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Hideharu Ishida

Hideharu Ishida

D-Index & Metrics

Chemistry

D-Index
54
Citations
11286
World Ranking
12544
National Ranking
942

Overview

Hideharu Ishida is affiliated with Gifu University in Japan and has an extensive research portfolio primarily focused on biochemistry, genetics, molecular biology, and chemistry. Their work spans molecular biology, organic chemistry, immunology, epidemiology, and physiology, with a particular emphasis on glycosylation and glycoproteins research, carbohydrate chemistry and synthesis, and immune cell function and interaction.

The research topics covered by Ishida include:

  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis
  • Chemical Synthesis and Analysis
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Lipid Membrane Structure and Behavior
  • Sphingolipid Metabolism and Signaling

Ishida's publications have appeared in several notable venues, with frequent contributions to:

  • Carbohydrate Research
  • Journal of Biological Chemistry
  • Glycoconjugate Journal
  • European Journal of Organic Chemistry
  • The Journal of Experimental Medicine

Some of their recent papers include:

  • Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors (2020, The Journal of Experimental Medicine)
  • Homeostatic and pathogenic roles of GM 3 ganglioside molecular species in TLR 4 signaling in obesity (2020, The EMBO Journal)
  • Therapeutic Effect of Neuraminidase-1-Selective Inhibition in Mouse Models of Bleomycin-Induced Pulmonary Inflammation and Fibrosis (2020, Journal of Pharmacology and Experimental Therapeutics)
  • The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells (2021, The Journal of Immunology)
  • Structural insight into the recognition of pathogen-derived phosphoglycolipids by C-type lectin receptor DCAR (2020, Journal of Biological Chemistry)

Ishida collaborates frequently with a group of co-authors, including:

  • Akihiro Imamura
  • Hiromune Ando
  • Naoko Komura
  • Hidenori Tanaka
  • Hiromu Takematsu

Their work collectively addresses complex biological and chemical processes related to glycosylation, immune signaling, and molecular interactions. This interdisciplinary approach reflects the integration of biochemical, genetic, and chemical synthesis methods.

Best Publications

  • Sialic Acid Species as a Determinant of the Host Range of Influenza A Viruses

    Yasuo Suzuki;Toshihiro Ito;Takashi Suzuki;Robert E. Holland

  • IDENTIFICATION OF A MAJOR CARBOHYDRATE CAPPING GROUP OF THE L-SELECTIN LIGAND ON HIGH ENDOTHELIAL VENULES IN HUMAN LYMPH NODES AS 6-SULFO SIALYL LEWIS X

    Chikako Mitsuoka;Mikiko Sawada-Kasugai;Keiko Ando-Furui;Mineko Izawa

  • Molecular Cloning of a Novel α2,3-Sialyltransferase (ST3Gal VI) That Sialylates Type II Lactosamine Structures on Glycoproteins and Glycolipids

    Tetsuya Okajima;Satoshi Fukumoto;Satoshi Fukumoto;Hiroshi Miyazaki;Hideharu Ishida

  • Communication: Synthetic Studies on Sialoglycoconjugates 25: Reactivity of Glycosyl Promoters in α-Glycosylation of N-Acetyl-Neuraminic Acid with the Primary and Secondary Hydroxyl Groups in the Suitably Protected Galactose and Lactose Derivatives

    Akira Hasegawa;Takao Nagahama;Hitoshi Ohki;Kenji Hotta

  • Di-tert-butylsilylene (DTBS) group-directed α-selective galactosylation unaffected by C-2 participating functionalities

    Akihiro Imamura;Hiromune Ando;Satomi Korogi;Genzoh Tanabe

  • Total synthesis of sialyl Lewis X.

