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Mark von Itzstein

Mark von Itzstein

D-Index & Metrics

Chemistry

D-Index
48
Citations
13428
World Ranking
15050
National Ranking
332

Research.com Recognitions

  • 2015 - Fellow of the Australian Academy of Health and Medical Science
  • 2003 - Fellow of the Australian Academy of Science

Overview

Mark von Itzstein is affiliated with Griffith University in Australia and has an extensive research profile primarily within the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their work spans a variety of subfields including Molecular Biology, Epidemiology, Infectious Diseases, Oncology, and Immunology.

The scientist's research covers a range of topics with a strong focus on Glycosylation and Glycoproteins Research, Respiratory Viral Infections, Viral Gastroenteritis Research and Epidemiology, Pneumonia and Respiratory Infections, Antibiotic Resistance in Bacteria, Peptidase Inhibition and Analysis, and Carbohydrate Chemistry and Synthesis.

Key recent publications by Mark von Itzstein include:

  • Neutralizing the pathological effects of extracellular histones with small polyanions (2020) - Nature Communications
  • Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions (2021) - mBio
  • All major cholesterol-dependent cytolysins use glycans as cellular receptors (2020) - Science Advances
  • Glycosphingolipids are mediators of cancer plasticity through independent signaling pathways (2022) - Cell Reports
  • Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis (2020) - Science Translational Medicine

Their collaborative work frequently involves a core group of co-authors:

  • Michael P. Jennings
  • Arun Everest-Dass
  • Ibrahim M. El-Deeb
  • Patrice Guillon
  • Larissa Dirr

Mark von Itzstein's publications have appeared in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Virology
  • mBio
  • Cell Reports
  • Antimicrobial Agents and Chemotherapy

Recognition of their professional standing includes fellowships in major national academies:

  • Fellow of the Australian Academy of Health and Medical Science (2015)
  • Fellow of the Australian Academy of Science (2003)

Best Publications

  • Rational design of potent sialidase-based inhibitors of influenza virus replication.

    Mark von Itzstein;Wen-Yang Wu;Gaik B. Kok;Michael S. Pegg

  • Unravelling the Role of O-glycans in Influenza A Virus Infection

    Juliane Mayr;Kam Lau;Jimmy C. C. Lai;Ivan A. Gagarinov

  • The war against influenza: discovery and development of sialidase inhibitors.

    Mark von Itzstein

  • NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

    Shane Horsefield;Hayden Burdett;Xiaoxiao Zhang;Xiaoxiao Zhang;Mohammad K. Manik

  • Glycointeractions in bacterial pathogenesis

    Jessica Poole;Christopher J. Day;Mark von Itzstein;James C. Paton

  • Evidence for a sialosyl cation transition-state complex in the reaction of sialidase from influenza virus.

    Andrew K. J. Chong;Michael S. Pegg;Neil R. Taylor;Mark von Itzstein

  • Recent advances in the synthesis of sialic acid derivatives and sialylmimetics as biological probes.

    Milton J. Kiefel;Mark Von Itzstein

  • Limited inhibitory effects of Oseltamivir and Zanamivir on human sialidases

    Keiko Hata;Koichi Koseki;Kazunori Yamaguchi;Setsuko Moriya

  • Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion

    Viatcheslav Zaitsev;Mark von Itzstein;Darrin Groves;Milton Kiefel

  • Molecular Modeling Studies on Ligand Binding to Sialidase from Influenza Virus and the Mechanism of Catalysis

    Unknown

  • Inhibition of sialidases from viral, bacterial and mammalian sources by analogues of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid modified at the C-4 position.

    Cindy T. Holzer;Mark Von Itzstein;Betty Jin;Michael S. Pegg

  • Sialic acid dependence in rotavirus host cell invasion

    Thomas Erwin Haselhorst;Fiona E Fleming;Jeffrey Clifford Dyason;Regan David Hartnell

  • The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor.

    Mark von Itzstein;Wen-Yang Wu;Betty Jin

  • Rapid, clean, and mild O-acetylation of alcohols and carbohydrates in an ionic liquid.

    Stewart A Forsyth;Douglas R MacFarlane;Robin Joy Thomson;Mark von Itzstein

  • Sialic Acid Recognition by Vibrio Cholerae Neuraminidase

    Ibrahim Moustafa;Helen Connaris;Margaret Taylor;Viateslav Zaitsev

  • A study of the active site of influenza virus sialidase: an approach to the rational design of novel anti-influenza drugs.

    Mark von Itzstein;Jeffrey Clifford Dyason;Stuart W. Oliver;Hume F. White

  • Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly.

    Aleksander Hinek;Alexey V. Pshezhetsky;Mark von Itzstein;Barry Starcher

  • Analysis of inhibitor binding in influenza virus neuraminidase.

    Brian J. Smith;Peter M. Colman;Mark Von Itzstein;Basil Danylec

  • Microbial Glycobiology: Structures, Relevance and Applications

    Anthony Patrick Moran;Otto Holst;Patrick J. Brennan;Mark von Itzstein

  • Differential carbohydrate recognition by Campylobacter jejuni strain 11168: influences of temperature and growth conditions.

    Christopher J. Day;Joe Tiralongo;Regan D. Hartnell;Carie-Anne Logue

  • Influenza virus sialidase: effect of calcium on steady-state kinetic parameters.

    Andrew K.J. Chong;Michael S. Pegg;Mark von Itzstein

  • Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles

    Sankar Mohan;Sarah McAtamney;Thomas Erwin Haselhorst;Mark von Itzstein

  • Investigation of the stability of thiosialosides toward hydrolysis by sialidases using NMR spectroscopy.

    Jennifer C. Wilson;Milton J. Kiefel;and Donald I. Angus;Mark von Itzstein

  • A convenient method for the introduction of nitrogen and sulfur at C-4 on a sialic acid analogue

    Mark von Itzstein;Betty Jin;Wen-Yang Wu;Malcolm Chandler

  • Hot, sweet and sticky: the glycobiology of Plasmodium falciparum

    Mark Von Itzstein;Mark Von Itzstein;Magdalena Plebanski;Brian Mark Cooke;Brian Mark Cooke;Ross Leon Coppel;Ross Leon Coppel

  • Lysosomal Sialidase (Neuraminidase-1) Is Targeted to the Cell Surface in a Multiprotein Complex That Facilitates Elastic

    Aleksander Hinek;Alexey V. Pshezhetsky;Mark von Itzstein;Barry Starcher

Frequent Co-Authors

Rita Gerardy-Schahn
Rita Gerardy-Schahn Hannover Medical School
Barbara S. Coulson
Barbara S. Coulson University of Melbourne
Daniel Kolarich
Daniel Kolarich Griffith University
Nicolle H. Packer
Nicolle H. Packer Macquarie University
Michael P. Jennings
Michael P. Jennings Griffith University
Ross L. Coppel
Ross L. Coppel Monash University
Nicholas Farrell
Nicholas Farrell Virginia Commonwealth University
Mark J. Walker
Mark J. Walker University of Queensland
Sylvie van der Werf
Sylvie van der Werf Université Paris Cité
Susan J. Berners-Price
Susan J. Berners-Price Griffith University

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