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Genetics

D-Index
49
Citations
11903
World Ranking
3981
National Ranking
1720

Overview

James M. Sikela is affiliated with the University of Colorado Denver in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with a particular emphasis on Genetics, Molecular Biology, and Plant Science as subfields.

They have contributed significantly to several main topics including:

  • Chromosomal and Genetic Variations
  • Genomic variations and chromosomal abnormalities
  • Genetics and Neurodevelopmental Disorders
  • Mitochondrial Function and Pathology
  • RNA modifications and cancer
  • Metabolism and Genetic Disorders
  • Advanced NMR Techniques and Applications

James M. Sikela's recent publications span from 2020 to 2024 and are featured in several scientific venues. Notable papers include:

  • "Proteolytic activation of human-specific Olduvai domains by the furin protease," 2022, International Journal of Biological Macromolecules
  • "Proteolytic Activation of Human-specific Olduvai Domains by the Furin Protease," 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • "Solution NMR backbone assignments of disordered Olduvai protein domain CON1 employing Hα-detected experiments," 2022, Biomolecular NMR Assignments
  • "Olduvai domain expression downregulates mitochondrial pathways: implications for human brain evolution and neoteny," 2024, bioRxiv (Cold Spring Harbor Laboratory)
  • "The ethics of using transgenic non-human primates to study what makes us human," 2020, UNC Libraries

Their work frequently appears in venues such as bioRxiv (Cold Spring Harbor Laboratory), International Journal of Biological Macromolecules, Biomolecular NMR Assignments, and UNC Libraries.

James M. Sikela has collaborated extensively with various coauthors, with several frequent collaborators including:

  • Beat Vögeli
  • Aaron Issaian
  • Jonathan M. Davis
  • Nathan Anderson
  • Kirk C. Hansen

Best Publications

  • Evolutionary and biomedical insights from the rhesus macaque genome

    Richard A. Gibbs;Jeffrey Rogers

  • A gene map of the human genome

    G. D. Schuler;M. S. Boguski;E. A. Stewart;L. D. Stein

  • A Physical Map of 30,000 Human Genes

    P. Deloukas;G. D. Schuler;G. Gyapay;E. M. Beasley

  • The nature and identification of quantitative trait loci: a community's view.

    Oduola Abiola;Joe M. Angel;Philip Avner;Alexander A. Bachmanov

  • Ethanol sensitivity of the GABAA receptor expressed in xenopus oocytes requires 8 amino acids contained in the γ2L subunit

    Keith A. Wafford;Donald M. Burnett;Nancy J. Leidenheimer;David R. Burt

  • Lineage-Specific Gene Duplication and Loss in Human and Great Ape Evolution

    Andrew Fortna;Young Kim;Erik MacLaren;Kriste Marshall

  • Gibbon genome and the fast karyotype evolution of small apes

    Lucia Carbone;R. Alan Harris;Sante Gnerre;Krishna R. Veeramah;Krishna R. Veeramah

  • Functional characterization of human gamma-aminobutyric acidA receptors containing the alpha 4 subunit.

    K A Wafford;S A Thompson;D Thomas;J Sikela

  • Ethanol-Responsive Brain Region Expression Networks: Implications for Behavioral Responses to Acute Ethanol in DBA/2J versus C57BL/6J Mice

    Robnet T. Kerns;Ajay Ravindranathan;Sajida Hassan;Mary P. Cage

  • Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.

    K L Hadingham;P B Wingrove;K A Wafford;C Bain

  • Human LineageSpecific Amplification, Selection, and Neuronal Expression of DUF1220 Domains

    Magdalena C. Popesco;Erik J. MacLaren;Janet Hopkins;Laura Dumas

  • Single pass sequencing and physical and genetic mapping of human brain cDNAs.

    Akbar S. Khan;Akbar S. Khan;Andrea S. Wilcox;Andrea S. Wilcox;Mihael H. Polymeropoulos;Janet A. Hopkins

  • Gene copy number variation spanning 60 million years of human and primate evolution

    Laura Dumas;Young H. Kim;Anis Karimpour-Fard;Michael Cox

  • Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement.

    Michael K. Dush;James M. Sikela;Sohaib A. Khan;Jay A. Tischfield

  • Activation mechanisms for Ca2+/calmodulin-dependent protein kinase IV. Identification of a brain CaM-kinase IV kinase.

    Hiroshi Tokumitsu;Debra A. Brickey;John Glod;Hiroyoshi Hidaka

  • Evolution of genetic and genomic features unique to the human lineage.

    Majesta O'Bleness;Veronica B. Searles;Ajit Varki;Pascal Gagneux

  • Use of 3' untranslated sequences of human cDNAs for rapid chromosome assignment and conversion to STSs: implications for an expression map of the genome

    Andrea S. Wilcox;Andrea S. Wilcox;Akbar S. Khan;Akbar S. Khan;Janet A. Hopkins;James M. Sikela;James M. Sikela

  • Chronic Ethanol Treatment Alters Brain Levels of γ‐Aminobutyric AcidA Receptor Subunit mRNAs: Relationship to Genetic Differences in Ethanol Withdrawal Seizure Severity

    Kari J. Buck;Lisa Hahner;James Sikela;James Sikela;R. Adron Harris

  • DUF1220-domain copy number implicated in human brain-size pathology and evolution.

    Laura J. Dumas;Majesta S. O’Bleness;Jonathan M. Davis;Jonathan M. Davis;C. Michael Dickens

  • A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor genes on the distal region of the long arm of chromosome 5.

    J.A. Warrington;S.K. Bailey;E. Armstrong;O. Aprelikova

Frequent Co-Authors

Thomas E. Johnson
Thomas E. Johnson University of Colorado Boulder
Jonathan R. Pollack
Jonathan R. Pollack Stanford University
Mihael H. Polymeropoulos
Mihael H. Polymeropoulos Vanda Pharmaceuticals (United States)
Charles Auffray
Charles Auffray Centre national de la recherche scientifique, CNRS
Marc Lalande
Marc Lalande University of Connecticut Health Center
R. Adron Harris
R. Adron Harris The University of Texas at Austin
Paul J. Whiting
Paul J. Whiting University College London
Thomas J. Hudson
Thomas J. Hudson Ontario Institute for Cancer Research
Evan E. Eichler
Evan E. Eichler University of Washington
Richard K. Wilson
Richard K. Wilson Nationwide Children's Hospital

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