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Brian K. Coombes

Brian K. Coombes

D-Index & Metrics

Microbiology

D-Index
57
Citations
10639
World Ranking
3603
National Ranking
105

Overview

Brian K. Coombes is affiliated with McMaster University in Canada, focusing their research primarily in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans several subfields including Molecular Biology, Food Science, Molecular Medicine, Ecology, and Infectious Diseases.

Their research addresses multiple key topics, notably Gut microbiota and health, Antibiotic Resistance in Bacteria, Bacteriophages and microbial interactions, Salmonella and Campylobacter epidemiology, Escherichia coli research studies, RNA and protein synthesis mechanisms, and Probiotics and Fermented Foods.

Coombes has contributed to a number of publications across various venues. Frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory), Journal of the Canadian Association of Gastroenterology, Nature, Infection and Immunity, and Nature Microbiology.

Recent papers authored or co-authored by Coombes include:

  • Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling, 2020, Nature
  • Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii, 2023, Nature Chemical Biology
  • High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli, 2021, Nature Communications
  • Psychological stress impairs IL22-driven protective gut mucosal immunity against colonising pathobionts, 2021, Nature Communications
  • Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae, 2020, Cell Reports

Coombes collaborates frequently with several co-authors, including Aline Fiebig-Comyn, Eric D. Brown, Jakob Magolan, Caressa N. Tsai, and Elena F. Verdú. These collaborations reflect ongoing interdisciplinary work within their research focus.

Best Publications

  • A draft genome of Yersinia pestis from victims of the Black Death

    Kirsten I. Bos;Verena J. Schuenemann;G. Brian Golding;Hernán A. Burbano

  • Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance

    Andrew M. King;Sarah A. Reid-Yu;Wenliang Wang;Dustin T. King

  • Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

    Linda Ejim;Maya A Farha;Shannon B Falconer;Jan Wildenhain

  • Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.

    Jonathan M. Stokes;Craig R. MacNair;Bushra Ilyas;Shawn French

  • Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii

    Unknown

  • Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death

    Verena J. Schuenemann;Kirsten I. Bos;Sharon DeWitte;Sarah Schmedes

  • Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics.

    Craig R. MacNair;Jonathan M. Stokes;Lindsey A. Carfrae;Aline A. Fiebig-Comyn

  • Evolution-guided discovery of antibiotics that inhibit peptidoglycan remodelling.

    Elizabeth J. Culp;Nicholas Waglechner;Wenliang Wang;Aline A. Fiebig-Comyn

  • Expression and secretion of Salmonella pathogenicity island-2 virulence genes in response to acidification exhibit differential requirements of a functional type III secretion apparatus and SsaL.

    Brian K. Coombes;Nat F. Brown;Yanet Valdez;John H. Brumell

  • Molecular Analysis as an Aid To Assess the Public Health Risk of Non-O157 Shiga Toxin-Producing Escherichia coli Strains

    Brian K. Coombes;Brian K. Coombes;Mark E. Wickham;Mariola Mascarenhas;Samantha Gruenheid

  • Analysis of the Contribution of Salmonella Pathogenicity Islands 1 and 2 to Enteric Disease Progression Using a Novel Bovine Ileal Loop Model and a Murine Model of Infectious Enterocolitis

    Brian K. Coombes;Bryan A. Coburn;Andrew A. Potter;Susantha Gomis

  • Muramyl Dipeptide-Based Postbiotics Mitigate Obesity-Induced Insulin Resistance via IRF4

    Joseph F. Cavallari;Morgan D. Fullerton;Brittany M. Duggan;Kevin P. Foley

  • Genome sequence of adherent-invasive Escherichia coli and comparative genomic analysis with other E. coli pathotypes

    John H.E. Nash;Andre Villegas;Andrew M. Kropinski;Renan Aguilar-Valenzuela

  • Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis

    Cherrie-Lee N. Small;Sarah A. Reid-Yu;Joseph B. McPhee;Brian K. Coombes

  • Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine.

    Nat F Brown;Bruce A Vallance;Brian K Coombes;Yanet Valdez

  • Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

    Mark S. Ladinsky;Leandro P. Araujo;Xiao Zhang;John Veltri

  • Identification of MEK- and phosphoinositide 3-kinase-dependent signalling as essential events during Chlamydia pneumoniae invasion of HEp2 cells.

    Brian K. Coombes;James B. Mahony

  • FimH Adhesin of Type 1 Fimbriae Is a Potent Inducer of Innate Antimicrobial Responses Which Requires TLR4 and Type 1 Interferon Signalling

    Ali A. Ashkar;Karen L. Mossman;Brian K. Coombes;Carlton L. Gyles

  • Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection.

    Mark E. Wickham;Claudia Lupp;Mariola Mascarenhas;Alejandra Vazquez

  • Crossing the line: selection and evolution of virulence traits.

    Nat F Brown;Mark E Wickham;Brian K Coombes;B. Brett Finlay

  • Chlamydia pneumoniae infection of human endothelial cells induces proliferation of smooth muscle cells via an endothelial cell-derived soluble factor(s).

    Brian K. Coombes;James B. Mahony

Frequent Co-Authors

B. Brett Finlay
B. Brett Finlay University of British Columbia
James B. Mahony
James B. Mahony McMaster University
Eric D. Brown
Eric D. Brown McMaster University
Mohamed A. Karmali
Mohamed A. Karmali Public Health Agency of Canada
Colin Cooper
Colin Cooper University of East Anglia
Alexei Savchenko
Alexei Savchenko University of Calgary
José L. Puente
José L. Puente National Autonomous University of Mexico
Subash Sad
Subash Sad University of Ottawa
Gerard D. Wright
Gerard D. Wright McMaster University
John H. Brumell
John H. Brumell University of Toronto

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