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Steven G. Younkin

Steven G. Younkin

D-Index & Metrics

Biology and Biochemistry

D-Index
123
Citations
94238
World Ranking
543
National Ranking
344

Medicine

D-Index
123
Citations
94308
World Ranking
3264
National Ranking
1802

Research.com Recognitions

  • 1997 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 1995 - Sedgwick Memorial Medal, American Public Health Association
  • 1995 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

Overview

Steven G. Younkin is affiliated with the Mayo Clinic in the United States and specializes in research within the field of medicine, with particular focus on physiology and psychiatry and mental health.

Their work concentrates on several interconnected topics, including:

  • Alzheimer's disease research and treatments
  • Diet and metabolism studies
  • Dementia and cognitive impairment research

A notable publication by Steven G. Younkin is titled "Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study", published in 2020 in Nature Communications. This paper has received significant attention in the scientific community, reflecting 449 citations.

Their frequent coauthors include:

  • Eric M. Reiman
  • Joseph F. Arboleda-Velásquez
  • Yakeel T. Quiroz
  • Matthew J. Huentelman
  • Thomas G. Beach

Steven G. Younkin's research has been published predominantly in Nature Communications, which remains one of the key venues for their scientific contributions.

Throughout their career, Steven G. Younkin has received several awards including:

  • Metlife Foundation Award for Medical Research in Alzheimer's Disease (1997)
  • Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology (1995)
  • Sedgwick Memorial Medal, American Public Health Association (1995)

Best Publications

  • Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

    Karen Hsiao;Paul Chapman;Steven Nilsen;Chris Eckman

  • Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

    Jean-Charles Lambert;Jean-Charles Lambert;Jean-Charles Lambert;Carla A Ibrahim-Verbaas;Denise Harold;Adam C Naj

  • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.

    D. Scheuner;C. Eckman;C. Eckman;M. Jensen;X. Song

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • TREM2 Variants in Alzheimer's Disease

    Rita Guerreiro;Rita Guerreiro;Aleksandra Wojtas;Jose Bras;Minerva Carrasquillo

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants

    Nobuhiro Suzuki;Tobun T. Cheung;Xiao Dan Cai;Asano Odaka

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.

    Adam C. Naj;Gyungah Jun;Gary W. Beecham;Li-San Wang

  • Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

    David R. Borchelt;Gopal Thinakaran;Christopher B. Eckman;Christopher B. Eckman;Michael K. Lee

  • Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

    Karen Duff;Karen Duff;Chris Eckman;Cindy Zehr;Cindy Zehr;Xin Yu

  • Production of the Alzheimer amyloid β protein by normal proteolytic processing

    Mikio Shoji;Todd E. Golde;Jorge Ghiso;Tobun T. Cheung

  • Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

    Leigh Holcomb;Marcia N. Gordon;Eileen Mcgowan;Xin Yu

  • Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

    Joanna L. Jankowsky;Joanna L. Jankowsky;Daniel J. Fadale;Jeffrey Anderson;Guilian M. Xu

  • Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

    Xiao Dan Cai;Todd E. Golde;Steven G. Younkin

  • Genome-wide analysis of genetic loci associated with Alzheimer disease.

    Sudha Seshadri;Annette L. Fitzpatrick;M Arfan Ikram;Anita L. DeStefano

  • The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.

    Camilla Nilsberth;Anita Westlind-Danielsson;Anita Westlind-Danielsson;Christopher B. Eckman;Margaret M. Condron

  • The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

    Ekaterina Rogaeva;Ekaterina Rogaeva;Yan Meng;Joseph H. Lee;Yongjun Gu;Yongjun Gu

  • Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

    Valentina Escott-Price;Céline Bellenguez;Li-San Wang;Seung-Hoan Choi

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

Frequent Co-Authors

Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Todd E. Golde
Todd E. Golde Emory University
Kevin Morgan
Kevin Morgan University of Nottingham
Sarah Lincoln
Sarah Lincoln Mayo Clinic
Gerard D. Schellenberg
Gerard D. Schellenberg University of Pennsylvania
Yan W. Asmann
Yan W. Asmann Mayo Clinic

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