World's Best Scientists 2026 revealed!
Michael S. Krangel

Michael S. Krangel

D-Index & Metrics

Molecular Biology

D-Index
64
Citations
14271
World Ranking
1746
National Ranking
876

Research.com Recognitions

  • 2012 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Michael S. Krangel is affiliated with Duke University in the United States. Their research primarily focuses on immunology and molecular biology, particularly in the areas of T-cell and B-cell immunology, immune cell function and interaction, and genomics and chromatin dynamics.

The scientist has contributed to several research topics, including:

  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Genomics and Chromatin Dynamics
  • RNA and protein synthesis mechanisms
  • Single-cell and spatial transcriptomics
  • NF-κB Signaling Pathways
  • CRISPR and Genetic Engineering

Michael S. Krangel's publication record includes multiple papers in leading journals, with recent papers covering aspects of thymic differentiation, chromatin organization, and T-cell receptor diversity. Notable recent publications include:

  • The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus, 2021, Nature Communications
  • A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus, 2020, Nucleic Acids Research
  • Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire, 2021, The Journal of Experimental Medicine
  • RORγt up-regulates RAG gene expression in DP thymocytes to expand the Tcra repertoire, 2024, Science Immunology
  • E protein binding at the Tcra enhancer promotes Tcra repertoire diversity, 2023, Frontiers in Immunology

The scientist frequently collaborates with other researchers, including Danielle J. Dauphars, Abani Kanta Naik, Ariana Mihai, Yuan Zhuang, and Mohammad M. Karimi. These co-authors have contributed multiple times across various studies.

Michael S. Krangel's work has been published in venues such as:

  • The Journal of Experimental Medicine
  • Nature Communications
  • Nucleic Acids Research
  • Science Immunology
  • Frontiers in Immunology

The main fields of study under which they have published include Biochemistry, Genetics and Molecular Biology as well as Immunology and Microbiology. Subfields represented within their publications comprise Immunology, Molecular Biology, Plant Science, Cancer Research, and Nutrition and Dietetics.

In 2012, Michael S. Krangel was named a Fellow of the American Association for the Advancement of Science (AAAS).

Best Publications

  • Identification of a putative second T-cell receptor.

    Michael B. Brenner;Michael B. Brenner;Joanne McLean;Deno P. Dialynas;Jack L. Strominger

  • Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.

    Miller;Krangel

  • Two forms of the T-cell receptor gamma protein found on peripheral blood cytotoxic T lymphocytes.

    Michael B. Brenner;Michael B. Brenner;Joanne McLean;Harriet Scheft;Janice Riberdy

  • Assembly and maturation of HLA-A and HLA-B antigens in vivo

    Michael S. Krangel;Harry T. Orr;Jack L. Strominger

  • A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

    Michelle Taylor McMurry;Michael S. Krangel

  • Immunochemical proof that a novel rearranging gene encodes the T cell receptor delta subunit.

    Hochstenbach F;McLean J;Hata S

  • Mechanics of T cell receptor gene rearrangement.

    Michael S Krangel

  • The γδT Cell Receptor

    Michael B. Brenner;Michael B. Brenner;Jack L. Strominger;Michael S. Krangel

  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation

    Vlad C Seitan;Bingtao Hao;Kikuë Tachibana-Konwalski;Thais Lavagnolli

  • Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.

    Jian Guo;Abbas Hawwari;Hong Li;Zuoming Sun

  • Secretion of HLA-A and -B antigens via an alternative RNA splicing pathway.

    Michael S. Krangel

  • Endocytosis and recycling of the T3-T cell receptor complex. The role of T3 phosphorylation.

    Michael S. Krangel

  • Identification of putative human T cell receptor delta complementary DNA clones

    Shingo Hata;Michael B. Brenner;Michael B. Brenner;Michael S> Krangel

  • Gene segment selection in V(D)J recombination: accessibility and beyond

    Michael S Krangel

  • Regulation of T cell receptor-alpha gene recombination by transcription.

    Iratxe Abarrategui;Michael S Krangel

  • The human cytokine I-309 is a monocyte chemoattractant

    Michael D. Miller;Michael S. Krangel

  • Regulation of the T-cell receptor delta enhancer by functional cooperation between c-Myb and core-binding factors.

    C Hernandez-Munain;M S Krangel

  • Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds.

    J F Kaufman;M S Krangel;J L Strominger

  • Chemokines have diverse abilities to form solid phase gradients.

    Dhavalkumar D. Patel;Witte Koopmann;Toshio Imai;Leona P. Whichard

  • A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.

    M S Krangel;H Yssel;C Brocklehurst;H Spits

Frequent Co-Authors

Michael B. Brenner
Michael B. Brenner Harvard Medical School
Jack L. Strominger
Jack L. Strominger Harvard University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University
Barry P. Sleckman
Barry P. Sleckman University of Alabama at Birmingham
Frederick W. Alt
Frederick W. Alt Boston Children's Hospital
Juan Miguel Redondo
Juan Miguel Redondo Spanish National Centre for Cardiovascular Research
Craig H. Bassing
Craig H. Bassing Children's Hospital of Philadelphia
Hamid Band
Hamid Band University of Nebraska Medical Center
David G. Schatz
David G. Schatz Yale University
Matthias Merkenschlager
Matthias Merkenschlager Imperial College London

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring alternative or supplementary fields can expand your career options outside of molecular biology. Many students interested in science-driven careers also consider programs in health, education, or information sciences.

For example, if you have an interest in patient care, online accelerated bsn programs for non nurses provide a fast track into nursing, even for those with bachelor’s degrees in unrelated majors. If you’re interested in supporting individuals with communication challenges, you might look into asha accredited slpa programs or transition through slp bridge programs to qualify for speech-language pathology roles.

Additionally, scientific graduates often thrive in information management or research settings. If you’re drawn to organizing and analyzing scientific information, a library science degree can be a valuable asset for positions in research libraries, biotech firms, or academic institutions.

Best Scientists Citing Michael S. Krangel

Trending Scientists