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Biology and Biochemistry

D-Index
63
Citations
14359
World Ranking
10213
National Ranking
4458

Overview

Paula L. Hoffman is affiliated with the University of Colorado Anschutz Medical Campus in the United States. Their research primarily focuses on the intersections of biochemistry, genetics, and molecular biology, with significant contributions also in the field of medicine. Within these broader fields, Hoffman has explored subfields such as molecular biology, physiology, cancer research, oncology, and biochemistry.

Their work encompasses various topics, notably RNA research and splicing, cancer-related molecular mechanisms research, RNA modifications and cancer, peroxisome proliferator-activated receptors, cytokine signaling pathways and interactions, eicosanoids and hypertension pharmacology, and receptor mechanisms and signaling.

Hoffman's recent papers include the following publications:

  • A long non-coding RNA (Lrap) modulates brain gene expression and levels of alcohol consumption in rats, 2020, Genes Brain & Behavior
  • Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel, 2022, Frontiers in Genetics
  • The role of the type 7 adenylyl cyclase isoform in alcohol use disorder and depression, 2022, Frontiers in Pharmacology
  • Controlling the "Opioid Epidemic": A Novel Chemical Entity (NCE) to Reduce or Supplant Opiate Use for Chronic Pain, 2020, Journal of Psychiatry and Brain Science
  • Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder, 2021, Alcoholism Clinical and Experimental Research

Frequent coauthors collaborating with Hoffman include:

  • Boris Tabakoff
  • Laura Saba
  • Spencer Mahaffey
  • Gregg E. Homanics
  • Swapna Vidhur Daulatabad

Hoffman's publications have appeared in multiple specialized venues such as:

  • Genes Brain & Behavior
  • Frontiers in Genetics
  • Frontiers in Pharmacology
  • Journal of Psychiatry and Brain Science
  • Alcoholism Clinical and Experimental Research

Best Publications

  • Effects of Moderate Alcohol Consumption on the Central Nervous System

    Michael J. Eckardt;Sandra E. File;Gian Luigi Gessa;Kathleen A. Grant

  • N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP Production

    Paula L. Hoffman;Carolyn S. Rabe;Frances Moses;Boris Tabakoff

  • The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations

    Yuanbin Ru;Katerina J. Kechris;Boris Tabakoff;Paula Hoffman

  • Brain regional specificity and time-course of changes in the NMDA receptor-ionophore complex during ethanol withdrawal

    Karoly Gulya;Kathleen A. Grant;Peter Valverius;Paula L. Hoffman

  • Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis.

    Megan K. Mulligan;Igor Ponomarev;Robert J. Hitzemann;John K. Belknap

  • Differences in Platelet Enzyme Activity between Alcoholics and Nonalcoholics

    B Tabakoff;P L Hoffman;J M Lee;T Saito

  • Brain-Derived Neurotrophic Factor Mediates the Anti-Apoptotic Effect of NMDA in Cerebellar Granule Neurons: Signal Transduction Cascades and Site of Ethanol Action

    Sanjiv V. Bhave;Lucy Ghoda;Paula L. Hoffman

  • Ethanol and guanine nucleotide binding proteins: a selective interaction.

    Paula L. Hoffman;Boris Tabakoff

  • Chronic ethanol ingestion decreases vasopressin mRNA in hypothalamic and extrahypothalamic nuclei of mouse brain

    Karoly Gulya;Jitendra R. Dave;Paula L. Hoffman

  • Chronic exposure of cerebellar granule cells to ethanol results in increased N-methyl-D-aspartate receptor function.

    K R Iorio;L Reinlib;B Tabakoff;P L Hoffman

  • Regional and subunit specific changes in NMDA receptor mRNA and immunoreactivity in mouse brain following chronic ethanol ingestion.

    Lawrence D. Snell;Karin R. Nunley;Ronald L. Lickteig;Michael D. Browning

  • Neurohypophyseal hormones, analogs, and fragments: their effect on puromycin-induced amnesia.

    Roderich Walter;P. L. Hoffman;Josefa B. Flexner;Louis B. Flexner

  • Radioligand binding to the N-methyl-D-aspartate receptor/ionophore complex: alterations by ethanol in vitro and by chronic in vivo ethanol ingestion.

    Lawrence D. Snell;Boris Tabakoff;Paula L. Hoffman

  • Ethanol and the NMDA receptor.

    Paula L. Hoffman;Carolyn S. Rabe;Kathleen A. Grant;Peter Valverius

  • Ethanol Promotes Apoptosis in Cerebellar Granule Cells by Inhibiting the Trophic Effect of NMDA

    Sanjiv V. Bhave;Paula L. Hoffman

  • Genetical genomic determinants of alcohol consumption in rats and humans

    Boris Tabakoff;Laura Saba;Morton Printz;Pam Flodman

  • Animal Models in Alcohol Research

    Boris Tabakoff;Paula L. Hoffman

  • Alcohol Addiction: An Enigma among Us

    Boris Tabakoff;Paula L Hoffman

  • The neurobiology of alcohol consumption and alcoholism: an integrative history.

    Boris Tabakoff;Paula L. Hoffman

  • Alcohol interactions with brain opiate receptors

    Boris Tabakoff;Boris Tabakoff;Paula L. Hoffman

Frequent Co-Authors

Boris Tabakoff
Boris Tabakoff University of Colorado Anschutz Medical Campus
Roderich Walter
Roderich Walter University of Illinois at Urbana-Champaign
Kathleen A. Grant
Kathleen A. Grant Oregon National Primate Research Center
George F. Koob
George F. Koob National Institute on Drug Abuse
John Whitfield
John Whitfield QIMR Berghofer Medical Research Institute
Bridget F. Grant
Bridget F. Grant National Institutes of Health
R. Adron Harris
R. Adron Harris The University of Texas at Austin
Michal Pravenec
Michal Pravenec Czech Academy of Sciences
John K. Belknap
John K. Belknap Oregon Health & Science University
Robert W. Williams
Robert W. Williams University of Tennessee Health Science Center

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