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Microbiology

D-Index
66
Citations
23589
World Ranking
2347
National Ranking
958

Overview

Fayyaz S. Sutterwala is affiliated with Cedars-Sinai Medical Center in the United States and conducts research primarily in the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work focuses extensively on molecular biology, immunology, infectious diseases, epidemiology, and parasitology.

The main areas of research Sutterwala has contributed to include inflammasome and immune disorders, interferon and immune responses, heme oxygenase-1 and carbon monoxide, leptospirosis research and findings, autophagy in disease and therapy, urticaria and related conditions, and viral infections and vectors.

Notable recent publications authored or co-authored by Sutterwala include:

  • Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation (2020, Proceedings of the National Academy of Sciences)
  • Regulation of the NLRP3 inflammasome by autophagy and mitophagy (2024, Immunological Reviews)
  • L-plastin enhances NLRP3 inflammasome assembly and bleomycin-induced lung fibrosis (2022, Cell Reports)
  • A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation (2021, Science Signaling)
  • NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis (2023, iScience)

Frequent co-authors who have collaborated with Sutterwala include:

  • Suzanne L. Cassel
  • Suman Gupta
  • Jargalsaikhan Dagvadorj
  • James Matsunaga
  • David A. Haake

Sutterwala has published multiple works in several scientific journals, with recurrent contributions to:

  • The Journal of Immunology
  • UNC Libraries
  • Immunological Reviews
  • Proceedings of the National Academy of Sciences
  • Cell Reports

The scientist's research contributes to the understanding of inflammasome activation mechanisms, immune regulation by autophagy and mitophagy, and the molecular pathways involved in infectious disease responses. This body of work intersects molecular biology and immunology, providing insights into the cellular processes driving inflammation and immune-mediated diseases.

Best Publications

  • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants.

    Stephanie C. Eisenbarth;Oscar R. Colegio;William O’Connor;Fayyaz S. Sutterwala

  • TLR11 Activation of Dendritic Cells by a Protozoan Profilin-Like Protein

    Felix Yarovinsky;Dekai Zhang;John F. Andersen;Gerard L. Bannenberg

  • Critical role for NALP3/CIAS1/cryopyrin in innate and adaptive immunity through its regulation of caspase-1

    Fayyaz S. Sutterwala;Yasunori Ogura;Marian Szczepanik;Marian Szczepanik;Maria Lara-Tejero

  • The Nalp3 inflammasome is essential for the development of silicosis

    Suzanne L. Cassel;Stephanie C. Eisenbarth;Shankar S. Iyer;Jeffrey J. Sadler

  • Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

    Shankar S. Iyer;Qiong He;John R. Janczy;Eric I. Elliott

  • Initiation and perpetuation of NLRP3 inflammasome activation and assembly

    Eric I. Elliott;Fayyaz S. Sutterwala

  • Mechanism of NLRP3 inflammasome activation

    Fayyaz S. Sutterwala;Fayyaz S. Sutterwala;Stefanie Haasken;Suzanne L. Cassel

  • Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

    Shankar S. Iyer;Wilco P. Pulskens;Jeffrey J. Sadler;Loes M. Butter

  • Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome

    Fayyaz S. Sutterwala;Lilia A. Mijares;Li Li;Yasunori Ogura

  • Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

    Avlin B. Imaeda;Azuma Watanabe;Muhammad A. Sohail;Shamail Mahmood

  • The Inflammasome: First Line of the Immune Response to Cell Stress

    Yasunori Ogura;Fayyaz S. Sutterwala;Richard A. Flavell

  • Cutting Edge: Caspase-1 Independent IL-1β Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

    Katrin D. Mayer-Barber;Daniel L. Barber;Kevin Shenderov;Sandra D. White

  • Transforming growth factor-beta controls T helper type 1 cell development through regulation of natural killer cell interferon-gamma.

    Yasmina Laouar;Fayyaz S Sutterwala;Leonid Gorelik;Leonid Gorelik;Richard A Flavell;Richard A Flavell

  • Expression of Interleukin-10 in Intestinal Lymphocytes Detected by an Interleukin-10 Reporter Knockin tiger Mouse

    Masahito Kamanaka;Sean T. Kim;Yisong Y. Wan;Fayyaz S. Sutterwala

  • Selective Suppression of Interleukin-12 Induction after Macrophage Receptor Ligation

    Fayyaz S. Sutterwala;Gary J. Noel;Raphael Clynes;David M. Mosser

  • Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis

    Maria Lara-Tejero;Fayyaz S. Sutterwala;Yasunori Ogura;Ethan P. Grant

  • Reversal of Proinflammatory Responses by Ligating the Macrophage Fcγ Receptor Type I

    Fayyaz S. Sutterwala;Gary J. Noel;Padmini Salgame;David M. Mosser

  • Obesity and cancer: inflammation bridges the two

    Ryan Kolb;Fayyaz S Sutterwala;Weizhou Zhang

  • TRPM2 links oxidative stress to NLRP3 inflammasome activation.

    Zhenyu Zhong;Yougang Zhai;Shuang Liang;Yasuo Mori

  • Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

    Marina Tiemi Shio;Stephanie C. Eisenbarth;Myriam Savaria;Adrien F. Vinet

Frequent Co-Authors

Richard A. Flavell
Richard A. Flavell Yale University
Mary E. Wilson
Mary E. Wilson University of California, San Francisco
David K. Meyerholz
David K. Meyerholz University of Iowa
Alan Sher
Alan Sher National Institute of Allergy and Infectious Diseases
William M. Nauseef
William M. Nauseef University of Iowa
John Bertin
John Bertin GlaxoSmithKline (United Kingdom)
Bradley D. Jones
Bradley D. Jones University of Iowa
Jorge E. Galán
Jorge E. Galán Yale University
Eran Elinav
Eran Elinav Weizmann Institute of Science

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