D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Chemistry D-index 50 Citations 7,261 214 World Ranking 8814 National Ranking 702

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Biochemistry
  • Internal medicine

Hitoshi Sezaki focuses on Pharmacokinetics, Pharmacology, Dextran, Biochemistry and Chromatography. The various areas that he examines in his Pharmacokinetics study include Cerebrospinal fluid, Nasal cavity, Targeted drug delivery, Endocytosis and Distribution. His work carried out in the field of Pharmacology brings together such families of science as Perfusion, Permeation and Pathology.

While working in this field, he studies both Dextran and Conjugate. His Biochemistry research incorporates themes from Biophysics and Sulfaguanidine. His research integrates issues of Small intestine, Intestinal mucosa, Intestinal absorption, Membrane permeability and Organic chemistry in his study of Chromatography.

His most cited work include:

  • Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. (396 citations)
  • Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice (161 citations)
  • Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity. (137 citations)

What are the main themes of his work throughout his whole career to date?

Hitoshi Sezaki mainly investigates Chromatography, Biochemistry, Intestinal absorption, Pharmacology and Pharmacokinetics. His biological study spans a wide range of topics, including Liposome, Absorption, Emulsion, Membrane and Aqueous solution. Hitoshi Sezaki has researched Biochemistry in several fields, including Absorption and Biophysics.

His Intestinal absorption research includes themes of Salicylic acid, Small intestine and Phenol red. His work deals with themes such as Mitomycin C, Gastrointestinal tract and Perfusion, which intersect with Pharmacology. His research investigates the link between Pharmacokinetics and topics such as Nasal cavity that cross with problems in Cerebrospinal fluid.

He most often published in these fields:

  • Chromatography (30.34%)
  • Biochemistry (26.90%)
  • Intestinal absorption (23.45%)

What were the highlights of his more recent work (between 1993-2019)?

  • Pharmacology (22.76%)
  • Intestinal absorption (23.45%)
  • Pharmacokinetics (14.83%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Pharmacology, Intestinal absorption, Pharmacokinetics, Chromatography and Biochemistry. The concepts of his Pharmacology study are interwoven with issues in Mitomycin C, Phenol red and Pathology. The Intestinal absorption study combines topics in areas such as Absorption, Ileum, Small intestine and Permeability.

His Pharmacokinetics research integrates issues from Endocrinology, Drug and Nasal cavity. He interconnects Whole blood, Salicylic acid, Lipophilicity, Saline and Membrane permeability in the investigation of issues within Chromatography. His Biochemistry study integrates concerns from other disciplines, such as Scientific method and Biophysics.

Between 1993 and 2019, his most popular works were:

  • Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells. (396 citations)
  • Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity. (137 citations)
  • Analysis of Drug Permeation Across Caco-2 Monolayer: Implication for Predicting In Vivo Drug Absorption (121 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Biochemistry
  • Internal medicine

Hitoshi Sezaki mainly focuses on Pharmacokinetics, Pharmacology, Chromatography, Intestinal absorption and Cerebrospinal fluid. His biological study spans a wide range of topics, including Whole blood, Stratum corneum and Incubation. His research in the fields of Oral administration and Drug overlaps with other disciplines such as Conjugate.

His work carried out in the field of Chromatography brings together such families of science as Kidney and Saline. His research in Intestinal absorption intersects with topics in Fetal bovine serum, Lipophilicity, Pulmonary surfactant, Membrane permeability and Cholic acid. His studies in Cerebrospinal fluid integrate themes in fields like Anesthesia, Nasal administration, Nose and Nasal cavity.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells.

Shinji Yamashita;Tomoyuki Furubayashi;Makoto Kataoka;Toshiyasu Sakane.
European Journal of Pharmaceutical Sciences (2000)

606 Citations

Disposition and Tumor Localization of Mitomycin C–Dextran Conjugates in Mice

Yoshinobu Takakura;Akira Takagi;Mitsuru Hashida;Hitoshi Sezaki.
Pharmaceutical Research (1987)

244 Citations

Transport of cephalexin to the cerebrospinal fluid directly from the nasal cavity.

Toshiyasu Sakane;Motohiro Akizuki;Masako Yoshida;Shinji Yamashita.
Journal of Pharmacy and Pharmacology (2011)

206 Citations

The transport of a drug to the cerebrospinal fluid directly from the nasal cavity: the relation to the lipophilicity of the drug.

Toshiyasu Sakane;Motohiro Akizuki;Shinji Yamashita;Tanekazu Nadai.
Chemical & Pharmaceutical Bulletin (1991)

188 Citations

In Vitro System to Evaluate Oral Absorption of Poorly Water-Soluble Drugs: Simultaneous Analysis on Dissolution and Permeation of Drugs

Makoto Kataoka;Yoshie Masaoka;Yukako Yamazaki;Toshiyasu Sakane.
Pharmaceutical Research (2003)

179 Citations

Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives.

T. Fujita;Makiya Nishikawa;C. Tamaki;Y. Takakura.
Journal of Pharmacology and Experimental Therapeutics (1992)

169 Citations

Analysis of Drug Permeation Across Caco-2 Monolayer: Implication for Predicting In Vivo Drug Absorption

Shinji Yamashita;Yoshihiro Tanaka;Yoriko Endoh;Yoko Taki.
Pharmaceutical Research (1997)

164 Citations

New and better protocols for a short-term Caco-2 cell culture system

Shinji Yamashita;Keisuke Konishi;Yukako Yamazaki;Yoko Taki.
Journal of Pharmaceutical Sciences (2002)

160 Citations

Structure–Activity Relationship of 1-Alkyl- or 1 -Alkenylazacycloal kanone Derivatives as Percutaneous Penetration Enhancers

Hirokazu Okamoto;Mitsuru Hashida;Hitoshi Sezaki.
Journal of Pharmaceutical Sciences (1988)

156 Citations

Mitomycin C-dextran conjugate: a novel high molecular weight pro-drug of mitomycin C

T Kojima;M Hashida;S Muranishi;H Sezaki.
Journal of Pharmacy and Pharmacology (2011)

147 Citations

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