World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
135
Citations
75504
World Ranking
191
National Ranking
124

Medicine

D-Index
135
Citations
75553
World Ranking
2053
National Ranking
1162

Research.com Recognitions

  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Member of the National Academy of Sciences

Overview

Michael B. Brenner is affiliated with Harvard Medical School in the United States. Their research spans across several fields including Medicine and Immunology and Microbiology, with a particular focus on subfields such as Immunology, Rheumatology, Molecular Biology, Oncology, and Nephrology.

Their main research topics include:

  • Immune Cell Function and Interaction
  • Systemic Lupus Erythematosus Research
  • T-cell and B-cell Immunology
  • Immune cells in cancer
  • Single-cell and spatial transcriptomics
  • Rheumatoid Arthritis Research and Therapies
  • Cytokine Signaling Pathways and Interactions

Michael B. Brenner has contributed to several recent papers, including:

  • Fibroblasts as immune regulators in infection, inflammation and cancer, 2021, Nature reviews. Immunology
  • Notch signalling drives synovial fibroblast identity and arthritis pathology, 2020, Nature
  • Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes, 2023, Nature
  • IL-1-driven stromal-neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies, 2021, Nature Medicine
  • Granzyme K + CD8 T cells form a core population in inflamed human tissue, 2022, Science Translational Medicine

Frequent co-authors collaborating with Michael B. Brenner include:

  • Soumya Raychaudhuri
  • Deepak A. Rao
  • Jennifer H. Anolik
  • A. Helena Jonsson
  • Laura T. Donlin

Their publications have appeared in several notable venues, with multiple contributions in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nature Communications
  • Annals of the Rheumatic Diseases
  • Journal of Clinical Investigation

The scientist has been recognized with honors including Fellow of the American Association for the Advancement of Science (AAAS) in 2008 and Member of the National Academy of Sciences in 2007.

Best Publications

  • Fast, sensitive and accurate integration of single-cell data with Harmony.

    Ilya Korsunsky;Nghia Millard;Jean Fan;Kamil Slowikowski

  • Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin.

    Karyn L. Cepek;Sunil K. Shaw;Sunil K. Shaw;Christina M. Parker;Gary J. Russell

  • Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry.

    Fan Zhang;Kevin Wei;Kamil Slowikowski;Chamith Y Fonseka

  • Natural and synthetic non-peptide antigens recognized by human γδ T cells

    Tanaka Y;Morita Ct;Nieves E;Brenner Mb

  • Identification of a putative second T-cell receptor.

    Michael B. Brenner;Michael B. Brenner;Joanne McLean;Deno P. Dialynas;Jack L. Strominger

  • CD1: antigen presentation and T cell function.

    Manfred Brigl;Michael B. Brenner

  • Recognition of a lipid antigen by CD1-restricted αβ+ T cells

    Evan M. Beckman;Steven A. Porcelli;Craig T. Morita;Samuel M. Behar

  • M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid Cells

    Nicole van der Wel;David Hava;Diane Houben;Donna Fluitsma

  • Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

    Deepak A. Rao;Michael F. Gurish;Jennifer L. Marshall;Kamil Slowikowski

  • Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

    Steven Porcelli;Courtland E. Yockey;Michael B. Brenner;Steven P. Balk

  • Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

    Patrick J. Brennan;Manfred Brigl;Michael B. Brenner

  • Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

    David M. Lee;Daniel S. Friend;Michael F. Gurish;Christophe Benoist

  • Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining

    Jenny E. Gumperz;Sachiko Miyake;Takashi Yamamura;Michael B. Brenner

  • CD1-restricted T cell recognition of microbial lipoglycan antigens.

    P. A. Sieling;D. Chatterjee;S. A. Porcelli;T. I. Prigozy

  • Distinct fibroblast subsets drive inflammation and damage in arthritis.

    Adam P. Croft;Joana Campos;Kathrin Jansen;Jason D. Turner

  • Arthritis Critically Dependent on Innate Immune System Players

    Hong Ji;Koichiro Ohmura;Koichiro Ohmura;Umar Mahmood;David M Lee

  • Mechanism of CD1d-restricted natural killer T cell activation during microbial infection

    Manfred Brigl;Lynn Bry;Sally C Kent;Jenny E Gumperz

  • The immune cell landscape in kidneys of patients with lupus nephritis

    Arnon Arazi;Deepak A Rao;Celine C Berthier;Anne Davidson

  • Lymphocytes bearing antigen-specific γδ T-cell receptors accumulate in human infectious disease lesions

    Robert. L. Modlin;Claude Pirmez;Florence M. Hofman;Victoria Torigian

  • CD1b restricts the response of human CD4-8- T lymphocytes to a microbial antigen

    Steven Porcelli;Craig T. Morita;Michael B. Brenner

  • Calnexin: a membrane-bound chaperone of the endoplasmic reticulum

    John J.M. Bergeron;Michael B. Brenner;David Y. Thomas;David B. Williams

Frequent Co-Authors

Steven A. Porcelli
Steven A. Porcelli Albert Einstein College of Medicine
Soumya Raychaudhuri
Soumya Raychaudhuri Brigham and Women's Hospital
Gerald F. Watts
Gerald F. Watts University of Western Australia
Craig T. Morita
Craig T. Morita University of Iowa
Gurdyal S. Besra
Gurdyal S. Besra University of Birmingham
Patrick J. Brennan
Patrick J. Brennan Colorado State University
Samuel M. Behar
Samuel M. Behar University of Massachusetts Chan Medical School
Lydia Lynch
Lydia Lynch Brigham and Women's Hospital
Michael S. Krangel
Michael S. Krangel Duke University
Jonathan G. Seidman
Jonathan G. Seidman Harvard University

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