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Immunology

D-Index
62
Citations
12227
World Ranking
3159
National Ranking
1482

Overview

John P. Mordes is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, as well as Immunology and Microbiology. The scientist's work delves deeply into subfields such as Immunology, Genetics, Cell Biology, Molecular Biology, and Gastroenterology.

The main topics explored in Mordes's research include:

  • Diabetes and associated disorders
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Proteoglycans and glycosaminoglycans research
  • Glycosylation and Glycoproteins Research
  • Celiac Disease Research and Management

Mordes has contributed to several publications, with notable recent papers including:

  • "T Cell Receptor Genotype and Ubash3a Determine Susceptibility to Rat Autoimmune Diabetes," 2021, published in Genes
  • "The Vbeta13 T Cell Receptor Monoclonal Antibody Reduces Hyaluronan and CD68+, CD3+, and CD8+ Cell Infiltrations to Delay Diabetes in Congenic BB DRLyp/Lyp Rats," 2021, published in Frontiers in Endocrinology
  • "Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B," 2023, published in bioRxiv (Cold Spring Harbor Laboratory)

The frequent co-authors who have collaborated with Mordes include Elizabeth P. Blankenhorn, Åke Lernmark, Laura Cort, Zhijun Liu, and Ryan Eberwine.

Mordes's research has been featured in multiple venues, including:

  • Genes
  • Frontiers in Endocrinology
  • bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand

    David C. Parker;Dale L. Greiner;Nancy E. Phillips;Michael C. Appel

  • Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4(+) T cells, interferon-gamma, and CTLA4

    Thomas G. Markees;Nancy E. Phillips;Ethel J. Gordon;Randolph J. Noelle

  • Immunology of insulin-dependent diabetes mellitus.

    Aldo A. Rossini;John P. Mordes;Arthur A. Like

  • Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner.

    Neal N. Iwakoshi;John P. Mordes;Thomas G. Markees;Nancy E. Phillips

  • Autoimmune diabetes mellitus in the BB rat.

    Laura Crisá;John P. Mordes;Aldo A. Rossini

  • Rat models of type 1 diabetes: genetics, environment, and autoimmunity.

    John P. Mordes;Rita Bortell;Elizabeth P. Blankenhorn;Aldo A. Rossini

  • Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats.

    D L Greiner;J P Mordes;E S Handler;M Angelillo

  • Allogeneic hematopoietic chimerism in mice treated with sublethal myeloablation and anti-CD154 antibody: absence of graft-versus-host disease, induction of skin allograft tolerance, and prevention of recurrent autoimmunity in islet-allografted NOD/Lt mice

    Edward Seung;Neal N. Iwakoshi;Bruce A. Woda;Thomas G. Markees

  • Prolonged survival of mouse skin allografts in recipients treated with donor splenocytes and antibody to CD40 ligand.

    Thomas G. Markees;Nancy E. Phillips;Randolph J. Noelle;Leonard D. Shultz

  • High Levels of Human Peripheral Blood Mononuclear Cell Engraftment and Enhanced Susceptibility to Human Immunodeficiency Virus Type 1 Infection in NOD/LtSz-scid/scid Mice

    RuthAnn M. Hesselton;Dale L. Greiner;John P. Mordes;Thiruchandurai V. Rajan

  • Absence of the RT-6 T cell subset in diabetes-prone BB/W rats.

    D L Greiner;E S Handler;K Nakano;J P Mordes

  • CTLA4 Signals Are Required to Optimally Induce Allograft Tolerance with Combined Donor-Specific Transfusion and Anti-CD154 Monoclonal Antibody Treatment

    Xin Xiao Zheng;Thomas G. Markees;Wayne W. Hancock;Yongsheng Li

  • Virus-Induced Abrogation of Transplantation Tolerance Induced by Donor-Specific Transfusion and Anti-CD154 Antibody

    Raymond M. Welsh;Thomas G. Markees;Bruce A. Woda;Keith A. Daniels

  • TLR Activation Synergizes with Kilham Rat Virus Infection to Induce Diabetes in BBDR Rats

    Danny Zipris;Egil Lien;Jenny X. Xie;Dale L. Greiner

  • TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts.

    Thomas B. Thornley;Michael A. Brehm;Thomas G. Markees;Leonard D. Shultz

  • Induction of Immunologic Tolerance for Transplantation

    Aldo A. Rossini;Dale L. Greiner;John P. Mordes

  • Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells

    John E. Harris;Kenneth D. Bishop;Nancy E. Phillips;John P. Mordes

  • NOD mice have a generalized defect in their response to transplantation tolerance induction.

    Thomas G. Markees;David V. Serreze;Nancy E. Phillips;Christopher H. Sorli

  • Cytokine gene expression in islets and thyroids of BB rats. IFN-gamma and IL-12p40 mRNA increase with age in both diabetic and insulin-treated nondiabetic BB rats.

    D Zipris;D L Greiner;S Malkani;B Whalen

  • TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat

    Danny Zipris;Egil Lien;Anjali Nair;Jenny X. Xie

Frequent Co-Authors

Dale L. Greiner
Dale L. Greiner University of Massachusetts Chan Medical School
Aldo A. Rossini
Aldo A. Rossini University of Massachusetts Chan Medical School
Randolph J. Noelle
Randolph J. Noelle Dartmouth College
David C. Parker
David C. Parker Oregon Health & Science University
Leonard D. Shultz
Leonard D. Shultz Jackson Laboratory
Åke Lernmark
Åke Lernmark Lund University
Raymond M. Welsh
Raymond M. Welsh University of Massachusetts Chan Medical School
David V. Serreze
David V. Serreze The Jackson Laboratory
Joel Moss
Joel Moss National Institutes of Health
Laurence B. Peterson
Laurence B. Peterson Roche (Switzerland)

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