    Akihiko Kameyama;Hideharu Ishida;Makoto Kiso;Akira Hasegawa

  • The Crystal Structure of Tetanus Toxin Hc Fragment Complexed with a Synthetic GT1b Analogue Suggests Cross-linking between Ganglioside Receptors and the Toxin

    Constantina Fotinou;Paul Emsley;Isobel Black;Hiromune Ando

  • Characterization of High-Affinity Binding between Gangliosides and Amyloid β-Protein

    Toshio Ariga;Kiyoaki Kobayashi;Akira Hasegawa;Makoto Kiso

  • Recognition of N-Glycolylneuraminic Acid Linked to Galactose by the α2,3 Linkage Is Associated with Intestinal Replication of Influenza A Virus in Ducks

    Toshihiro Ito;Yasuo Suzuki;Takashi Suzuki;Ayato Takada

  • Raft-based interactions of gangliosides with a GPI-anchored receptor

    Naoko Komura;Naoko Komura;Kenichi G N Suzuki;Kenichi G N Suzuki;Hiromune Ando;Hiromune Ando;Miku Konishi;Miku Konishi

  • A facile, large-scale preparation of the methyl 2-thioglycoside of N-acetylneuraminic acid, and its usefulness for the α-stereoselective synthesis of sialoglycosides

    Akira Hasegawa;Hitoshi Ohki;Takao Nagahama;Hideharu Ishida

  • A facile, regio- and stereo-selective synthesis of ganglioside GM3☆

    Takatoshi Murase;Hideharu Ishida;Makoto Kiso;Akira Hasegawa

  • A facile regio- and stereo-selective synthesis of α-glycosides of N-acetylneuraminic acid

    Takatoshi Murase;Hideharu Ishida;Makoto Kiso;Akira Hasegawa

  • Extending the possibility of an N-Troc-protected sialic acid donor toward variant sialo-glycoside synthesis

    Hiromune Ando;Yusuke Koike;Hideharu Ishida;Makoto Kiso

  • Stereoselective synthesis of sialyl-lactotetraosylceramide and sialylneolactotetraosylceramide.

    Akihiko Kameyama;Hideharu Ishida;Makoto Kiso;Akira Hasegawa

  • Synthesis and biological activities of three sulfated sialyl Lex ganglioside analogues for clarifying the real carbohydrate ligand structure of L-selectin

    Shiro Komba;Hideharu Ishida;Makoto Kiso;Akira Hasegawa

  • Synthetic Studies on Sialoglycoconjugates. 5: A Facile, Regio and Stereoselective Synthesis of Ganglioside GM4 and Its Position Isomer1

    Takatoshi Murase;Akihiko Kameyama;K. P. R. Kartha;Hideharu Ishida

  • Synthesis of Disialyl Lewis a (Lea) Structure in Colon Cancer Cell Lines by a Sialyltransferase, ST6GalNAc VI, Responsible for the Synthesis of α-Series Gangliosides

    Akiko Tsuchida;Tetsuya Okajima;Keiko Furukawa;Takayuki Ando

  • Sulfated sialyl Lewis X, the putative L-selectin ligand, detected on endothelial cells of high endothelial venules by a distinct set of anti-sialyl Lewis X antibodies.

    Chikako Mitsuoka;Naoko Kawakami-Kimura;Mikiko Kasugai-Sawada;Nozomu Hiraiwa

  • Sialyl-LewisxSequence 6-O-Sulfated atN-Acetylglucosamine Rather Than at Galactose Is the Preferred Ligand forl-Selectin and De-N-acetylation of the Sialic Acid Enhances the Binding Strength

    Christine Galustian;Alexander M. Lawson;Shiro Komba;Hideharu Ishida

Frequent Co-Authors

Makoto Kiso
Makoto Kiso Gifu University
Akira Hasegawa
Akira Hasegawa Gifu University
Yasuo Suzuki
Yasuo Suzuki Chubu University
Ichiro Azuma
Ichiro Azuma Hokkaido University
Reiji Kannagi
Reiji Kannagi Academia Sinica
Yoshihiro Kawaoka
Yoshihiro Kawaoka University of Tokyo
Takashi Suzuki
Takashi Suzuki University of Shizuoka
Sandro Sonnino
Sandro Sonnino University of Milan
Taeko Miyagi
Taeko Miyagi Tohoku Medical and Pharmaceutical University
Hirofumi Nakano
Hirofumi Nakano Jichi Medical University

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