What is he best known for?
The fields of study he is best known for:
Matthew D. Scharff mainly focuses on Antibody, Molecular biology, Monoclonal antibody, Biochemistry and Cryptococcus neoformans.
His research integrates issues of Immunohistochemistry, Receptor and Antigen in his study of Antibody.
His research in Molecular biology intersects with topics in Cell culture, Immunoglobulin heavy chain, Somatic hypermutation, Immunoglobulin light chain and Tissue culture.
The various areas that he examines in his Somatic hypermutation study include Gene, Cytidine deaminase, Germinal center and DNA mismatch repair.
His Monoclonal antibody research focuses on Virology and how it relates to Immunoglobulin gene.
His Cryptococcus neoformans research is multidisciplinary, incorporating perspectives in Spleen, Immunology and Passive immunity.
His most cited work include:
- The polypeptides of adenovirus: I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12☆ (741 citations)
- Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase (609 citations)
- A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells. (608 citations)
What are the main themes of his work throughout his whole career to date?
His main research concerns Antibody, Molecular biology, Monoclonal antibody, Genetics and Somatic hypermutation.
His studies deal with areas such as Somatic cell, Antigen and Tissue culture as well as Antibody.
His work deals with themes such as Cell culture, Biochemistry, Gene, Immunoglobulin heavy chain and Immunoglobulin light chain, which intersect with Molecular biology.
His study in Monoclonal antibody is interdisciplinary in nature, drawing from both Cryptococcus neoformans, Microbiology and Virology.
His Somatic hypermutation research incorporates themes from Immunoglobulin class switching, Mutation, Cytidine deaminase, Affinity maturation and DNA mismatch repair.
His Cytidine deaminase research is multidisciplinary, incorporating elements of Germinal center and Activation-induced deaminase.
He most often published in these fields:
- Antibody (47.95%)
- Molecular biology (46.72%)
- Monoclonal antibody (25.82%)
What were the highlights of his more recent work (between 2007-2020)?
- Somatic hypermutation (22.54%)
- Genetics (23.36%)
- Cytidine deaminase (11.89%)
In recent papers he was focusing on the following fields of study:
Matthew D. Scharff focuses on Somatic hypermutation, Genetics, Cytidine deaminase, Immunoglobulin class switching and DNA mismatch repair.
His Somatic hypermutation study is concerned with Antibody in general.
His Cytidine deaminase study combines topics from a wide range of disciplines, such as Activation-induced deaminase and Affinity maturation.
His work carried out in the field of Immunoglobulin class switching brings together such families of science as Molecular biology and Histone, Gene.
His research on Molecular biology also deals with topics like
- Monoclonal antibody which intersects with area such as Virology, Antigen and Polyclonal antibodies,
- In vitro that intertwine with fields like In vivo.
His DNA mismatch repair research includes themes of Neoplastic transformation and Germinal center.
Between 2007 and 2020, his most popular works were:
- The Biochemistry of Somatic Hypermutation (398 citations)
- Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells. (94 citations)
- A requirement for FcγR in antibody-mediated bacterial toxin neutralization (88 citations)
In his most recent research, the most cited papers focused on:
Matthew D. Scharff spends much of his time researching DNA mismatch repair, Cytidine deaminase, Somatic hypermutation, Genetics and Immunoglobulin class switching.
Matthew D. Scharff combines subjects such as Meiosis, Phenotype, Activation-induced deaminase, Mutation frequency and Molecular biology with his study of Cytidine deaminase.
Matthew D. Scharff works mostly in the field of Molecular biology, limiting it down to concerns involving Ubiquitin ligase and, occasionally, DNA damage.
Immunoglobulin class switching is closely attributed to Gene in his study.
His work on Chromatin, Immunoglobulin heavy chain, Acetylation and Antibody Diversity is typically connected to Histone code as part of general Gene study, connecting several disciplines of science.
His DNA repair research includes elements of Mutation, Germinal center and Affinity maturation.
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