Xavier Saelens

Overview

Best Publications

• Toxic proteins released from mitochondria in cell death

  Xavier Saelens;Nele Festjens;Lieselotte Vande Walle;Maria van Gurp

  1419
  Citations

• A universal influenza A vaccine based on the extracellular domain of the M2 protein.

  Sabine Neirynck;Tom Deroo;Xavier Saelens;Peter Vanlandschoot

  1191
  Citations

• The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet.

  G van Loo;X Saelens;M van Gurp;M MacFarlane

  891
  Citations

• Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.

  Daniel Wrapp;Dorien De Vlieger;Kizzmekia S. Corbett;Gretel M. Torres

  661
  Citations

• Mitochondrial intermembrane proteins in cell death.

  Maria van Gurp;Nele Festjens;Geert van Loo;Xavier Saelens

  545
  Citations

• Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

  Mohamed Lamkanfi;Wim Declercq;Michaël Kalai;Xavier Saelens

  510
  Citations

• Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

  Karim El Bakkouri;Francis Descamps;Marina De Filette;Anouk Smet

  450
  Citations

• Correction: Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state

  Iebe Rossey;Morgan S. A. Gilman;Stephanie C. Kabeche;Koen Sedeyn

  400
  Citations

• Mx Proteins: Antiviral Gatekeepers That Restrain the Uninvited

  Judith Verhelst;Paco Hulpiau;Xavier Saelens

  370
  Citations

• M2e-based universal influenza A vaccine.

  Lei Deng;Ki Joon Cho;Walter Fiers;Xavier Saelens

  316
  Citations

• Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

  Michael Schotsaert;Marina De Filette;Walter Fiers;Xavier Saelens

  301
  Citations

• Interferon-Inducible Protein Mx1 Inhibits Influenza Virus by Interfering with Functional Viral Ribonucleoprotein Complex Assembly

  Judith Verhelst;Eef Parthoens;Bert Schepens;Walter Fiers

  280
  Citations

• Phagocytosis of Necrotic Cells by Macrophages Is Phosphatidylserine Dependent and Does Not Induce Inflammatory Cytokine Production

  Greet Brouckaert;Michaël Kalai;Dmitri V. Krysko;Xavier Saelens

  278
  Citations

• STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters.

  Robbert Boudewijns;Robbert Boudewijns;Hendrik Jan Thibaut;Hendrik Jan Thibaut;Suzanne J. F. Kaptein;Suzanne J. F. Kaptein;Rong Li

  269
  Citations

• Translation Inhibition in Apoptosis CASPASE-DEPENDENT PKR ACTIVATION AND eIF2-α PHOSPHORYLATION

  Xavier Saelens;Michael Kalai;Peter Vandenabeele

  254
  Citations

• Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA.

  M Kalai;G Van Loo;T Vanden Berghe;A Meeus

  227
  Citations

• Llama-derived single domain antibodies to build multivalent, superpotent and broadened neutralizing anti-viral molecules.

  Anna Hultberg;Nigel J. Temperton;Nigel J. Temperton;Valérie Rosseels;Mireille Koenders

  215
  Citations

• Caspase-1 Activates Nuclear Factor of the κ-Enhancer in B Cells Independently of Its Enzymatic Activity

  Mohamed Lamkanfi;Michael Kalai;Xavier Saelens;Wim Declercq

  206
  Citations

• Improved design and intranasal delivery of an M2e-based human influenza A vaccine.

  Marina De Filette;Walter Fiers;Wouter Martens;Ashley Birkett

  197
  Citations

• Differential Signaling to Apoptotic and Necrotic Cell Death by Fas-associated Death Domain Protein FADD

  Tom Vanden Berghe;Geert van Loo;Xavier Saelens;Maria van Gurp

  186
  Citations

• The universal influenza vaccine M2e-HBc administered intranasally in combination with the adjuvant CTA1-DD provides complete protection.

  Marina De Filette;Anna Ramne;Ashley Birkett;Nils Lycke

  182
  Citations

• An Influenza A Vaccine Based on Tetrameric Ectodomain of Matrix Protein 2

  Marina De Filette;Marina De Filette;Wouter Martens;Wouter Martens;Kenny Roose;Kenny Roose;Tom Deroo;Tom Deroo

  179
  Citations

• CTA1-M2e-DD: a novel mucosal adjuvant targeted influenza vaccine.

  Dubravka Grdic Eliasson;Karim El Bakkouri;Karin Schön;Anna Ramne

  175
  Citations