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Wim Declercq

Wim Declercq

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
78
Citations
25670
World Ranking
4492
National Ranking
73

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Wim Declercq is affiliated with Ghent University in Belgium, where their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Their work spans multiple subfields including Immunology, Molecular Biology, Cancer Research, Physiology, and Cell Biology.

The scientist's research topics include interferon and immune responses, cell death mechanisms and regulation, RNA regulation and disease, inflammasome and immune disorders, immunotherapy and immune responses, NF-κB signaling pathways, and T-cell and B-cell immunology.

Frequent publication venues for Wim Declercq include the Journal of Investigative Dermatology, Cellular and Molecular Life Sciences, Nature, Trends in Pharmacological Sciences, and The Journal of Experimental Medicine.

They have coauthored multiple papers with several researchers, including Peter Vandenabeele, Jonathan Maelfait, Giel Tanghe, Michaël Devos, and Paco Hulpiau.

Recent notable papers include:

  • ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation, 2022, Nature
  • Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs, 2020, Trends in Pharmacological Sciences
  • Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation, 2020, The Journal of Experimental Medicine
  • Correction: A20 protects cells from TNF-induced apoptosis through linear ubiquitin-dependent and -independent mechanisms, 2020, Cell Death and Disease
  • Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection, 2020, The Journal of Immunology

Best Publications

  • More than one way to die: apoptosis, necrosis and reactive oxygen damage

    Walter Fiers;Rudi Beyaert;Wim Declercq;Peter Vandenabeele

  • Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor

    Dominique Vercammen;Rudi Beyaert;Geertrui Denecker;Vera Goossens

  • Two tumour necrosis factor receptors: structure and function.

    Peter Vandenabeele;Wim Declercq;Rudi Beyaert;Walter Fiers

  • MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates

    Yves Dondelinger;Wim Declercq;Sylvie Montessuit;Ria Roelandt

  • Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

    E Wirawan;L Vande Walle;K Kersse;S Cornelis;S Cornelis

  • Caspases in cell survival, proliferation and differentiation

    M Lamkanfi;N Festjens;W Declercq;T Vanden Berghe

  • Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features

    T Vanden Berghe;N Vanlangenakker;E Parthoens;W Deckers

  • Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways

    Dominique Vercammen;Greet Brouckaert;Geertrui Denecker;Marc Van de Craen

  • RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome

    Linde Duprez;Nozomi Takahashi;Nozomi Takahashi;Filip Van Hauwermeiren;Filip Van Hauwermeiren;Benjamin Vandendriessche;Benjamin Vandendriessche

  • RIP Kinases at the Crossroads of Cell Death and Survival

    Wim Declercq;Tom Vanden Berghe;Peter Vandenabeele

  • The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

    Peter Vandenabeele;Wim Declercq;Franky Van Herreweghe;Tom Vanden Berghe

  • Cell death by cornification.

    Leopold Eckhart;Saskia Lippens;Erwin Tschachler;Wim Declercq

  • The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity.

    G van Loo;M van Gurp;B Depuydt;S M Srinivasula

  • Alice in caspase land. A phylogenetic analysis of caspases from worm to man.

    Mohamed Lamkanfi;Wim Declercq;Michaël Kalai;Xavier Saelens

  • Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models.

    N Takahashi;L Duprez;S Grootjans;A Cauwels

  • Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation

    G van Loo;P Schotte;M van Gurp;H Demol

  • Non-specific effects of methyl ketone peptide inhibitors of caspases

    Peter Schotte;Wim Declercq;Sofie Van Huffel;Peter Vandenabeele

  • Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.

    Tania Løve Aaes;Agnieszka Kaczmarek;Tinneke Delvaeye;Bram De Craene

  • Apoptotic and necrotic cell death induced by death domain receptors.

    Geertrui Denecker;D Vercammen;Wim Declercq;Peter Vandenabeele

  • Caspase-14 protects against epidermal UVB photodamage and water loss.

    Geertrui Denecker;Esther Hoste;Barbara Gilbert;Tino Hochepied

Frequent Co-Authors

Peter Vandenabeele
Peter Vandenabeele Ghent University
Tom Vanden Berghe
Tom Vanden Berghe University of Antwerp
Walter Fiers
Walter Fiers Ghent University
Geert van Loo
Geert van Loo Ghent University
Kris Gevaert
Kris Gevaert Ghent University
Xavier Saelens
Xavier Saelens Ghent University
Erwin Tschachler
Erwin Tschachler Medical University of Vienna
Joël Vandekerckhove
Joël Vandekerckhove Ghent University
Mohamed Lamkanfi
Mohamed Lamkanfi Ghent University

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