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Immunology

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91
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23360
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1053
National Ranking
569

Medicine

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91
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Overview

Steven Jacobson is affiliated with the National Institutes of Health in the United States and has contributed extensively to medical research, particularly in the fields of immunology, microbiology, and neurology.

Their research spans multiple subfields including immunology, pathology and forensic medicine, neurology, oncology, and molecular biology. The main areas of focus include multiple sclerosis research studies, T-cell and retrovirus studies, polyomavirus and related diseases, neuroinflammation and neurodegeneration mechanisms, cytomegalovirus and herpesvirus research, vector-borne animal diseases, and systemic lupus erythematosus research.

Steven Jacobson has published work in a range of scientific journals and venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neurology Neuroimmunology & Neuroinflammation
  • Nature Communications
  • Neurology
  • Journal of Clinical Investigation

Their recent papers include:

  • Paramagnetic Rim Lesions are Specific to Multiple Sclerosis: An International Multicenter 3T MRI Study, 2020, Annals of Neurology
  • Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases, 2023, Nature Communications
  • Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD, 2024, Science Translational Medicine
  • Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts, 2020, Neuron
  • Human Herpesviruses 6A and 6B in Brain Diseases: Association versus Causation, 2020, Clinical Microbiology Reviews

Frequent co-authors in Steven Jacobson's body of work include:

  • Daniel S. Reich
  • Joan Ohayon
  • Irene Cortese
  • Govind Nair
  • Yoshimi Enose-Akahata

Steven Jacobson's contributions refine understanding in several domains of medicine and have been disseminated through extensive publication in prominent journals, focusing particularly on inflammatory and infectious disease processes and neurodegeneration.

Best Publications

  • Circulating CD8 + cytotoxic T lymphocytes specific for HTLV-I pX in patients with HTLV-I associated neurological disease

    Steven Jacobson;Hisatoshi Shida;Dale E. McFarlin;Anthony S. Fauci

  • Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA.

    Samantha S. Soldan;Rossana Berti;Nazi Salem;Paola Secchiero

  • Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

    Brent L. Williams;Mady Hornig;Timothy Buie;Margaret L. Bauman

  • Clinicopathologic correlations in 172 cases of rapid eye movement sleep behavior disorder with or without a coexisting neurologic disorder.

    B. F. Boeve;M. H. Silber;T. J. Ferman;S. C. Lin

  • Classification of HHV-6A and HHV-6B as distinct viruses.

    Dharam Ablashi;Henri Agut;Roberto Alvarez-Lafuente;Duncan A. Clark

  • Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8(+) T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP).

    Yoshihisa Yamano;Masahiro Nagai;Meghan Brennan;Carlos A. Mora

  • Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomographic imaging of this inflammation biomarker.

    William C. Kreisl;Masahiro Fujita;Yota Fujimura;Yota Fujimura;Nobuyo Kimura

  • Direct visualization of antigen-specific T cells: HTLV-1 Tax11–19- specific CD8+ T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients

    Tim F. Greten;Jill E. Slansky;Ryuji Kubota;Samantha S. Soldan

  • Isolation of an HTLV-1-like retrovirus from patients with tropical spastic paraparesis

    Steven Jacobson;Cedric S. Raine;Elizabeth S. Mingioli;Dale E. McFarlin

  • Pembrolizumab Treatment for Progressive Multifocal Leukoencephalopathy

    Irene Cortese;Pawel Muranski;Yoshimi Enose-Akahata;Seung-Kwon Ha

  • Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions

    Martina Absinta;Martina Absinta;Pascal Sati;Matthew Schindler;Emily C. Leibovitch

  • Measles virus-specific T4+ human cytotoxic T cell clones are restricted by class II HLA antigens.

    S Jacobson;J R Richert;W E Biddison;A Satinsky

  • High human T cell lymphotropic virus type 1 (HTLV-1)-specific precursor cytotoxic T lymphocyte frequencies in patients with HTLV-1-associated neurological disease.

