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Yukihiko Shirayama

Yukihiko Shirayama

D-Index & Metrics

Neuroscience

D-Index
47
Citations
9812
World Ranking
6378
National Ranking
208

Overview

Yukihiko Shirayama is affiliated with Teikyo University in Japan and has contributed extensively to research in neuroscience and medicine, with a particular focus on physiological and psychiatric aspects of brain function and disorders. Their work is situated within subfields including physiology, biological psychiatry, clinical psychology, behavioral neuroscience, and cellular and molecular neuroscience.

Their research encompasses several key topics such as tryptophan and brain disorders, stress responses and cortisol, diet and metabolism studies, treatment of major depression, autism spectrum disorder research, adipose tissue and metabolism, and neurotransmitter receptor influence on behavior.

Shirayama's research output features frequent publications in a variety of peer-reviewed journals, with notable venues including Scientific Reports, Behavioural Brain Research, Pharmacology Biochemistry and Behavior, Translational Psychiatry, and Neuropsychopharmacology Reports.

  • Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1, 2020, Translational Psychiatry
  • Prefrontal cortex infusion of beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, produces antidepressant-like effects in a rodent model of depression, 2020, Neuropsychopharmacology Reports
  • Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model, 2020, Scientific Reports
  • Associations among autistic traits, cognitive and affective empathy, and personality traits in adults with autism spectrum disorder and no intellectual disability, 2022, Scientific Reports
  • Allopregnanolone induces antidepressant-like effects through BDNF-TrkB signaling independent from AMPA receptor activation in a rat learned helplessness model of depression, 2020, Behavioural Brain Research

Collaboration is a significant aspect of Shirayama's career, with frequent co-authors including Kenji Hashimoto, Yasunori Oda, Masaaki Iwata, Katsumasa Muneoka, and Masaomi Iyo. These co-authorships span over multiple publications, reflecting ongoing scientific partnerships in related areas of study.

Best Publications

  • Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

    Yukihiko Shirayama;Andrew C.-H. Chen;Shin Nakagawa;David S. Russell

  • R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects

    Yang C;Shirayama Y;Shirayama Y;Zhang Jc;Ren Q

  • Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect

    Andrew C.-H Chen;Yukihiko Shirayama;Kyung-Ho Shin;Rachael L Neve

  • Correlation between plasma levels of glutamate, alanine and serine with severity of depression.

    Hideaki Mitani;Yukihiko Shirayama;Takeshi Yamada;Kazuhisa Maeda

  • Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects.

    Yukihiko Shirayama;Yukihiko Shirayama;Hisahito Ishida;Masaaki Iwata;Gen-i Hazama

  • Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation

    Ji-chun Zhang;Jin Wu;Yuko Fujita;Wei Yao;Wei Yao;Wei Yao

  • Neurochemistry of the Nucleus Accumbens and its Relevance to Depression and Antidepressant Action in Rodents

    Yukihiko Shirayama;Shigeyuki Chaki

  • Negative Correlation between Brain Glutathione Level and Negative Symptoms in Schizophrenia: A 3T 1H-MRS Study

    Daisuke Matsuzawa;Takayuki Obata;Yukihiko Shirayama;Hiroi Nonaka

  • Beta-hydroxybutyrate, an endogenic NLRP3 inflammasome inhibitor, attenuates stress-induced behavioral and inflammatory responses

    Takehiko Yamanashi;Masaaki Iwata;Naho Kamiya;Kyohei Tsunetomi

  • Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat.

    Yukihiko Shirayama;Hiroshi Mitsushio;Mizuo Takashima;Hironobu Ichikawa

  • Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist.

    Yukihiko Shirayama;Chun Yang;Ji-chun Zhang;Qian Ren

  • High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.

    Masatomo Ishikawa;Kiichi Ishiwata;Kenji Ishii;Yuichi Kimura

  • Plasma levels of homovanillic acid, 5-hydroxyindoleacetic acid and cortisol, and serotonin turnover in depressed patients.

    Hideaki Mitani;Yukihiko Shirayama;Takeshi Yamada;Ryuzou Kawahara

  • Correlation of plasma neurosteroid levels to the severity of negative symptoms in male patients with schizophrenia

    Yukihiko Shirayama;Kenji Hashimoto;Yoshio Suzuki;Teruhiko Higuchi

  • Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.

    Yukihiko Shirayama;Kenji Hashimoto

  • Minocycline attenuates hyperlocomotion and prepulse inhibition deficits in mice after administration of the NMDA receptor antagonist dizocilpine.

    Lin Zhang;Yukihiko Shirayama;Masaomi Iyo;Kenji Hashimoto

  • Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study.

    Yukihiko Shirayama;Takayuki Obata;Daisuke Matsuzawa;Hiroi Nonaka

  • AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.

    Chun Yang;Shizuka Kobayashi;Kazuhito Nakao;Chao Dong

  • Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies

    Chie Shimamoto;Tetsuo Ohnishi;Motoko Maekawa;Akiko Watanabe

  • Regional Differences in Brain-Derived Neurotrophic Factor Levels and Dendritic Spine Density Confer Resilience to Inescapable Stress

    Chun Yang;Chun Yang;Yukihiko Shirayama;Yukihiko Shirayama;Ji-chun Zhang;Ji-chun Zhang;Qian Ren;Qian Ren

  • Short communication Correlation between plasma levels of glutamate, alanine and serine with severity of depression

    Hideaki Mitani;Yukihiko Shirayama;Takeshi Yamada;Kazuhisa Maeda

Frequent Co-Authors

Yoshio Minabe
Yoshio Minabe Kanazawa University
Kiyohisa Takahashi
Kiyohisa Takahashi Shiga University of Medical Science
Morikuni Takigawa
Morikuni Takigawa Kagoshima University
Ronald S. Duman
Ronald S. Duman Yale University
Akira Sawa
Akira Sawa Johns Hopkins University
Nakao Iwata
Nakao Iwata Fujita Health University
Takeo Yoshikawa
Takeo Yoshikawa RIKEN Center for Brain Science
Ichiro Sora
Ichiro Sora Kobe University
Yoshimitsu Fukushima
Yoshimitsu Fukushima Shinshu University
Douglas Blackwood
Douglas Blackwood University of Edinburgh

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