2026 Matthew D. Scharff: Immunology Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Immunology	88	1165	1057	617	548	282	29384

Research.com Recognitions

2015 - AAI-BioLegend Herzenberg Award, American Association of Immunologists
1998 - AAI Excellence in Mentoring Award, American Association of Immunologists
1984 - Fellow of the American Academy of Arts and Sciences
1982 - Member of the National Academy of Sciences

Overview

Matthew D. Scharff is affiliated with the Albert Einstein College of Medicine in the United States. Their research primarily spans the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Scharff's work is situated within several specialized subfields including Immunology, Molecular Biology, Pathology and Forensic Medicine, Genetics, and Cancer Research.

The scientist's research covers a range of main topics, such as:

T-cell and B-cell Immunology
Chronic Lymphocytic Leukemia Research
DNA Repair Mechanisms
Genetic factors in colorectal cancer
Cancer Genomics and Diagnostics
Immunodeficiency and Autoimmune Disorders
Lymphoma Diagnosis and Treatment

Frequently publishing in venues such as bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, Frontiers in Immunology, Nucleic Acids Research, and Frontiers in Oncology, Scharff's scientific contributions are diverse and concentrated in immunology and molecular biology.

Some of the recent publications include:

"AID Overlapping and Polη Hotspots Are Key Features of Evolutionary Variation Within the Human Antibody Heavy Chain (IGHV) Genes," 2020, Frontiers in Immunology
"Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes," 2021, Proceedings of the National Academy of Sciences
"Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice," 2022, Nucleic Acids Research
"The role of HIRA-dependent H3.3 deposition and its modifications in the somatic hypermutation of immunoglobulin variable regions," 2021, Proceedings of the National Academy of Sciences
"Post-Transformation IGHV-IGHD-IGHJ Mutations in Chronic Lymphocytic Leukemia B Cells: Implications for Mutational Mechanisms and Impact on Clinical Course," 2021, Frontiers in Oncology

Scharff has collaborated repeatedly with several researchers, most notably Thomas MacCarthy, Nicholas Chiorazzi, Zhi Duan, Yongwei Zhang, and Catherine Tang, reflecting a network of coauthors involved in related fields of study.

Over the course of the career, Scharff has been recognized with awards including the AAI-BioLegend Herzenberg Award and AAI Excellence in Mentoring Award from the American Association of Immunologists. The scientist is also a Fellow of the American Academy of Arts and Sciences and a Member of the National Academy of Sciences, indicating involvement and acknowledgment within high-level scientific communities.

Best Publications

Single amino acid substitution altering antigen-binding specificity

Stuart Rudikoff;Angela M. Giusti;Wendy D. Cook;Matthew D. Scharff

4403
Citations
The polypeptides of adenovirus: I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12☆

Jacob V. Maizel;David O. White;Matthew D. Scharff

1292
Citations
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

Ronda Bransteitter;Phuong Pham;Matthew D. Scharff;Myron F. Goodman

1001
Citations
A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells.

Malcolm L. Gefter;David H. Margulies;Matthew D. Scharff

865
Citations
The Biochemistry of Somatic Hypermutation

Jonathan U. Peled;Fei Li Kuang;Maria D. Iglesias-Ussel;Sergio Roa

609
Citations
Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity

Betty Diamond;Matthew D. Scharff

477
Citations
The generation of antibody diversity through somatic hypermutation and class switch recombination

Ziqiang Li;Caroline J. Woo;Maria D. Iglesias-Ussel;Diana Ronai

464
Citations
Return to the past: the case for antibody-based therapies in infectious diseases.

Arturo Casadevall;Matthew D. Scharff

428
Citations
The role of somatic hypermutation in the generation of antibody diversity

Deborah L. French;Reuven Laskov;Matthew D. Scharff

393
Citations
Characterization of a Murine Monoclonal Antibody to Cryptococcus neoformans Polysaccharide That Is a Candidate for Human Therapeutic Studies

Arturo Casadevall;Wendy Cleare;Marta Feldmesser;Aharona Glatman-Freedman

363
Citations
SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS I. ADAPTATION OF THE MERWIN PLASMA CELL TUMOR-11 TO CULTURE, CLONING, AND CHARACTERIZATION OF GAMMA GLOBULIN SUBUNITS

Reuven Laskov;Matthew D. Scharff

353
Citations
Protective murine monoclonal antibodies to Cryptococcus neoformans.

J Mukherjee;M D Scharff;A Casadevall

345
Citations
Use of monoclonal anti-mouse immunoglobulin to detect mouse antibodies.

Dale E. Yelton;Catherine Desaymard;Matthew D. Scharff

344
Citations
Significant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism

Nadine C. Chien;Victoria A. Roberts;Angela M. Giusti;Matthew D. Scharff

332
Citations
The polypeptides of adenovirus. II. Soluble proteins, cores, top components and the structure of the virion

Jacob V. Maizel;David O. White;Matthew D. Scharff

331
Citations
Cloning of mouse myeloma cells and detection of rare variants.

Philip Coffino;Reuben Baumal;Reuven Laskov;Matthew D. Scharff

330
Citations
Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas.

Alberto Martin;Philip D. Bardwell;Caroline J. Woo;Manxia Fan

326
Citations
Serum therapy revisited: animal models of infection and development of passive antibody therapy.

A Casadevall;M D Scharff

319
Citations
The role of somatic mutation in the pathogenic anti-DNA response

Betty Diamond;Jessica B. Katz;Elahna Paul;Cynthia Aranow

299
Citations
Rapidly labeled, polyribosome-associated RNA having the properties of histone messenger.

Thaddeus W. Borun;Matthew D. Scharff;Elliott Robbins

290
Citations
Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice.

Philip D Bardwell;Caroline J Woo;Kaichun Wei;Ziqiang Li

288
Citations

Frequent Co-Authors

Arturo Casadevall Johns Hopkins University

Winfried Edelmann Albert Einstein College of Medicine

Betty Diamond Feinstein Institute for Medical Research

Kanti R. Rai Hofstra University

Samuel M. Behar University of Massachusetts Chan Medical School

Myron F. Goodman University of Southern California

Deborah L. French Children's Hospital of Philadelphia

Liise Anne Pirofski Albert Einstein College of Medicine

Joseph D. Buxbaum Icahn School of Medicine at Mount Sinai

David H. Margulies National Institutes of Health

External Links

Personal website of Matthew D. Scharff

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