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Biology and Biochemistry

D-Index
61
Citations
17043
World Ranking
11191
National Ranking
768

Overview

Takuya Fujita is affiliated with Ritsumeikan University in Japan and has contributed extensively to the field of medicine, with a particular focus on pharmaceutical science, molecular biology, oncology, biomedical engineering, and genetics. Their work encompasses diverse topics including 3D printing in biomedical research, drug transport and resistance mechanisms, drug solubility and delivery systems, advanced drug delivery systems, muscle physiology and disorders, pharmacogenetics and drug metabolism, and pharmacological effects and toxicity studies.

Fujita's recent publications demonstrate a wide range of scientific inquiry. Some notable papers include:

  • Numerical analysis of wind-induced natural ventilation for an isolated cubic room with two openings under small mean wind pressure difference, 2022, Building and Environment
  • Bottom-Up Physiologically Based Oral Absorption Modeling of Free Weak Base Drugs, 2020, Pharmaceutics
  • Characterization of P-Glycoprotein Inhibitors for Evaluating the Effect of P-Glycoprotein on the Intestinal Absorption of Drugs, 2021, Pharmaceutics
  • The Impact of Breast Cancer Resistance Protein (BCRP/ABCG2) on Drug Transport Across Caco-2 Cell Monolayers, 2020, Drug Metabolism and Disposition
  • Relevance of Liquid-Liquid Phase Separation of Supersaturated Solution in Oral Absorption of Albendazole from Amorphous Solid Dispersions, 2021, Pharmaceutics

Their collaborative efforts are reflected in frequent partnerships with other researchers such as Rodi Abdalkader, Yusuke Kono, Ryosuke Negoro, Satoshi Konishi, and Yoko Kataoka. These collaborations span a significant number of joint publications, reinforcing interdisciplinary research approaches.

Fujita's research findings have been disseminated through various scientific outlets, predominantly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports
  • Pharmaceutics
  • Biological and Pharmaceutical Bulletin
  • Pharmaceutical Research

The scientist's contributions to pharmaceutical science encompass both fundamental and applied aspects, particularly concerning drug absorption, transport mechanisms across biological membranes, and drug delivery technologies. Their work on drug resistance proteins like P-Glycoprotein and Breast Cancer Resistance Protein (BCRP/ABCG2) offers insights into intestinal absorption and drug transport dynamics.

Fujita's interdisciplinary reach also extends into biomedical engineering and molecular biology, bridging technological advances such as 3D printing with biomedical research, which may support future developments in customized drug delivery systems and therapeutic strategies.

Best Publications

  • Increased oxidative stress in obesity and its impact on metabolic syndrome

    Shigetada Furukawa;Takuya Fujita;Michio Shimabukuro;Masanori Iwaki

  • Effects of Various Protease Inhibitors on the Intestinal Absorption and Degradation of Insulin in Rats

    Akira Yamamoto;Toshio Taniguchi;Kaori Rikyuu;Tomoko Tsuji

  • Disposition characteristics of macromolecules in tumor-bearing mice.

    Yoshinobu Takakura;Takuya Fujita;Mitsuru Hashida;Hitoshi Sezaki

  • Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate

    P Prasad;H Wang;R Kekuda;T Fujita

  • Extra-Renal Elimination of Uric Acid via Intestinal Efflux Transporter BCRP/ABCG2

    Atsushi Hosomi;Takeo Nakanishi;Takuya Fujita;Ikumi Tamai

  • Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats

    Hideyuki Tozaki;Tomokazu Odoriba;Naoki Okada;Takuya Fujita

  • Exon‐Intron Structure, Analysis of Promoter Region, and Chromosomal Localization of the Human Type 1 σ Receptor Gene

    Puttur D Prasad;Hui W. Li;You Jun Fei;Malliga E. Ganapathy

  • Modulation of Intestinal P-Glycoprotein Function by Cremophor EL and Other Surfactants by an In Vitro Diffusion Chamber Method Using the Isolated Rat Intestinal Membranes

    Yasushi Shono;Hisayo Nishihara;Yasuyuki Matsuda;Shiori Furukawa

  • Absorption Characteristics of Chemically Modified‐Insulin Derivatives with Various Fatty Acids in the Small and Large Intestine

    Hiroyuki Asada;Takayuki Douen;Mitsunori Waki;Sayo Adachi

  • Enhanced Permeability of Insulin across the Rat Intestinal Membrane by Various Absorption Enhancers: Their Intestinal Mucosal Toxicity and Absorption‐enhancing Mechanism of n‐Lauryl‐β‐D‐maltopyranoside

    Tomomi Uchiyama;Tetsuo Sugiyama;Ying‐Shu Quan;Atsushi Kotani

  • Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies.

    Qi Shen;Yulian Lin;Takahiro Handa;Masamichi Doi

  • Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives.

    T. Fujita;Makiya Nishikawa;C. Tamaki;Y. Takakura

  • Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate

    Hiroshi Kodaira;Hiroyuki Kusuhara;Takuya Fujita;Junko Ushiki

  • Involvement of transporter recruitment as well as gene expression in the substrate-induced adaptive regulation of amino acid transport system A.

    Ruan Ling;Christy C. Bridges;Mitsuru Sugawara;Takuya Fujita

  • Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats.

    Yulian Lin;Yulian Lin;Qi Shen;Hidemasa Katsumi;Naoki Okada

  • Pharmacokinetic interaction study of sulphasalazine in healthy subjects and the impact of curcumin as an in vivo inhibitor of BCRP.

    Hiroyuki Kusuhara;Hidetoshi Furuie;Akihiro Inano;Akihiro Sunagawa

  • Effectiveness and Toxicity Screening of Various Absorption Enhancers in the Rat Small Intestine: Effects of Absorption Enhancers on the Intestinal Absorption of Phenol Red and the Release of Protein and Phospholipids from the Intestinal Membrane

    Akira Yamamoto;Tomomi Uchiyama;Reiko Nishikawa;Takuya Fujita

  • Creation and X-ray Structure Analysis of the Tumor Necrosis Factor Receptor-1-selective Mutant of a Tumor Necrosis Factor-α Antagonist

    Hiroko Shibata;Yasuo Yoshioka;Akiko Ohkawa;Kyoko Minowa

  • Efficient Antigen Gene Transduction Using Arg-Gly-Asp Fiber-Mutant Adenovirus Vectors Can Potentiate Antitumor Vaccine Efficacy and Maturation of Murine Dendritic Cells

    Naoki Okada;Tomomi Saito;Yasushige Masunaga;Yukiko Tsukada

  • P-glycoprotein Restricts the Penetration of Oseltamivir Across the Blood-Brain Barrier

    Atsushi Ose;Hiroyuki Kusuhara;Kenzo Yamatsugu;Motomu Kanai

Frequent Co-Authors

Naoki Okada
Naoki Okada Osaka University
Yoshinobu Takakura
Yoshinobu Takakura Kyoto University
Shinsaku Nakagawa
Shinsaku Nakagawa Osaka University
Hitoshi Sezaki
Hitoshi Sezaki Kyoto University
Mitsuru Hashida
Mitsuru Hashida Kyoto University
Vadivel Ganapathy
Vadivel Ganapathy Texas Tech University Health Sciences Center
Hiroyuki Mizuguchi
Hiroyuki Mizuguchi Osaka University
Tadanori Mayumi
Tadanori Mayumi Kobe Gakuin University
Frederick H. Leibach
Frederick H. Leibach Augusta University
Takao Hayakawa
Takao Hayakawa National Institutes of Health

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