniel Weintraub;Howard I Hurtig

  573
  Citations

• APOE ε4 increases risk for dementia in pure synucleinopathies.

  Debby Tsuang;James B. Leverenz;Oscar L. Lopez;Ronald L. Hamilton

  438
  Citations

• Distribution patterns of tau pathology in progressive supranuclear palsy

  Gabor G. Kovacs;Gabor G. Kovacs;Gabor G. Kovacs;Milica Jecmenica Lukic;Milica Jecmenica Lukic;David J. Irwin;Thomas Arzberger

  427
  Citations

• Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

  Adam S Fleisher;Michael J Pontecorvo;Michael D Devous;Ming Lu

  416
  Citations

• Association of Cerebrospinal Fluid β-Amyloid 1-42, T-tau, P-tau181, and α-Synuclein Levels With Clinical Features of Drug-Naive Patients With Early Parkinson Disease

  Ju-Hee Kang;Ju-Hee Kang;David J. Irwin;Alice S. Chen-Plotkin;Andrew Siderowf

  398
  Citations

• Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD)

  Johannes Brettschneider;Johannes Brettschneider;Kelly Del Tredici;David J. Irwin;Murray Grossman

  334
  Citations

• Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies

  David J. Irwin;Todd J. Cohen;Murray Grossman;Steven E. Arnold

  301
  Citations

• Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

  Katrina M. Moore;Jennifer Nicholas;Murray Grossman;Corey T. McMillan

  299
  Citations

• TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord

  Johannes Brettschneider;Kimihito Arai;Kelly Del Tredici;Jon B. Toledo

  298
  Citations

• Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine

  David J. Irwin;Nigel J. Cairns;Murray Grossman;Corey T. McMillan

  285
  Citations

• Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration

  Edward B. Lee;Sílvia Porta;G. Michael Baer;Yan Xu

  260
  Citations

• Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders

  Bob Olsson;Bob Olsson;Erik Portelius;Erik Portelius;Nicholas C. Cullen;Nicholas C. Cullen;Åsa Sandelius

  250
  Citations

• A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

  Jon B. Toledo;Vivianna M. Van Deerlin;Edward B. Lee;EunRan Suh

  238
  Citations

• Deep clinical and neuropathological phenotyping of Pick disease.

  David J. Irwin;Johannes Brettschneider;Corey T. McMillan;Felicia Cooper

  235
  Citations

• Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion

  Johannes Brettschneider;Johannes Brettschneider;Vivianna M. Van Deerlin;John L. Robinson;Linda Kwong

  235
  Citations

• C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD

  Elaine Y. Liu;Jenny Russ;Kathryn Wu;Donald Neal

  204
  Citations