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Matthias Merkenschlager

Matthias Merkenschlager

D-Index & Metrics

Molecular Biology

D-Index
71
Citations
23370
World Ranking
1354
National Ranking
102

Overview

Matthias Merkenschlager is affiliated with Imperial College London in the United Kingdom. Their research primarily focuses on the field of Biochemistry, Genetics and Molecular Biology, with a significant emphasis on Molecular Biology and Genetics. They have also contributed to areas related to Plant Science, Public Health, Environmental and Occupational Health, and Immunology.

The scientist's work covers a diverse set of topics, which include:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • RNA Research and Splicing
  • RNA modifications and cancer
  • Genetic Syndromes and Imprinting
  • Plant Molecular Biology Research
  • Genetics and Neurodevelopmental Disorders

Matthias Merkenschlager's recent publications reflect their interests in chromatin structure and gene regulation. Notable papers include:

  • "Chromatin jets define the properties of cohesin-driven in vivo loop extrusion" (2022, Molecular Cell)
  • "The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus" (2021, Nature Communications)
  • "Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin" (2021, Nature Communications)
  • "Identifying proteins bound to native mitotic ESC chromosomes reveals chromatin repressors are important for compaction" (2020, Nature Communications)
  • "Cohesin couples transcriptional bursting probabilities of inducible enhancers and promoters" (2022, Nature Communications)

The scientist frequently publishes in specific venues, including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Research Square (Research Square)
  • Communications Biology
  • Scientific Reports

Collaborations are an integral part of Matthias Merkenschlager's work. Common co-authors include Amanda G. Fisher, Andrew Dimond, Alessandro Sardini, Karen Brown, and Chad Whilding.

Best Publications

  • Chromatin signatures of pluripotent cell lines

    Véronique Azuara;Pascale Perry;Stephan Sauer;Mikhail Spivakov

  • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

    Marc H. G. P. Raaijmakers;Siddhartha Mukherjee;Shangqin Guo;Siyi Zhang

  • Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms

    Vania Parelho;Suzana Hadjur;Mikhail Spivakov;Marion Leleu

  • Association of Transcriptionally Silent Genes with Ikaros Complexes at Centromeric Heterochromatin

    Karen E Brown;Simon S Guest;Stephen T Smale;Kyungmin Hahm

  • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

    Stephan Sauer;Ludovica Bruno;Arnulf Hertweck;David Finlay

  • Dicer Ablation Affects Antibody Diversity and Cell Survival in the B Lymphocyte Lineage

    Sergei B. Koralov;Stefan A. Muljo;Gunther R. Galler;Azra Krek;Azra Krek

  • A role for Dicer in immune regulation.

    Bradley S Cobb;Arnulf Hertweck;James P Smith;Eric D. O'Connor

  • T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer.

    Bradley S Cobb;Tatyana Nesterova;Elizabeth A. Thompson;Arnulf Hertweck

  • Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus

    Suzana Hadjur;Luke M. Williams;Natalie K. Ryan;Bradley S. Cobb

  • Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis.

    Yajaira Suárez;Carlos Fernández-Hernando;Jun Yu;Scott A. Gerber

  • CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation

    Matthias Merkenschlager;Elphège P. Nora

  • Data integration in the era of omics: current and future challenges.

    David Gomez-Cabrero;Imad Abugessaisa;Dieter Maier;Andrew E. Teschendorff

  • Dynamic Repositioning of Genes in the Nucleus of Lymphocytes Preparing for Cell Division

    Karen E Brown;Jonathan Baxter;Daniel Graf;Matthias Merkenschlager

  • Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis

    Shaolin Shi;Liping Yu;Celine Chiu;Yezhou Sun

  • CTCF and cohesin: linking gene regulatory elements with their targets.

    Matthias Merkenschlager;Duncan T. Odom

  • Dicer-dependent pathways regulate chondrocyte proliferation and differentiation

    Tatsuya Kobayashi;Jun Lu;Bradley S. Cobb;Stephen J. Rodda

  • MicroRNA miR-125a controls hematopoietic stem cell number

    Shangqin Guo;Jun Lu;Rita Schlanger;Hao Zhang

  • Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation.

    Matthias Merkenschlager;Linda Terry;Robert Edwards;Peter C. L. Beverley

  • Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments

    Vlad C. Seitan;Andre J. Faure;Ye Zhan;Rachel Patton McCord

  • Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus

    Ruth R. E. Williams;Véronique Azuara;Pascale Perry;Stephan Sauer

Frequent Co-Authors

Amanda G. Fisher
Amanda G. Fisher University of Oxford
Jesper Tegnér
Jesper Tegnér King Abdullah University of Science and Technology
Thomas L. Carroll
Thomas L. Carroll Rockefeller University
Boris Lenhard
Boris Lenhard Imperial College London
Stephen T. Smale
Stephen T. Smale University of California, Los Angeles
Ana Conesa
Ana Conesa University of Florida
Neil Brockdorff
Neil Brockdorff University of Oxford
Tatyana B. Nesterova
Tatyana B. Nesterova University of Oxford
Johan A. Westerhuis
Johan A. Westerhuis University of Amsterdam
Brian Hendrich
Brian Hendrich University of Cambridge

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