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Mohamed Lamkanfi

Mohamed Lamkanfi

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
89
Citations
37268
World Ranking
2517
National Ranking
38

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Mohamed Lamkanfi is affiliated with Ghent University in Belgium. Their research spans multiple fields including Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology, and Medicine, with a particular focus on Molecular Biology, Immunology, Infectious Diseases, Public Health, and Hematology.

The main topics in Mohamed Lamkanfi's work include:

  • Inflammasome and immune disorders
  • Immune Response and Inflammation
  • Heme Oxygenase-1 and Carbon Monoxide
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Interferon and immune responses
  • Immune cells in cancer
  • Streptococcal Infections and Treatments

Their recent papers include:

  • Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets, 2023, Nature Reviews Drug Discovery
  • IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D, 2020, Cancer Immunology Research
  • An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages, 2020, Cell Reports
  • Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities, 2020, Nature Immunology
  • Escherichia coli Rho GTPase-activating toxin CNF1 mediates NLRP3 inflammasome activation via p21-activated kinases-1/2 during bacteraemia in mice, 2021, Nature Microbiology

Mohamed Lamkanfi frequently collaborates with the following researchers:

  • Lieselotte Vande Walle
  • Geert Loo
  • Andy Wullaert
  • Nina Van Opdenbosch
  • Hanne Van Gorp

Their work has been published multiple times in several prominent venues including:

  • Frontiers in Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Reviews Drug Discovery
  • Nature Immunology
  • Annals of the Rheumatic Diseases

Best Publications

  • Non-canonical inflammasome activation targets caspase-11

    Nobuhiko Kayagaki;Søren Warming;Mohamed Lamkanfi;Lieselotte Vande Walle

  • Mechanisms and Functions of Inflammasomes

    Mohamed Lamkanfi;Vishva M. Dixit

  • Intracellular NOD-like Receptors in Host Defense and Disease

    Thirumala Devi Kanneganti;Mohamed Lamkanfi;Gabriel Núñez

  • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

    Md. Hasan Zaki;Kelli L. Boyd;Peter Vogel;Michael B. Kastan

  • Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

    Melanie Fritsch;Saskia D. Günther;Robin Schwarzer;Marie-Christine Albert

  • Inflammasomes and their roles in health and disease.

    Mohamed Lamkanfi;Vishva M. Dixit

  • Caspases in Cell Death, Inflammation, and Disease

    Nina Van Opdenbosch;Mohamed Lamkanfi;Mohamed Lamkanfi

  • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

    Mohamed Lamkanfi;James L. Mueller;Alberto C. Vitari;Shahram Misaghi

  • The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

    Paul G. Thomas;Pradyot Dash;Jerry R. Aldridge;Ali H. Ellebedy

  • Caspases in cell survival, proliferation and differentiation

    M Lamkanfi;N Festjens;W Declercq;T Vanden Berghe

  • Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella

    Petr Broz;Kim Newton;Mohamed Lamkanfi;Sanjeev Mariathasan

  • Inflammasomes in neuroinflammatory and neurodegenerative diseases.

    Sofie Voet;Sahana Srinivasan;Mohamed Lamkanfi;Mohamed Lamkanfi;Geert van Loo

  • Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.

    Thirumala Devi Kanneganti;Mohamed Lamkanfi;Yun Gi Kim;Grace Chen

  • Increased Inflammatory Gene Expression in ABC Transporter-Deficient Macrophages: Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions

    Laurent Yvan-Charvet;Carrie Welch;Tamara A. Pagler;Mollie Ranalletta

  • FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

    Prajwal Gurung;Paras K. Anand;R. K. Subbarao Malireddi;Lieselotte Vande Walle;Lieselotte Vande Walle

  • Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

    Mohamed Lamkanfi;Mohamed Lamkanfi;Mohamed Lamkanfi;Anasuya Sarkar;Lieselotte Vande Walle;Lieselotte Vande Walle;Alberto C. Vitari

  • Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

    Lieselotte Vande Walle;Nina Van Opdenbosch;Peggy Jacques;Amelie Fossoul

  • Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

    Mohamed Lamkanfi;Wim Declercq;Michaël Kalai;Xavier Saelens

  • Manipulation of Host Cell Death Pathways during Microbial Infections

    Mohamed Lamkanfi;Vishva M. Dixit

  • Emerging inflammasome effector mechanisms.

    Mohamed Lamkanfi

Frequent Co-Authors

Thirumala-Devi Kanneganti
Thirumala-Devi Kanneganti St. Jude Children's Research Hospital
Peter Vandenabeele
Peter Vandenabeele Ghent University
Peter Vogel
Peter Vogel St. Jude Children's Research Hospital
Douglas R. Green
Douglas R. Green St. Jude Children's Research Hospital
Gabriel Núñez
Gabriel Núñez University of Michigan–Ann Arbor
Wim Declercq
Wim Declercq Ghent University
Xavier Saelens
Xavier Saelens Ghent University
Si Ming Man
Si Ming Man Australian National University
Tom Vanden Berghe
Tom Vanden Berghe University of Antwerp

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