    I Elovaara;S Koenig;A Y Brewah;R M Woods

  • HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cells.

    S Jacobson;R P Sekaly;C L Jacobson;H F McFarland

  • Detection of human herpesvirus-6 in mesial temporal lobe epilepsy surgical brain resections.

    D. Donati;N. Akhyani;A. Fogdell-Hahn;C. Cermelli;C. Cermelli

  • Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I–associated myelopathy/tropical spastic paraparesis patients by in situ hybridization

    T J Lehky;C H Fox;S Koenig;M C Levin

  • Tissue Distribution and Variant Characterization of Human Herpesvirus (HHV)—6: Increased Prevalence of HHV-6A in Patients with Multiple Sclerosis

    Nahid Akhyani;Rossana Berti;Meghan B. Brennan;Samantha S. Soldan;Samantha S. Soldan

  • CD8+ T cells are an in vivo reservoir for human T-cell lymphotropic virus type I

    Masahiro Nagai;Meghan B. Brennan;Jill A. Sakai;Carlos A. Mora

  • Isolation of human T-cell lymphotropic virus type 2 from Guaymi Indians in Panama.

    Michael Dale Lairmore;Steven Jacobson;Fernando Gracia;Barun K. De

  • Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP.

    Masahiro Nagai;Yoshihisa Yamano;Meghan B. Brennan;Carlos A. Mora

  • Exosomes in Viral Disease

    Monique R. Anderson;Monique R. Anderson;Fatah Kashanchi;Steven Jacobson

  • Human T cell leukemia virus type I (HTLV-I)-specific CD8+ CTL clones from patients with HTLV-I-associated neurologic disease secrete proinflammatory cytokines, chemokines, and matrix metalloproteinase.

    W E Biddison;R Kubota;T Kawanishi;D D Taub

  • Association of Human Herpesvirus-6B with Mesial Temporal Lobe Epilepsy

    Julie Fotheringham;Donatella Donati;Nahid Akhyani;Anna Fogdell-Hahn;Anna Fogdell-Hahn

  • Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11-19-specific memory and effector CD8+ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load.

    Masahiro Nagai;Ryuji Kubota;Tim F. Greten;Jonathan P. Schneck

  • Human herpesvirus-6 entry into the central nervous system through the olfactory pathway

    Erin Harberts;Karen Yao;Jillian E. Wohler;Dragan Maric

  • Virus-induced dysfunction of CD4 + CD25 + T cells in patients with HTLV-I–associated neuroimmunological disease

    Yoshihisa Yamano;Norihiro Takenouchi;Hong-Chuan Li;Utano Tomaru

  • Increased lymphoproliferative response to human herpesvirus type 6A variant in multiple sclerosis patients

    Samantha S. Soldan;Samantha S. Soldan;Thomas P. Leist;K. Newton Juhng;Henry F. McFarland

  • High Human T Cell Lymphotropic Virus Type 1 (HTLV-1)-specific Precursor Cytotoxic T Lymphocyte Frequencies in Patients with HTLV-l-associated Neurological Disease By Irina Elovaara,* Scott Koenig,~ A. Yambusu Brewah,~

    Robert M. Woods;Tanya Lehky;Steven Jacobson

Frequent Co-Authors

Henry F. McFarland
Henry F. McFarland National Institutes of Health
Daniel S. Reich
Daniel S. Reich National Institutes of Health
Dale E. McFarlin
Dale E. McFarlin National Institutes of Health
Michael Levin
Michael Levin Tufts University
Yuetsu Tanaka
Yuetsu Tanaka University of the Ryukyus
Afonso C. Silva
Afonso C. Silva University of Pittsburgh
Genoveffa Franchini
Genoveffa Franchini National Institutes of Health
Thomas A. Waldmann
Thomas A. Waldmann National Institutes of Health
Fatah Kashanchi
Fatah Kashanchi George Mason University
Atae Utsunomiya
Atae Utsunomiya Kagoshima University

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