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Randolph J. Noelle

Randolph J. Noelle

D-Index & Metrics

Immunology

D-Index
114
Citations
48910
World Ranking
410
National Ranking
252

Overview

Randolph J. Noelle is affiliated with Dartmouth College in the United States. Their research primarily focuses on the fields of Immunology and Microbiology, with additional work in Medicine. Within these areas, the subfields covered include Immunology, Oncology, Molecular Biology, Pathology and Forensic Medicine, and Neurology.

Their work concentrates on several key topics in the biomedical sciences, including:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Immune cells in cancer
  • CAR-T cell therapy research
  • Cytokine Signaling Pathways and Interactions

Randolph J. Noelle has contributed to numerous publications in various scientific journals. Frequent publication venues include:

  • The Journal of Immunology
  • Frontiers in Immunology
  • Science
  • Frontiers in Oncology
  • Regular and Young Investigator Award Abstracts

Their recent papers include the following:

  • "VISTA is a checkpoint regulator for naïve T cell quiescence and peripheral tolerance," 2020, Science
  • "Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey," 2020, Nature Reviews. Immunology
  • "VISTA: Coming of age as a multi-lineage immune checkpoint," 2020, Clinical & Experimental Immunology
  • "PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype," 2021, PLoS Biology
  • "VISTA Re-programs Macrophage Biology Through the Combined Regulation of Tolerance and Anti-inflammatory Pathways," 2020, Frontiers in Immunology

Collaboration is a notable aspect of their research, with frequent co-authors including:

  • J. Louise Lines
  • Mohamed ElTanbouly
  • Elizabeth C. Nowak
  • Evelien Schaafsma
  • Bruce R. Blazar

Best Publications

  • Molecular mechanism and function of CD40/CD40L engagement in the immune system.

    Raul Elgueta;Micah J. Benson;Victor C. de Vries;Anna Wasiuk

  • Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism

    David C. Gondek;Li-Fan Lu;Sergio A. Quezada;Shimon Sakaguchi

  • BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells

    Brian P. O'Connor;Vanitha S. Raman;Loren D. Erickson;W. James Cook

  • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells

    Randolph J. Noelle;Meenakshi Roy;David M. Shepherd;Ivan Stamenkovic

  • Mice deficient for the CD40 ligand.

    Jianchao Xu;Teresa M. Foy;Jon D. Laman;Eileen A. Elliott

  • Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.

    Melanie Greter;Frank L Heppner;Maria P Lemos;Bernhard M Odermatt

  • All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation

    Micah J. Benson;Karina Pino-Lagos;Mario Rosemblatt;Randolph J. Noelle

  • Visualization of Specific B and T Lymphocyte Interactions in the Lymph Node

    Paul Garside;Elizabeth Ingulli;Rebecca R. Merica;Julia G. Johnson

  • The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

    Alejandro Aruffo;Alejandro Aruffo;Mary Farrington;Diane Hollenbaugh;Xu Li

  • Mast cells are essential intermediaries in regulatory T-cell tolerance.

    Li Fan Lu;Evan F. Lind;David C. Gondek;Kathy A. Bennett

  • CD40/CD154 interactions at the interface of tolerance and immunity

    Sergio A. Quezada;Lamis Z. Jarvinen;Evan F. Lind;Randolph J. Noelle

  • VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

    Li-Li Wang;Rotem Rubinstein;Janet L. Lines;Anna Wasiuk

  • IMMUNE REGULATION BY CD40 AND ITS LIGAND GP39

    Teresa M. Foy;Alejandro Aruffo;Jürgen Bajorath;Janet E. Buhlmann

  • Prevention of collagen-induced arthritis with an antibody to gp39, the ligand for CD40

    Fiona H. Durie;Roy A. Fava;Teresa M. Foy;Alejandro Aruffo

  • CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis

    Koen Gerritse;Jon D. Laman;Randolph J. Noelle;Alejandro Aruffo

  • Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade

    Patricia A. Taylor;Randolph J. Noelle;Bruce R. Blazar

  • gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory.

    Teresa M. Foy;Jon D. Laman;Jeffrey A. Ledbetter;Alejandro Aruffo

  • Increased expression of Ia antigens on resting B cells: an additional role for B-cell growth factor.

    Randolph Noelle;Peter H. Krammer;Junichi Ohara;Jonathan W. Uhr

  • Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12.

    Burkhard Becher;Brigit G. Durell;Randolph J. Noelle

  • VISTA Regulates the Development of Protective Antitumor Immunity.

    Isabelle Le Mercier;Wenna Chen;Janet L Lines;Maria Day

  • In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. II. Prolonged suppression of the humoral immune response by an antibody to the ligand for CD40, gp39.

    Teresa M. Foy;David M. Shepherd;Fiona H. Durie;Alejandro Aruffo

Frequent Co-Authors

Alejandro Aruffo
Alejandro Aruffo Syngenta (United States)
Bruce R. Blazar
Bruce R. Blazar University of Minnesota
Jeffrey A. Ledbetter
Jeffrey A. Ledbetter University of Washington
Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Sergio A. Quezada
Sergio A. Quezada University College London
Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Patricia A. Taylor
Patricia A. Taylor University of Minnesota
John P. Mordes
John P. Mordes University of Massachusetts Chan Medical School
Angela Panoskaltsis-Mortari
Angela Panoskaltsis-Mortari University of Minnesota
Graham M. Lord
Graham M. Lord University of Manchester

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