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Shigeru Kawakami

Shigeru Kawakami

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
10190
World Ranking
12766
National Ranking
880

Overview

Shigeru Kawakami is affiliated with Nagasaki University in Japan and has contributed extensively to the field of biochemistry, genetics, and molecular biology, with a focus on RNA interference and gene delivery. Their research spans molecular biology, genetics, biomedical engineering, immunology, and biomaterials.

Kawakami's recent publications demonstrate a concentration on lipid nanoparticles (LNPs) and mRNA delivery technologies. Notable papers include:

  • Focused ultrasound/microbubbles-assisted BBB opening enhances LNP-mediated mRNA delivery to brain, 2022, Journal of Controlled Release
  • Recent advances in lipid nanoparticles for delivery of nucleic acid, mRNA, and gene editing-based therapeutics, 2022, Drug Metabolism and Pharmacokinetics
  • Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability, 2022, Pharmaceutics
  • Effect of Cholesterol Content of Lipid Composition in mRNA-LNPs on the Protein Expression in the Injected Site and Liver After Local Administration in Mice, 2022, Journal of Pharmaceutical Sciences
  • A turn-on hydrazide oxidative decomposition-based fluorescence probe for highly selective detection of Cu2+ in tap water as well as cell imaging, 2022, Analytica Chimica Acta

The primary research topics covered in Kawakami's work include:

  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Nanoparticle-Based Drug Delivery
  • Virus-based gene therapy research
  • Immunotherapy and Immune Responses
  • Extracellular vesicles in disease
  • Renal and related cancers

Frequent collaborators in Kawakami's research include Hidefumi Mukai, Naoya Kato, Mariko Kamiya, Koki Ogawa, and Maho Kawaguchi.

Kawakami's work has been published primarily in these venues:

  • Pharmaceutics
  • Journal of Pharmaceutical Sciences
  • Drug Delivery
  • Journal of Controlled Release
  • Drug Metabolism and Pharmacokinetics

Their research contributions examine the molecular and physicochemical characteristics of mRNA-lipid nanoparticles and their implications for protein expression and delivery efficacy. This includes investigations into lipid composition, stability under various conditions, and targeted delivery to organs such as the brain and liver.

Best Publications

  • Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes

    S. Kawakami;A. Sato;Makiya Nishikawa;F. Yamashita

  • Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting.

    Takeshi Terada;Mieko Iwai;Shigeru Kawakami;Fumiyoshi Yamashita

  • In vivo gene delivery to the liver using novel galactosylated cationic liposomes.

    Shigeru Kawakami;Shintaro Fumoto;Makiya Nishikawa;Fumiyoshi Yamashita

  • Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver

    Kensuke Morimoto;Makiya Nishikawa;Shigeru Kawakami;Takayuki Nakano

  • Asialoglycoprotein Receptor-Mediated Gene Transfer Using Novel Galactosylated Cationic Liposomes

    Shigeru Kawakami;Fumiyoshi Yamashita;Makiya Nishikawa;Yoshinobu Takakura

  • Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats

    Wassana Wijagkanalan;Shigeru Kawakami;Mitsuko Takenaga;Rie Igarashi

  • Efficient Gene Transfection by Histidine-Modified Chitosan through Enhancement of Endosomal Escape

    Kai-Ling Chang;Yuriko Higuchi;Shigeru Kawakami;Fumiyoshi Yamashita

  • Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationic liposomes in mice.

    Ayumi Sato;Motoki Takagi;Akira Shimamoto;Shigeru Kawakami

  • Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide

    Shigeru Kawakami;Yuriko Higuchi;Mitsuru Hashida

  • Designing Dendrimers for Drug Delivery and Imaging: Pharmacokinetic Considerations

    Wassana Wijagkanalan;Wassana Wijagkanalan;Shigeru Kawakami;Mitsuru Hashida

  • Biodistribution characteristics of mannosylated, fucosylated, and galactosylated liposomes in mice.

    Shigeru Kawakami;Joseph Wong;Ayumi Sato;Yoshiyuki Hattori

  • Strategies for in vivo delivery of siRNAs: recent progress.

    Yuriko Higuchi;Shigeru Kawakami;Mitsuru Hashida

  • PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice.

    Tatsuya Okuda;Shigeru Kawakami;Naomi Akimoto;Takuro Niidome

  • Targeted Delivery Systems of Small Interfering RNA by Systemic Administration

    Shigeru Kawakami;Mitsuru Hashida

  • Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice.

    Yoshiyuki Hattori;Shigeru Kawakami;Sachiko Suzuki;Fumiyoshi Yamashita

  • Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration.

    Tatsuya Okuda;Shigeru Kawakami;Tadahiro Maeie;Takuro Niidome

  • Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite.

    Yasuhiko Hashida;Hironori Tanaka;Shuwen Zhou;Shigeru Kawakami

  • Evaluation of Proinflammatory Cytokine Production Induced by Linear and Branched Polyethylenimine/Plasmid DNA Complexes in Mice

    Shigeru Kawakami;Yoshitaka Ito;Pensri Charoensit;Fumiyoshi Yamashita

  • The role of dioleoylphosphatidylethanolamine (DOPE) in targeted gene delivery with mannosylated cationic liposomes via intravenous route.

    Yoshiyuki Hattori;Sachiko Suzuki;Shigeru Kawakami;Fumiyoshi Yamashita

  • piggyBac transposon-mediated long-term gene expression in mice.

    Hideyuki Nakanishi;Yuriko Higuchi;Shigeru Kawakami;Fumiyoshi Yamashita

Frequent Co-Authors

Mitsuru Hashida
Mitsuru Hashida Kyoto University
Fumiyoshi Yamashita
Fumiyoshi Yamashita Kyoto University
Makiya Nishikawa
Makiya Nishikawa Tokyo University of Science
Makoto Kiso
Makoto Kiso Gifu University
Takuro Niidome
Takuro Niidome Kumamoto University
Yoshiki Katayama
Yoshiki Katayama Kyushu University
Kenichiro Nakashima
Kenichiro Nakashima Nagasaki University
Hideharu Ishida
Hideharu Ishida Gifu University
Tomokazu Umeyama
Tomokazu Umeyama Kyoto University
Takashi Tanaka
Takashi Tanaka Nagasaki University

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