World's Best Scientists 2026 revealed!

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Medicine

D-Index
84
Citations
30029
World Ranking
14971
National Ranking
172

Overview

Jari Koistinaho is affiliated with the University of Helsinki in Finland and has established a substantial body of research primarily in neuroscience and related medical fields. Their work spans multiple areas including neurology, physiology, molecular biology, and cellular and molecular neuroscience.

The main fields of study in Koistinaho's research include Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology. Within these fields, they have contributed notably to subfields such as Neurology, Physiology, Molecular Biology, Cellular and Molecular Neuroscience, and Cancer Research.

The primary research topics addressed by Koistinaho encompass:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Tryptophan and brain disorders
  • Neurogenesis and neuroplasticity mechanisms
  • MicroRNA in disease regulation
  • Immune cells in cancer
  • Parkinson's Disease Mechanisms and Treatments

The publication record of Koistinaho includes numerous papers in several frequently encountered venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Neuroinflammation
  • Scientific Reports
  • Cells
  • Zenodo (CERN European Organization for Nuclear Research)

Some recent papers authored or coauthored by Koistinaho are:

  • "Metabolic alterations in Parkinson's disease astrocytes," 2020, Scientific Reports
  • "Microglial amyloid beta clearance is driven by PIEZO1 channels," 2022, Journal of Neuroinflammation
  • "Species-specific metabolic reprogramming in human and mouse microglia during inflammatory pathway induction," 2023, Nature Communications
  • "Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids," 2021, Cells
  • "Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery," 2020, Stem Cell Reports

Throughout their research career, Koistinaho has collaborated frequently with several coauthors, including Šárka Lehtonen, Tarja Malm, Marja Koskuvi, Taisia Rõlova, and Jari Tiihonen. These collaborations represent ongoing efforts in multidisciplinary and cooperative research environments.

Best Publications

  • Neuroinflammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

  • A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window.

    Juha Yrjänheikki;Tiina Tikka;Riitta Keinänen;Gundars Goldsteins

  • Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

    Juha Yrjänheikki;Riitta Keinänen;Milla Pellikka;Tomas Hökfelt

  • Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia.

    Tiina Tikka;Bernd L. Fiebich;Gundars Goldsteins;Riitta Keinänen

  • Minocycline Provides Neuroprotection Against N-Methyl-d-aspartate Neurotoxicity by Inhibiting Microglia

    Tiina M. Tikka;Jari E. Koistinaho

  • Nuclear Factor-κB Contributes to Infarction After Permanent Focal Ischemia

    Antti Nurmi;Perttu J. Lindsberg;Milla Koistinaho;Wen Zhang

  • Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice.

    Tarja M. Malm;Milla Koistinaho;Maria Pärepalo;Tero Vatanen

  • SPREADING DEPRESSION AND FOCAL BRAIN ISCHEMIA INDUCE CYCLOOXYGENASE-2 IN CORTICAL NEURONS THROUGH N-METHYL-D-ASPARTIC ACID-RECEPTORS AND PHOSPHOLIPASE A2

    Susanna Miettinen;Francesca R. Fusco;Juha Yrjänheikki;Riitta Keinänen

  • Astrocytes protect neurons from nitric oxide toxicity by a glutathione-dependent mechanism.

    Yongmei Chen;Nina E. Vartiainen;Weihai Ying;Pak H. Chan

  • PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

    Minna Oksanen;Andrew J. Petersen;Nikolay Naumenko;Katja Puttonen

  • Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

    Katja Kanninen;Riikka Heikkinen;Tarja Malm;Taisia Rolova

  • Role of p38 and p44/42 mitogen‐activated protein kinases in microglia

    Milla Koistinaho;Jari Koistinaho

  • Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.

    Katja Kanninen;Tarja M. Malm;Henna-Kaisa Jyrkkänen;Gundars Goldsteins

  • Improving outcome after stroke: overcoming the translational roadblock.

    Matthias Endres;Britta Engelhardt;Jari Koistinaho;Olle Lindvall

  • Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma

    Mikko O. Hiltunen;Leena Alhonen;Jari Koistinaho;Sanna Myöhänen

  • Induction of 70-kDa heat shock protein and hsp70 mRNA following transient focal cerebral ischemia in the rat.

    Hiroyuki Kinouchi;Frank R. Sharp;Frank R. Sharp;Mary P. Hill;Jari Koistinaho;Jari Koistinaho

  • Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice.

    R. Minkeviciene;J. Ihalainen;T. Malm;O. Matilainen

  • Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210.

    Kati Pulkkinen;Tarja Malm;Mikko Turunen;Jari Koistinaho

  • Exosomes as new diagnostic tools in CNS diseases

    Katja M. Kanninen;Nea Bister;Jari Koistinaho;Tarja Malm

  • Neuroinfl ammation in Alzheimer's disease

    Michael T Heneka;Monica J Carson;Joseph El Khoury;Gary E Landreth

Frequent Co-Authors

Heikki Tanila
Heikki Tanila University of Eastern Finland
Stephen M. Sagar
Stephen M. Sagar University of California, San Francisco
Pak H. Chan
Pak H. Chan Stanford University
Anthony R. White
Anthony R. White QIMR Berghofer Medical Research Institute
Jari Tiihonen
Jari Tiihonen Karolinska Institute
Tomas Hökfelt
Tomas Hökfelt Karolinska Institute
Rashid Giniatullin
Rashid Giniatullin University of Eastern Finland
Frank R. Sharp
Frank R. Sharp University of California, Davis
Seppo Ylä-Herttuala
Seppo Ylä-Herttuala University of Eastern Finland
Denis Vivien
Denis Vivien Université de Caen Normandie

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