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Diane Hollenbaugh

Diane Hollenbaugh

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
12879
World Ranking
16990
National Ranking
7004

Overview

Diane Hollenbaugh is affiliated with Bonum Therapeutics in the United States. Their research spans several interconnected fields, primarily focused on medicine, immunology, and oncology. The scientist has contributed notably to areas including cancer immunotherapy and biomarkers, immunotherapy and immune responses, monoclonal and polyclonal antibodies research, CAR-T cell therapy research, T-cell and B-cell immunology, cytokine signaling pathways and interactions, and immune cell function and interaction.

The scientist has published in various academic venues, including:

  • Nature Cancer
  • Molecular Cancer Therapeutics
  • Cancer Research
  • Regular and Young Investigator Award Abstracts

Recent publications by Diane Hollenbaugh include:

  • "An anti-PD-1-GITR-L bispecific agonist induces GITR clustering-mediated T cell activation for cancer immunotherapy" (2022), published in Nature Cancer
  • "Epitope and Fc-Mediated Cross-linking, but Not High Affinity, Are Critical for Antitumor Activity of CD137 Agonist Antibody with Reduced Liver Toxicity" (2020), published in Molecular Cancer Therapeutics
  • "Abstract 4062: A novel method for generating regulated cytokine therapeutics: Safety and activity of a conditionally active cLAG3-IL2 capable of delivering IL2 to LAG3+ cells while remaining inert on LAG3- cells" (2024), published in Cancer Research
  • "953 Identification of a human IFNα2b variant active in mice and its use in a new class of targeted and conditional IFNα therapeutics" (2024), published in Regular and Young Investigator Award Abstracts

Frequent coauthors working alongside Diane Hollenbaugh are:

  • Sun K. Ho
  • Mien Sho
  • Archana Thakur
  • C.M. Forsyth
  • Mengli Xiong

The primary research subjects connected to the scientist's work include cancer immunotherapy and biomarkers, immunotherapy and immune responses, and the roles of cytokines and cellular immune mechanisms. The multidisciplinary approach focuses on how immune system components and therapeutic antibodies can be harnessed to treat cancer and modulate immune activity.

Best Publications

  • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways.

    Christian P. Larsen;Eric T. Elwood;Diane Z. Alexander;Shannon C. Ritchie

  • Discovery of a Cytokine and Its Receptor by Functional Screening of the Extracellular Proteome

    Haishan Lin;Ernestine Lee;Kevin Hestir;Cindy Leo

  • The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

    Alejandro Aruffo;Alejandro Aruffo;Mary Farrington;Diane Hollenbaugh;Xu Li

  • The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

    D. Hollenbaugh;L.S. Grosmaire;C.D. Kullas;N.J. Chalupny

  • Expression of functional CD40 by vascular endothelial cells.

    Diane Hollenbaugh;Nicole Mischel-Petty;Caroline P. Edwards;Jan C. Simon

  • Identification of hyaluronic acid binding sites in the extracellular domain of CD44

    RJ Peach;D Hollenbaugh;I Stamenkovic;A Aruffo

  • Stimulation of CD40 with purified soluble gp39 induces proinflammatory responses in human monocytes

    P A Kiener;P Moran-Davis;B M Rankin;A F Wahl

  • CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway

    Christian P. Larsen;Diane Z. Alexander;Diane Hollenbaugh;Eric T. Elwood

  • Wiskott-Aldrich Syndrome/X-Linked Thrombocytopenia: WASP Gene Mutations, Protein Expression, and Phenotype

    Qili Zhu;Chiaki Watanabe;Ting Liu;Diane Hollenbaugh

  • CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.

    Mary Farrington;Laura S. Grosmaire;Shigeaki Nonoyama;Susanna H. Fischer

  • Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver

    Mark A. Kay;Leonard Meuse;Allen M. Gown;Peter Linsley

  • Long-term inhibition of murine lupus by brief simultaneous blockade of the B7/CD28 and CD40/gp39 costimulation pathways.

    David I. Daikh;Barbara K. Finck;Barbara K. Finck;Peter S. Linsley;Diane Hollenbaugh

  • Mutations of the CD40 Ligand Gene and Its Effect on CD40 Ligand Expression in Patients With X-Linked Hyper IgM Syndrome

    Kuniaki Seyama;Shigeaki Nonoyama;Ingvild Gangsaas;Diane Hollenbaugh

  • Anti-CD40 therapy extends renal allograft survival in rhesus macaques.

    Thomas C. Pearson;Joel Trambley;Kris Odom;Daniel C. Anderson

  • B cell activation via CD40 is required for specific antibody production by antigen-stimulated human B cells.

    Shigeaki Nonoyama;Diane Hollenbaugh;Alejandro Aruffo;Jeffrey A. Ledbetter

  • Construction of Immunoglobulin Fusion Proteins

    Diane Hollenbaugh;Alejandro Aruffo

  • Prolonged acceptance of concordant and discordant xenografts with combined CD40 and CD28 pathway blockade.

    Eric T. Elwood;Christian P. Larsen;Hong Rae Cho;Matthias Corbascio

  • CD40 IS FUNCTIONALLY EXPRESSED ON HUMAN KERATINOCYTES

    Ralf W. Denfeld;Diane Hollenbaugh;Alexandra Fehrenbach;Johannes M. Weiss

  • LRRC15 is a novel mesenchymal protein and stromal target for antibody-drug conjugates.

    James W. Purcell;Sonia G. Tanlimco;Jonathan Hickson;Melvin Fox

  • Blockade of Nonhormonal Fibroblast Growth Factors by FP-1039 Inhibits Growth of Multiple Types of Cancer

    Thomas C. Harding;Li Long;Servando Palencia;Hongbing Zhang

Frequent Co-Authors

Alejandro Aruffo
Alejandro Aruffo Syngenta (United States)
Jeffrey A. Ledbetter
Jeffrey A. Ledbetter University of Washington
Jürgen Bajorath
Jürgen Bajorath University of Bonn
Peter S. Linsley
Peter S. Linsley Benaroya Research Institute
Christian P. Larsen
Christian P. Larsen Emory University
Hans D. Ochs
Hans D. Ochs University of Washington
Herren Wu
Herren Wu AstraZeneca (United Kingdom)
Thomas C. Pearson
Thomas C. Pearson Emory University
Randolph J. Noelle
Randolph J. Noelle Dartmouth College
Mark A. Kay
Mark A. Kay Stanford University

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