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Biology and Biochemistry

D-Index
47
Citations
8245
World Ranking
18698
National Ranking
7644

Overview

Leigh A. Knodler is affiliated with Washington State University in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a notable focus on food science, endocrinology, immunology, nutrition and dietetics, and molecular biology at the subfield level.

The scientist's work covers several main topics, including:

  • Salmonella and Campylobacter epidemiology
  • Vibrio bacteria research studies
  • Inflammasome and immune disorders
  • Bacterial genetics and biotechnology
  • Bacteriophages and microbial interactions
  • Escherichia coli research studies
  • Trace elements in health

Leigh A. Knodler has published extensively, with several recent papers highlighting their focus on host-pathogen interactions, intracellular pathogen behavior, and inflammasome activation. Select recent publications include:

  • "Intestinal restriction of Salmonella Typhimurium requires caspase-1 and caspase-11 epithelial intrinsic inflammasomes" (2020, PLoS Pathogens)
  • "Global mapping of Salmonella enterica-host protein-protein interactions during infection" (2021, Cell Host & Microbe)
  • "Intracellular niche-specific profiling reveals transcriptional adaptations required for the cytosolic lifestyle of Salmonella enterica" (2021, PLoS Pathogens)
  • "Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes" (2020, Infection and Immunity)
  • "A Brucella effector modulates the Arf6-Rab8a GTPase cascade to promote intravacuolar replication" (2021, The EMBO Journal)

The scientist frequently collaborates with several other researchers, including:

  • Bruce A. Vallance
  • Amanda L. Haeberle
  • Shauna M. Crowley
  • Joannie M. Allaire
  • Alexander V. Predeus

Leigh A. Knodler's publications are commonly found in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • PLoS Pathogens
  • Infection and Immunity
  • Molecular Microbiology

Best Publications

  • Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.

    Leigh A. Knodler;Leigh A. Knodler;Shauna M. Crowley;Ho Pan Sham;Hyungjun Yang

  • Dissemination of invasive Salmonella via bacterial-induced extrusion of mucosal epithelia

    Leigh A. Knodler;Bruce A. Vallance;Jean Celli;Seth Winfree

  • Brucella intracellular replication requires trafficking through the late endosomal/lysosomal compartment.

    Tregei Starr;Tony W. Ng;Tara D. Wehrly;Leigh A. Knodler

  • The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt.

    Leigh A. Knodler;B. Brett Finlay;Olivia Steele-Mortimer

  • The invasion-associated type III secretion system of Salmonella enterica serovar Typhimurium is necessary for intracellular proliferation and vacuole biogenesis in epithelial cells.

    Olivia Steele-Mortimer;John H Brumell;Leigh A Knodler;Stephane Méresse

  • Salmonella effectors within a single pathogenicity island are differentially expressed and translocated by separate type III secretion systems.

    Leigh A. Knodler;Jean Celli;Wolf-Dietrich Hardt;Bruce A. Vallance

  • Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes.

    Leigh A. Knodler;Bruce A. Vallance;Michael Hensel;Daniela Jäckel

  • Taking possession: biogenesis of the Salmonella-containing vacuole.

    Leigh A. Knodler;Olivia Steele-Mortimer

  • Pathogenic trickery: deception of host cell processes

    Leigh A. Knodler;Jean Celli;B. Brett Finlay

  • Activation of Akt/protein kinase B in epithelial cells by the Salmonella typhimurium effector sigD.

    Olivia Steele-Mortimer;Leigh A. Knodler;Sandra L. Marcus;Michael P. Scheid

  • HilD-mediated transcriptional cross-talk between SPI-1 and SPI-2

    Víctor H. Bustamante;Luary C. Martínez;Francisco J. Santana;Leigh A. Knodler

  • Brucella Modulates Secretory Trafficking via Multiple Type IV Secretion Effector Proteins

    Sebenzile Myeni;Robert Child;Tony W. Ng;John J. Kupko

  • Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice

    Mohammed A. Khan;Caixia Ma;Leigh A. Knodler;Yanet Valdez;Yanet Valdez

  • The Salmonella effector protein PipB2 is a linker for kinesin-1.

    Thomas Henry;Carole Couillault;Patrick Rockenfeller;Emmanuel Boucrot

  • Salmonella trafficking is defined by continuous dynamic interactions with the endolysosomal system.

    Dan Drecktrah;Leigh A. Knodler;Dale Howe;Olivia Steele‐Mortimer

  • Eating the strangers within: host control of intracellular bacteria via xenophagy

    Leigh A. Knodler;Jean Celli

  • Mice Lacking T and B Lymphocytes Develop Transient Colitis and Crypt Hyperplasia yet Suffer Impaired Bacterial Clearance during Citrobacter rodentium Infection

    Bruce A. Vallance;Wanyin Deng;Leigh A. Knodler;B. Brett Finlay

  • Quantitative assessment of cytosolic Salmonella in epithelial cells.

    Leigh A. Knodler;Leigh A. Knodler;Vinod Nair;Olivia Steele-Mortimer

  • Salmonella typhimurium Virulence Genes Are Induced upon Bacterial Invasion into Phagocytic and Nonphagocytic Cells

    Cheryl G. Pfeifer;Sandra L. Marcus;Olivia Steele-Mortimer;Leigh A. Knodler

  • Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells.

    Dan Drecktrah;Seamus Levine-Wilkinson;Tapen Dam;Seth Winfree

Frequent Co-Authors

Olivia Steele-Mortimer
Olivia Steele-Mortimer National Institute of Allergy and Infectious Diseases
Bruce A. Vallance
Bruce A. Vallance University of British Columbia
B. Brett Finlay
B. Brett Finlay University of British Columbia
Jean Celli
Jean Celli Washington State University
Michael R. Edwards
Michael R. Edwards Imperial College London
Frances D. Gillin
Frances D. Gillin University of California, San Diego
L. Garry Adams
L. Garry Adams Texas A&M University
Michael McClelland
Michael McClelland University of California, Irvine
Michael Hensel
Michael Hensel Osnabrück University
John H. Brumell
John H. Brumell University of Toronto

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