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Biology and Biochemistry

D-Index
85
Citations
36975
World Ranking
3082
National Ranking
234

Overview

John Bertin is a researcher affiliated with GlaxoSmithKline in the United Kingdom. Their work spans across several primary fields of study including Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these fields, their research focuses on subfields such as Immunology, Molecular Biology, Epidemiology, Surgery, and Infectious Diseases.

Their research addresses several key topics, including:

  • Interferon and immune responses
  • Viral Infections and Vectors
  • Cell death mechanisms and regulation
  • Inflammatory Bowel Disease
  • NF-κB Signaling Pathways
  • Cytokine Signaling Pathways and Interactions
  • Phagocytosis and Immune Regulation

John Bertin has contributed to a range of publications, appearing frequently in journals such as Nature Communications, Nature Metabolism, bioRxiv (Cold Spring Harbor Laboratory), Proceedings of the National Academy of Sciences, and Science Immunology. Notable recent papers include:

  • A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection, 2021, Science Immunology
  • Respiratory Syncytial Virus Infection Promotes Necroptosis and HMGB1 Release by Airway Epithelial Cells, 2020, American Journal of Respiratory and Critical Care Medicine
  • Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance, 2021, Nature Communications
  • Response to Inhibition of Receptor-Interacting Protein Kinase 1 (RIPK1) in Active Plaque Psoriasis: A Randomized Placebo-Controlled Study, 2020, Clinical Pharmacology & Therapeutics
  • An intestinal organoid-based platform that recreates susceptibility to T-cell-mediated tissue injury, 2020, Blood

Collaborations are a significant aspect of their research, with frequent co-authors including Peter J. Gough, Allison M. Beal, Scott B. Berger, Katherine A. Fitzgerald, and Joshi M. Ramanjulu.

Best Publications

  • NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

    Eran Elinav;Till Strowig;Andrew L. Kau;Jorge Henao-Mejia

  • Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan

    Stephen E Girardin;Ivo G Boneca;Leticia A M Carneiro;Aude Antignac

  • Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island

    Jerome Viala;Catherine Chaput;Ivo G Boneca;Ana Cardona

  • Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

    Luigi Franchi;Amal Amer;Mathilde Body-Malapel;Thirumala Devi Kanneganti

  • Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3

    Thirumala Devi Kanneganti;Nesrin Özören;Mathilde Body-Malapel;Amal Amer

  • The NLR gene family: a standard nomenclature

    Jenny P.Y. Ting;Ruth C. Lovering;Emad S. Alnemri;John Bertin

  • Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1

    Fayyaz S. Sutterwala;Yasunori Ogura;Marian Szczepanik;Marian Szczepanik;Maria Lara-Tejero

  • Toll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL

    William J. Kaiser;Haripriya Sridharan;Chunzi Huang;Pratyusha Mandal

  • Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

    Pontus Orning;Pontus Orning;Dan Weng;Dan Weng;Kristian Starheim;Kristian Starheim;Dmitry Ratner

  • MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

    Yves Dondelinger;Wim Declercq;Sylvie Montessuit;Ria Roelandt

  • CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri

    Stephen E. Girardin;Régis Tournebize;Maria Mavris;Anne Laure Page

  • RIP3 induces apoptosis independent of pronecrotic kinase activity.

    Pratyusha Mandal;Scott B. Berger;Sirika Pillay;Kenta Moriwaki

  • Design of amidobenzimidazole STING receptor agonists with systemic activity

    J.M. Ramanjulu;G.S. Pesiridis;J. Yang;N. Concha

  • Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis

    John Bertin;Robert C. Armstrong;Sabine Ottilie;David A. Martin

  • Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis.

    Marietta Zille;Saravanan S. Karuppagounder;Yingxin Chen;Peter J. Gough

  • Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

    John Bertin;Waan-Jeng Nir;Colleen M. Fischer;Olga V. Tayber

  • A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis

    Grace Y. Chen;Maochang Liu;Fuyuan Wang;John Bertin

  • NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens

    Paras K. Anand;R. K. Subbarao Malireddi;John R. Lukens;Peter Vogel

  • PYPAF7, a Novel PYRIN-containing Apaf1-like Protein That Regulates Activation of NF-κB and Caspase-1-dependent Cytokine Processing

    Lin Wang;Gulam A. Manji;Jill M. Grenier;Amal Al-Garawi

  • Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

    Maria Lara-Tejero;Fayyaz S. Sutterwala;Yasunori Ogura;Ethan P. Grant

Frequent Co-Authors

Peter J. Gough
Peter J. Gough Inzen Therapeutics
Dana J. Philpott
Dana J. Philpott University of Toronto
Anthony J. Coyle
Anthony J. Coyle Takeda (United States)
Stephen E. Girardin
Stephen E. Girardin University of Toronto
Peter Vandenabeele
Peter Vandenabeele Ghent University
Edward S. Mocarski
Edward S. Mocarski Emory University
John Silke
John Silke Walter and Eliza Hall Institute of Medical Research
Katherine A. Fitzgerald
Katherine A. Fitzgerald University of Massachusetts Chan Medical School
Michelle A. Kelliher
Michelle A. Kelliher University of Massachusetts Chan Medical School
Ivo G. Boneca
Ivo G. Boneca Institut Pasteur

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