2015 - AAI-BioLegend Herzenberg Award, American Association of Immunologists
1998 - AAI Excellence in Mentoring Award, American Association of Immunologists
1984 - Fellow of the American Academy of Arts and Sciences
1982 - Member of the National Academy of Sciences
Matthew D. Scharff mainly focuses on Antibody, Molecular biology, Monoclonal antibody, Biochemistry and Cryptococcus neoformans. His research integrates issues of Immunohistochemistry, Receptor and Antigen in his study of Antibody. His research in Molecular biology intersects with topics in Cell culture, Immunoglobulin heavy chain, Somatic hypermutation, Immunoglobulin light chain and Tissue culture.
The various areas that he examines in his Somatic hypermutation study include Gene, Cytidine deaminase, Germinal center and DNA mismatch repair. His Monoclonal antibody research focuses on Virology and how it relates to Immunoglobulin gene. His Cryptococcus neoformans research is multidisciplinary, incorporating perspectives in Spleen, Immunology and Passive immunity.
His main research concerns Antibody, Molecular biology, Monoclonal antibody, Genetics and Somatic hypermutation. His studies deal with areas such as Somatic cell, Antigen and Tissue culture as well as Antibody. His work deals with themes such as Cell culture, Biochemistry, Gene, Immunoglobulin heavy chain and Immunoglobulin light chain, which intersect with Molecular biology.
His study in Monoclonal antibody is interdisciplinary in nature, drawing from both Cryptococcus neoformans, Microbiology and Virology. His Somatic hypermutation research incorporates themes from Immunoglobulin class switching, Mutation, Cytidine deaminase, Affinity maturation and DNA mismatch repair. His Cytidine deaminase research is multidisciplinary, incorporating elements of Germinal center and Activation-induced deaminase.
Matthew D. Scharff focuses on Somatic hypermutation, Genetics, Cytidine deaminase, Immunoglobulin class switching and DNA mismatch repair. His Somatic hypermutation study is concerned with Antibody in general. His Cytidine deaminase study combines topics from a wide range of disciplines, such as Activation-induced deaminase and Affinity maturation.
His work carried out in the field of Immunoglobulin class switching brings together such families of science as Molecular biology and Histone, Gene. His research on Molecular biology also deals with topics like
Matthew D. Scharff spends much of his time researching DNA mismatch repair, Cytidine deaminase, Somatic hypermutation, Genetics and Immunoglobulin class switching. Matthew D. Scharff combines subjects such as Meiosis, Phenotype, Activation-induced deaminase, Mutation frequency and Molecular biology with his study of Cytidine deaminase. Matthew D. Scharff works mostly in the field of Molecular biology, limiting it down to concerns involving Ubiquitin ligase and, occasionally, DNA damage.
Immunoglobulin class switching is closely attributed to Gene in his study. His work on Chromatin, Immunoglobulin heavy chain, Acetylation and Antibody Diversity is typically connected to Histone code as part of general Gene study, connecting several disciplines of science. His DNA repair research includes elements of Mutation, Germinal center and Affinity maturation.
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The polypeptides of adenovirus: I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12☆
Jacob V. Maizel;David O. White;Matthew D. Scharff.
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase
Ronda Bransteitter;Phuong Pham;Matthew D. Scharff;Myron F. Goodman.
Proceedings of the National Academy of Sciences of the United States of America (2003)
A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells.
Malcolm L. Gefter;David H. Margulies;Matthew D. Scharff.
Somatic Cell and Molecular Genetics (1977)
The Biochemistry of Somatic Hypermutation
Jonathan U. Peled;Fei Li Kuang;Maria D. Iglesias-Ussel;Sergio Roa.
Annual Review of Immunology (2008)
Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity
Betty Diamond;Matthew D. Scharff.
Proceedings of the National Academy of Sciences of the United States of America (1984)
The generation of antibody diversity through somatic hypermutation and class switch recombination
Ziqiang Li;Caroline J. Woo;Maria D. Iglesias-Ussel;Diana Ronai.
Genes & Development (2004)
Return to the past: the case for antibody-based therapies in infectious diseases.
Arturo Casadevall;Matthew D. Scharff.
Clinical Infectious Diseases (1995)
The role of somatic hypermutation in the generation of antibody diversity
Deborah L. French;Reuven Laskov;Matthew D. Scharff.
Somatic diversification of S107 from an antiphosphocholine to an anti-DNA autoantibody is due to a single base change in its heavy chain variable region.
Angela M. Giusti;Nadine C. Chien;Donald J. Zack;Seung-Uon Shin.
Proceedings of the National Academy of Sciences of the United States of America (1987)
SYNTHESIS, ASSEMBLY, AND SECRETION OF GAMMA GLOBULIN BY MOUSE MYELOMA CELLS I. ADAPTATION OF THE MERWIN PLASMA CELL TUMOR-11 TO CULTURE, CLONING, AND CHARACTERIZATION OF GAMMA GLOBULIN SUBUNITS
Reuven Laskov;Matthew D. Scharff.
Journal of Experimental Medicine (1970)
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