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Biology and Biochemistry

D-Index
55
Citations
12882
World Ranking
14909
National Ranking
104

Overview

Anna-Liisa Levonen is affiliated with the University of Eastern Finland in Finland. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, and Medicine, with particular focus on Molecular Biology and Cancer Research within these areas. The work particularly addresses topics related to genomics, phytochemicals, oxidative stress, and the effects and risks of endocrine disrupting chemicals.

Levonen's recent research contributions include papers published in a range of scientific venues. Notable publications are:

  • The KEAP1-NRF2 pathway: Targets for therapy and role in cancer, 2023, Redox Biology
  • LDL Receptor Regulates the Reverse Transport of Macrophage-Derived Unesterified Cholesterol via Concerted Action of the HDL-LDL Axis, 2020, Circulation Research
  • NRF2 is a key regulator of endothelial microRNA expression under proatherogenic stimuli, 2020, Cardiovascular Research
  • A pan-cancer analysis shows immunoevasive characteristics in NRF2 hyperactive squamous malignancies, 2023, Redox Biology
  • The EDCMET Project: Metabolic Effects of Endocrine Disruptors, 2020, International Journal of Molecular Sciences

Their frequent co-authors include Tommi Patinen, Ashik Jawahar Deen, Jouni Härkönen, Jenni Küblbeck, and Minna U. Kaikkonen.

Levonen's work is regularly published in certain scientific journals and platforms. The most frequent publication venues are:

  • Redox Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Open Research Europe
  • Free Radical Biology and Medicine
  • SSRN Electronic Journal

Their subfields of study encompass Health, Toxicology and Mutagenesis, Immunology, and Physiology. Specific topics Levonen has contributed to include:

  • Genomics, phytochemicals, and oxidative stress
  • Effects and risks of endocrine disrupting chemicals
  • Cancer-related molecular mechanisms research
  • IL-33, ST2, and ILC Pathways
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Lung Cancer Treatments and Mutations

Best Publications

  • The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer.

    Emilia Kansanen;Suvi M. Kuosmanen;Hanna Leinonen;Anna-Liisa Levonen

  • Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

    Antonio Cuadrado;Ana I. Rojo;Geoffrey Wells;John D. Hayes

  • Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products.

    Anna-Liisa Levonen;Aimee Landar;Anup Ramachandran;Erin K. Ceaser

  • Generation and Biological Activities of Oxidized Phospholipids

    Valery N. Bochkov;Olga V. Oskolkova;Konstantin G. Birukov;Anna-Liisa Levonen

  • Mitochondria: regulators of signal transduction by reactive oxygen and nitrogen species.

    Paul S. Brookes;Anna-Liisa Levonen;Sruti Shiva;Paolo Sarti

  • Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

    Katja Kanninen;Riikka Heikkinen;Tarja Malm;Taisia Rolova

  • Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.

    Katja Kanninen;Tarja M. Malm;Henna-Kaisa Jyrkkänen;Gundars Goldsteins

  • Redox regulation of antioxidants, autophagy, and the response to stress: Implications for electrophile therapeutics

    Anna-Liisa Levonen;Bradford G. Hill;Emilia Kansanen;Jianhua Zhang

  • Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids.

    Emilia Kansanen;Henna-Kaisa Jyrkkänen;Anna-Liisa Levonen

  • Human glutamate cysteine ligase gene regulation through the electrophile response element.

    Dale A. Dickinson;Anna-Liisa Levonen;Douglas R. Moellering;Erin K. Arnold

  • Electrophilic Nitro-fatty Acids Activate NRF2 by a KEAP1 Cysteine 151-independent Mechanism

    Emilia Kansanen;Gustavo Bonacci;Francisco J. Schopfer;Suvi M. Kuosmanen

  • Nrf2 Gene Transfer Induces Antioxidant Enzymes and Suppresses Smooth Muscle Cell Growth In Vitro and Reduces Oxidative Stress in Rabbit Aorta In Vivo

    Anna-Liisa Levonen;Matias Inkala;Tommi Heikura;Suvi Jauhiainen

  • KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

    Joost O. Fledderus;Reinier A. Boon;Oscar L. Volger;Hanna Hurttila

  • Mitochondria, nitric oxide, and cardiovascular dysfunction ☆

    Anup Ramachandran;Anna-Liisa Levonen;Paul S. Brookes;Erin Ceaser

  • Biphasic Effects of 15-Deoxy-Δ12,14-Prostaglandin J2 on Glutathione Induction and Apoptosis in Human Endothelial Cells

    Anna-Liisa Levonen;Dale A. Dickinson;Douglas R. Moellering;R. Timothy Mulcahy

  • Role of the Keap1-Nrf2 pathway in cancer.

    Hanna M Leinonen;Emilia Kansanen;Petri Pölönen;Merja Heinäniemi

  • Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: Identification of heat shock response as the major pathway activated by nitro-oleic acid

    Emilia Kansanen;Henna-Kaisa Jyrkkänen;Oscar L. Volger;Hanna Leinonen

  • Nrf2 Regulates Antioxidant Gene Expression Evoked by Oxidized Phospholipids in Endothelial Cells and Murine Arteries In Vivo

    Henna-Kaisa Jyrkkänen;Emilia Kansanen;Matias Inkala;Annukka M. Kivelä

  • Cytoprotection against oxidative stress and the regulation of glutathione synthesis.

    Dale A Dickinson;Douglas R Moellering;Karen E Iles;Rakesh P Patel

  • Antioxidant Gene Therapy for Cardiovascular Disease Current Status and Future Perspectives

    Anna-Liisa Levonen;Elisa Vähäkangas;Jonna K. Koponen;Seppo Ylä-Herttuala

Frequent Co-Authors

Seppo Ylä-Herttuala
Seppo Ylä-Herttuala University of Eastern Finland
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Jari Koistinaho
Jari Koistinaho University of Helsinki
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
Kai Kaarniranta
Kai Kaarniranta University of Eastern Finland
Petri T. Kovanen
Petri T. Kovanen Wihuri Research Institute
Henry Jay Forman
Henry Jay Forman University of Southern California
Young-Mi Go
Young-Mi Go Emory University
Paul S. Brookes
Paul S. Brookes University of Rochester Medical Center
Heikki Tanila
Heikki Tanila University of Eastern Finland

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