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Sarah Lincoln

Sarah Lincoln

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
30652
World Ranking
9960
National Ranking
4361

Overview

Sarah Lincoln is affiliated with the Mayo Clinic in the United States and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans several subfields, including molecular biology, physiology, neurology, immunology, and psychiatry and mental health.

Their work focuses on topics related to Alzheimer's disease research and treatments, bioinformatics and genomic networks, dementia and cognitive impairment research, epigenetics and DNA methylation, neuroinflammation and neurodegeneration mechanisms, immune cells in cancer, and atherosclerosis and cardiovascular diseases.

Among the recent papers authored by Sarah Lincoln are:

  • Deciphering cellular transcriptional alterations in Alzheimer's disease brains (2020, Molecular Neurodegeneration)
  • Transcriptional landscape of human microglia implicates age, sex, and APOE-related immunometabolic pathway perturbations (2022, Aging Cell)
  • Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease (2021, Acta Neuropathologica Communications)
  • Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease (2020, Acta Neuropathologica Communications)
  • Association of ABI3 and PLCG2 missense variants with disease risk and neuropathology in Lewy body disease and progressive supranuclear palsy (2020, Acta Neuropathologica Communications)

Frequent coauthors in their research include Nilüfer Ertekin-Taner, Kimberly G. Malphrus, Thuy Nguyen, Dennis W. Dickson, and Joseph S. Reddy.

Their publications frequently appear in the following venues:

  • Alzheimer s & Dementia
  • Acta Neuropathologica Communications
  • Molecular Neurodegeneration
  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal

Sarah Lincoln's research provides insights into molecular and cellular mechanisms underlying neurodegenerative diseases, with a particular emphasis on Alzheimer's disease and related neuropathologies. Their work incorporates genomic and bioinformatic approaches to investigate disease pathways and molecular variants relevant to neuroinflammation and vascular amyloid pathology.

Best Publications

  • α-Synuclein Locus Triplication Causes Parkinson's Disease

    A. B. Singleton;M. Farrer;J. Johnson;A. Singleton

  • Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

    M. Hutton;C. L. Lendon;P. Rizzu;M. Baker

  • Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology

    Alexander Zimprich;Alexander Zimprich;Saskia Biskup;Petra Leitner;Peter Lichtner

  • α-synuclein locus duplication as a cause of familial Parkinson's disease

    Marie-Christine Chartier-Harlin;Jennifer M. Kachergus;Christophe Roumier;Vincent Mouroux

  • VPS35 Mutations in Parkinson Disease

    Carles Vilariño-Güell;Christian Wider;Owen A. Ross;Justus C. Dachsel

  • Comparison of kindreds with parkinsonism and α‐synuclein genomic multiplications

    Matt Farrer;Jennifer Kachergus;Lysia Forno;Sarah Lincoln

  • Lewy bodies and parkinsonism in families with parkin mutations.

    M Farrer;P Chan;R Chen;L Tan

  • Identification of a Novel LRRK2 Mutation Linked to Autosomal Dominant Parkinsonism: Evidence of a Common Founder across European Populations

    Jennifer Kachergus;Ignacio F. Mata;Mary Hulihan;Julie P. Taylor

  • Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.

    Demetrius M. Maraganore;Mariza De Andrade;Alexis Elbaz;Matthew J. Farrer

  • Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

    Mariet Allen;Minerva M. Carrasquillo;Cory Funk;Benjamin D. Heavner

  • A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1

    Richard Crook;Auli Verkkoniemi;Jordi Perez-Tur;Nitin Mehta

  • A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

    Harald Steiner;Karen Duff;Anja Capell;Helmut Romig

  • Translation initiator EIF4G1 mutations in familial Parkinson disease

    Marie Christine Chartier-Harlin;Marie Christine Chartier-Harlin;Justus C. Dachsel;Carles Vilariño-Güell;Sarah J. Lincoln

  • A Chromosome 4P Haplotype Segregating with Parkinson's Disease and Postural Tremor

    Matt Farrer;Katrina Gwinn-Hardy;Manfred Muenter;Fabienne Wavrant DeVrieze

  • Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter.

    Yasuji Matsuoka;Miquel Vila;Sarah Lincoln;Alison McCormack

  • Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia

    Rosa Rademakers;Jason L. Eriksen;Matt Baker;Todd Robinson

  • Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice.

    H. L. Melrose;J. C. Dächsel;B. Behrouz;S. J. Lincoln

  • Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease.

    D. M. Maraganore;M. J. Farrer;J. A. Hardy;S. J. Lincoln

  • Parkinsonism, Lrrk2 G2019S, and tau neuropathology.

    A. Rajput;D. W. Dickson;C. A. Robinson;C. A. Robinson;O. A. Ross

  • Lrrk2 pathogenic substitutions in Parkinson's disease

    Ignacio F. Mata;Jennifer M. Kachergus;Julie P. Taylor;Sarah Lincoln

Frequent Co-Authors

Matthew J. Farrer
Matthew J. Farrer University of Florida
Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Owen A. Ross
Owen A. Ross Mayo Clinic
Yan W. Asmann
Yan W. Asmann Mayo Clinic

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