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Immunology

D-Index
75
Citations
19382
World Ranking
1987
National Ranking
973

Overview

Samuel M. Behar is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research primarily focuses on immunology and microbiology, with particular attention to infectious diseases, tuberculosis, immune cell function, and molecular biology. The scientist has contributed extensively to understanding the immune response to Mycobacterium tuberculosis infection, with a focus on T-cell immunology and immune interactions in the context of tuberculosis.

The main fields of study of Samuel M. Behar span:

  • Immunology and Microbiology
  • Medicine

Within these fields, their subfields of study include:

  • Immunology
  • Infectious Diseases
  • Epidemiology
  • Molecular Biology
  • Surgery

Key research topics addressed by their work cover:

  • Tuberculosis Research and Epidemiology
  • Immune Cell Function and Interaction
  • Mycobacterium research and diagnosis
  • T-cell and B-cell Immunology
  • Immune Response and Inflammation
  • Single-cell and spatial transcriptomics
  • Immunotherapy and Immune Responses

Samuel M. Behar has authored multiple peer-reviewed papers, including the following recent publications:

  • Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control, 2022, Immunity
  • CD4 T cell help prevents CD8 T cell exhaustion and promotes control of Mycobacterium tuberculosis infection, 2021, Cell Reports
  • Tissue-resident-like CD4+ T cells secreting IL-17 control Mycobacterium tuberculosis in the human lung, 2021, Journal of Clinical Investigation
  • T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection, 2023, Nature Medicine
  • CD11cHi monocyte-derived macrophages are a major cellular compartment infected by Mycobacterium tuberculosis, 2020, PLoS Pathogens

Frequent co-authors include:

  • Christopher M. Sassetti
  • Shayla Boyce
  • Kelly Cavallo
  • Rocky Lai
  • Sarah K. Nyquist

Samuel M. Behar has published predominantly in specialized journals and platforms such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • The Journal of Immunology
  • OPAL (Open@LaTrobe) (La Trobe University)
  • Cell Reports
  • Journal of Clinical Investigation

Best Publications

  • Recognition of a lipid antigen by CD1-restricted αβ+ T cells

    Evan M. Beckman;Steven A. Porcelli;Craig T. Morita;Samuel M. Behar

  • Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria.

    Yuki Kinjo;Emmanuel Tupin;Douglass Wu;Masakazu Fujio

  • Murine CD1d-restricted T cell recognition of cellular lipids

    Jenny E. Gumperz;Christopher Roy;Anna Makowska;Deirdre Lum

  • Dissemination of Mycobacterium tuberculosis is influenced by host factors and precedes the initiation of T-cell immunity.

    Alissa A. Chackerian;Jennifer M. Alt;Thushara V. Perera;Christopher C. Dascher

  • Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis.

    Samuel M. Behar;Chris C. Dascher;Michael J. Grusby;Chyung-Ru Wang

  • Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis

    Behar Sm;Martin Cj;Booty Mg;Nishimura T

  • Evasion of innate immunity by Mycobacterium tuberculosis : is death an exit strategy?

    Samuel M. Behar;Maziar Divangahi;Maziar Divangahi;Heinz G. Remold

  • Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection

    Bisweswar Nandi;Samuel M. Behar

  • Mycobacterium tuberculosis evades macrophage defenses by inhibiting plasma membrane repair

    Maziar Divangahi;Minjian Chen;Huixian Gan;Danielle Desjardins

  • The Mannose Receptor Delivers Lipoglycan Antigens to Endosomes for Presentation to T Cells by CD1b Molecules

    Theodore I Prigozy;Peter A Sieling;Daniel Clemens;Phoebe L Stewart

  • Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death

    Minjian Chen;Maziar Divangahi;Huixian Gan;Daniel S.J. Shin

  • In search of a new paradigm for protective immunity to TB

    Claudio Nunes-Alves;Matthew G. Booty;Stephen Carpenter;Pushpalatha Jayaraman

  • Tryptophan Biosynthesis Protects Mycobacteria from CD4 T-Cell-Mediated Killing

    Yanjia J. Zhang;Manchi C. Reddy;Thomas R. Ioerger;Alissa C. Rothchild

  • Efferocytosis Is an Innate Antibacterial Mechanism

    Constance J. Martin;Matthew G. Booty;Matthew G. Booty;Tracy R. Rosebrock;Cláudio Nunes-Alves;Cláudio Nunes-Alves

  • Emerging Tim-3 functions in antimicrobial and tumor immunity

    Kaori Sakuishi;Pushpa Jayaraman;Samuel M. Behar;Ana C. Anderson

  • Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

    Maziar Divangahi;Danielle Desjardins;Cláudio Nunes-Alves;Heinz G Remold

  • Inflammatory signaling in human tuberculosis granulomas is spatially organized

    Mohlopheni J. Marakalala;Ravikiran M. Raju;Kirti Sharma;Yanjia J. Zhang

  • IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation.

    Pushpa Jayaraman;Isabel Sada-Ovalle;Tomoyasu Nishimura;Ana C. Anderson

  • Cytoplasmic Tail-Dependent Localization of CD1b Antigen-Presenting Molecules to MIICs

    Masahiko Sugita;Robin M. Jackman;Elly van Donselaar;Samuel M. Behar

  • Tim3 binding to galectin-9 stimulates antimicrobial immunity

    Pushpa Jayaraman;Isabel Sada-Ovalle;Sarah Beladi;Ana C. Anderson

  • CD1c restricts responses of mycobacteria-specific T cells. Evidence for antigen presentation by a second member of the human CD1 family.

    Evan M. Beckman;Agustín Melián;Samuel M. Behar;Peter A. Sieling

  • Innate Invariant NKT Cells Recognize Mycobacterium tuberculosis–Infected Macrophages, Produce Interferon-γ, and Kill Intracellular Bacteria

    Isabel Sada-Ovalle;Asako Chiba;Adaena Gonzales;Michael B. Brenner

Frequent Co-Authors

Michael B. Brenner
Michael B. Brenner Harvard Medical School
Steven A. Porcelli
Steven A. Porcelli Albert Einstein College of Medicine
Christopher M. Sassetti
Christopher M. Sassetti University of Massachusetts Chan Medical School
Maziar Divangahi
Maziar Divangahi McGill University Health Centre
Heinz G. Remold
Heinz G. Remold Brigham and Women's Hospital
Sarah M. Fortune
Sarah M. Fortune Harvard University
Gurdyal S. Besra
Gurdyal S. Besra University of Birmingham
Matthew D. Scharff
Matthew D. Scharff Albert Einstein College of Medicine
Hardy Kornfeld
Hardy Kornfeld University of Massachusetts Chan Medical School
Jenny E. Gumperz
Jenny E. Gumperz University of Wisconsin–Madison

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