World's Best Scientists 2026 revealed!
Hiroyuki Mizuguchi

Hiroyuki Mizuguchi

D-Index & Metrics

Molecular Biology

D-Index
79
Citations
22186
World Ranking
1039
National Ranking
80

Overview

Hiroyuki Mizuguchi is affiliated with Osaka University in Japan and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their work spans multiple subfields, including molecular biology, genetics, oncology, biomedical engineering, and surgery.

The scientist's research touches on several main topics such as virus-based gene therapy research, 3D printing in biomedical research, pluripotent stem cells research, pancreatic function and diabetes, cancer research and treatments, viral infectious diseases and gene expression in insects, and liver physiology and pathology.

Frequent publication venues for Mizuguchi include Drug Metabolism and Pharmacokinetics, Scientific Reports, Biological and Pharmaceutical Bulletin, PLoS ONE, and Drug Delivery System.

Recent papers authored or co-authored by Mizuguchi include:

  • Adenovirus vector-based vaccine for infectious diseases, 2021, Drug Metabolism and Pharmacokinetics
  • Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody, 2020, Molecular Therapy
  • Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research, 2021, Molecular Therapy - Methods & Clinical Development
  • Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes, 2021, ACS Biomaterials Science & Engineering
  • Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer, 2020, Molecular Therapy - Oncolytics

Mizuguchi has collaborated frequently with several researchers, including:

  • Fuminori Sakurai
  • Kazuo Takayama
  • Yukiko Ueyama-Toba
  • Tomoki Yamashita
  • Jumpei Yokota

Best Publications

  • IRES-Dependent Second Gene Expression Is Significantly Lower Than Cap-Dependent First Gene Expression in a Bicistronic Vector

    Hiroyuki Mizuguchi;Zhili Xu;Akiko Ishii-Watabe;Eriko Uchida

  • Efficient construction of a recombinant adenovirus vector by an improved in vitro ligation method

    Hiroyuki Mizuguchi;Mark A. Kay

  • A simple method for constructing E1- and E1/E4-deleted recombinant adenoviral vectors.

    Hiroyuki Mizuguchi;Mark A. Kay

  • Expression cloning of a cDNA encoding the bovine histamine H1 receptor.

    Masakatsu Yamashita;Hiroyuki Fukui;Kazushige Sugama;Yoshiyuki Horio

  • Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.

    Kenji Uno;Hideki Katagiri;Tetsuya Yamada;Yasushi Ishigaki

  • Quantitative Comparison of Intracellular Trafficking and Nuclear Transcription between Adenoviral and Lipoplex Systems

    Susumu Hama;Hidetaka Akita;Rie Ito;Hiroyuki Mizuguchi

  • 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

    Kazuo Takayama;Kenji Kawabata;Yasuhito Nagamoto;Keisuke Kishimoto

  • A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

    H Mizuguchi;N Koizumi;N Koizumi;T Hosono;N Utoguchi

  • Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction

    Kazuo Takayama;Mitsuru Inamura;Kenji Kawabata;Kazufumi Katayama

  • A novel PPARγ gene therapy to control inflammation associated with inflammatory bowel disease in a murine model

    Kazufumi Katayama;Koichiro Wada;Atsushi Nakajima;Hiroyuki Mizuguchi

  • A Novel Murine Model of Graves’ Hyperthyroidism with Intramuscular Injection of Adenovirus Expressing the Thyrotropin Receptor

    Yuji Nagayama;Masako Kita-Furuyama;Takao Ando;Kazuhiko Nakao

  • Optimization of transcriptional regulatory elements for constructing plasmid vectors.

    Zhi-Li Xu;Hiroyuki Mizuguchi;Akiko Ishii-Watabe;Eriko Uchida

  • Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

    Takahito Nakagawa;Masato Takahashi;Toshinori Ozaki;Ken-ichi Watanabe

  • Targeted Adenovirus Vectors

    Hiroyuki Mizuguchi;Takao Hayakawa

  • In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

    Hiroyuki Kishimoto;Toru Kojima;Yuichi Watanabe;Shunsuke Kagawa

  • Targeted delivery of CX3CL1 to multiple lung tumors by mesenchymal stem cells.

    Hong Xin;Masahiko Kanehira;Hiroyuki Mizuguchi;Takao Hayakawa

  • Targeted delivery of NK4 to multiple lung tumors by bone marrow-derived mesenchymal stem cells

    M Kanehira;H Xin;K Hoshino;M Maemondo

  • Protective mucosal immunity mediated by epithelial CD1d and IL-10

    Torsten Olszak;Joana F. Neves;C. Marie Dowds;Kristi Baker

  • A novel strategy for the enhancement of drug absorption using a claudin modulator.

    Masuo Kondoh;Akane Masuyama;Azusa Takahashi;Nagayoshi Asano

  • Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

    Kazuo Takayama;Yuta Morisaki;Shuichi Kuno;Yasuhito Nagamoto

Frequent Co-Authors

Takao Hayakawa
Takao Hayakawa National Institutes of Health
Shinsaku Nakagawa
Shinsaku Nakagawa Osaka University
Tadanori Mayumi
Tadanori Mayumi Kobe Gakuin University
Naoki Okada
Naoki Okada Osaka University
Toshiyoshi Fujiwara
Toshiyoshi Fujiwara Okayama University
Takuya Fujita
Takuya Fujita Ritsumeikan University
Ken Hirotsu
Ken Hirotsu Osaka Metropolitan University
Hiroyuki Kagamiyama
Hiroyuki Kagamiyama Osaka Medical College
Kosaku Uyeda
Kosaku Uyeda The University of Texas Southwestern Medical Center
Yoshiyuki Horio
Yoshiyuki Horio Sapporo Medical University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

If you’re interested in Molecular Biology, several online degrees and career pathways can help broaden your options or pivot your career. Many related roles—from research librarians to healthcare specialists—now offer flexible online programs. For instance, students curious about library sciences can learn about the average cost of mlis degree us, which is essential for planning education budgets.

Healthcare is another prominent field for Molecular Biology graduates. There are asha approved slp programs online that enable you to become a speech-language pathologist—an in-demand allied health profession. Additionally, if your background isn't in Communication Sciences and Disorders, you can consider transition to SLP master’s for non-CSD majors through structured online bridge programs.

For those drawn to nursing, there are also online bsn programs for non nurses that accommodate career-changers looking to fast-track into nursing. Exploring these options can help you align your Molecular Biology training with a rewarding career across diverse scientific or healthcare landscapes.

Best Scientists Citing Hiroyuki Mizuguchi

Trending Scientists

Recently Published Articles